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AR097479A1 - GLYCEROL AND ACETIC ACID CONVERTER CELLS WITH AN IMPROVED GLYCEROL TRANSPORT - Google Patents

GLYCEROL AND ACETIC ACID CONVERTER CELLS WITH AN IMPROVED GLYCEROL TRANSPORT

Info

Publication number
AR097479A1
AR097479A1 ARP140103221A ARP140103221A AR097479A1 AR 097479 A1 AR097479 A1 AR 097479A1 AR P140103221 A ARP140103221 A AR P140103221A AR P140103221 A ARP140103221 A AR P140103221A AR 097479 A1 AR097479 A1 AR 097479A1
Authority
AR
Argentina
Prior art keywords
glycerol
seq
sequences encoding
acetic acid
improved
Prior art date
Application number
ARP140103221A
Other languages
Spanish (es)
Inventor
Klaassen Paul
Willem Antonius Hartman Wouter
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of AR097479A1 publication Critical patent/AR097479A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
    • C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Una célula que fue modificada genéticamente que comprende: a) una o más secuencias de nucleótidos que codifican una glicerol deshidrogenasa (E.C. 1.1.1.6); b) una o más secuencias de nucleótidos que codifican una dihidroxiacetona quinasa (E.C. 2.7.1.28 o E.C. 2.7.1.29); y c) una o más secuencias de nucleótidos que codifican un transportador de glicerol. Reivindicación 3: Una célula de acuerdo con la reivindicación 1 ó 2, caracterizada porque la célula comprende una o más secuencias de ácidos nucleicos que codifican un transportador de glicerol heterólogo representado por la SEQ ID Nº 31 o un homólogo funcional de la SEQ ID Nº 31 que tiene una identidad de secuencia de por lo menos un 60% con la SEQ ID Nº 31. Reivindicación 4: Una célula de acuerdo con la reivindicación 1 ó 2, caracterizada porque la célula comprende una o más secuencias de ácidos nucleicos que codifican un transportador de glicerol heterélogo representado por la SEQ ID Nº 29 o un homólogo funcional de la SEQ ID Nº 29 que tiene una identidad de secuencia de por lo menos un 50% con la SEQ ID Nº 29.A cell that was genetically modified comprising: a) one or more nucleotide sequences encoding a glycerol dehydrogenase (E.C. 1.1.1.6); b) one or more nucleotide sequences encoding a dihydroxyacetone kinase (E.C. 2.7.1.28 or E.C. 2.7.1.29); and c) one or more nucleotide sequences encoding a glycerol transporter. Claim 3: A cell according to claim 1 or 2, characterized in that the cell comprises one or more nucleic acid sequences encoding a heterologous glycerol transporter represented by SEQ ID No. 31 or a functional homologue of SEQ ID No. 31 having a sequence identity of at least 60% with SEQ ID No. 31. Claim 4: A cell according to claim 1 or 2, characterized in that the cell comprises one or more nucleic acid sequences encoding a transporter of heterologous glycerol represented by SEQ ID No. 29 or a functional counterpart of SEQ ID No. 29 that has a sequence identity of at least 50% with SEQ ID No. 29.

ARP140103221A 2013-08-29 2014-08-27 GLYCEROL AND ACETIC ACID CONVERTER CELLS WITH AN IMPROVED GLYCEROL TRANSPORT AR097479A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13182225 2013-08-29

Publications (1)

Publication Number Publication Date
AR097479A1 true AR097479A1 (en) 2016-03-16

Family

ID=49036505

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140103221A AR097479A1 (en) 2013-08-29 2014-08-27 GLYCEROL AND ACETIC ACID CONVERTER CELLS WITH AN IMPROVED GLYCEROL TRANSPORT

Country Status (2)

Country Link
AR (1) AR097479A1 (en)
WO (1) WO2015028583A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112015003261B4 (en) * 2014-07-14 2025-04-10 Constructor University Bremen Ggmbh Genetically modified yeast with improved glycerol catabolism
HUE053810T2 (en) * 2014-12-19 2021-07-28 Dsm Ip Assets Bv Fermentation process with improved glycerol and acetic acid conversion
DK3298133T3 (en) 2015-05-22 2019-12-09 Dsm Ip Assets Bv ACETATE CONSUMPING GERCELLE
ES2767728T3 (en) 2015-10-06 2020-06-18 Dsm Ip Assets Bv Eukaryotic cell with high production of fermentation product
ES2924108T3 (en) 2016-12-20 2022-10-04 Dsm Ip Assets Bv Improved yeast strains for ethanol production
CN110088275A (en) * 2016-12-23 2019-08-02 帝斯曼知识产权资产管理有限公司 The ethyl alcohol of improved no glycerol produces
US20200024619A1 (en) * 2017-03-21 2020-01-23 Dsm Ip Assets B.V. Improved glycerol free ethanol production
BR112019019701A2 (en) * 2017-03-24 2020-07-14 Danisco Us Inc. reduction of acetate and glycerol in modified yeast that has an exogenous ethanol production path
CN111133111A (en) * 2017-09-26 2020-05-08 帝斯曼知识产权资产管理有限公司 acetic acid consuming strains
EP3700920A1 (en) * 2017-10-24 2020-09-02 Danisco US Inc. Yeast with improved alcohol production
BR112022007870A2 (en) 2019-11-08 2022-07-12 Dsm Ip Assets Bv PROCESS TO PRODUCE ETHANOL
WO2022261003A1 (en) 2021-06-07 2022-12-15 Novozymes A/S Engineered microorganism for improved ethanol fermentation
US20250333768A1 (en) 2021-07-12 2025-10-30 Danisco Us Inc. Recombinant yeast cell
CN117916381A (en) 2021-07-12 2024-04-19 丹尼斯科美国公司 Recombinant yeast cells
WO2023285280A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
WO2023285294A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
CN117940570A (en) 2021-07-12 2024-04-26 丹尼斯科美国公司 Recombinant yeast cells
EP4370690A1 (en) 2021-07-12 2024-05-22 Danisco Us Inc Recombinant yeast cell
EP4426824A1 (en) 2021-11-04 2024-09-11 Danisco US Inc. Recombinant yeast cell

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008006037A2 (en) * 2006-07-06 2008-01-10 Integrated Genomics, Inc. Compositions and methods for enhancing glycerol utilization
WO2010015122A1 (en) * 2008-08-06 2010-02-11 Tianjin University Yeast strains and methods for making and using such yeast strains
WO2010019882A1 (en) * 2008-08-15 2010-02-18 Edeniq, Inc. Genetically-engineered yeast and methods of making and using
US20110250664A1 (en) * 2010-04-08 2011-10-13 Tianjin University Yeast having improved ethanol yield
WO2011132890A2 (en) * 2010-04-19 2011-10-27 고려대학교 산학협력단 Transformant for enhancing bioethanol production, and method for producing ethanol by using said strain
WO2011149353A1 (en) * 2010-05-27 2011-12-01 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
WO2012067510A1 (en) * 2010-11-18 2012-05-24 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from glycerol
WO2013081456A2 (en) * 2011-11-30 2013-06-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol

Also Published As

Publication number Publication date
WO2015028583A3 (en) 2015-04-23
WO2015028583A2 (en) 2015-03-05

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