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AR097404A1 - MONOVALENT BIESPECFIC DIACUMS THAT ARE ABLE TO JOIN GPA33 AND CD3, AND USES OF THE SAME - Google Patents

MONOVALENT BIESPECFIC DIACUMS THAT ARE ABLE TO JOIN GPA33 AND CD3, AND USES OF THE SAME

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Publication number
AR097404A1
AR097404A1 ARP140103130A ARP140103130A AR097404A1 AR 097404 A1 AR097404 A1 AR 097404A1 AR P140103130 A ARP140103130 A AR P140103130A AR P140103130 A ARP140103130 A AR P140103130A AR 097404 A1 AR097404 A1 AR 097404A1
Authority
AR
Argentina
Prior art keywords
gpa33
diabodies
bispecific monovalent
monovalent
epitope
Prior art date
Application number
ARP140103130A
Other languages
Spanish (es)
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of AR097404A1 publication Critical patent/AR097404A1/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente se dirige a diacuerpos monovalentes biespecíficos que comprenden dos cadenas de polipéptidos y los cuales poseen al menos un sitio que une de manera especifica a un epítopo de CD3 y un sitio que une de manera específica a un epítopo de gpA33 (es decir, un diacuerpo monovalente biespecífico de gpA33 x CD3). La presente también se dirige a diacuerpos monovalentes biespecíficos que comprenden un Dominio Fc de inmunoglobulina (diacuerpos Fc monovalentes biespecíficos) y se componen de tres cadenas de polipéptidos y las cuales poseen al menos un sitio que une de manera especifica a un epítopo de gpA33 y un sitio que une de manera especifica a un epítopo de CD3 (es decir, un diacuerpo Fc monovalente biespecífico de gpA33 x CD3). Los diacuerpos monovalentes biespecíficos y diacuerpos Fc monovalentes biespecíficos de la presente son capaces de unión simultánea a gpA33 y CD3. La solicitud se dirige a composiciones farmacéuticas que contienen tales diacuerpos monovalentes biespecíficos o tales diacuerpos Fc monovalentes biespecíficos. Además, se dirige a métodos para el uso de tales diacuerpos en el tratamiento de cáncer y otras enfermedades y padecimientos.This is directed to bispecific monovalent diabodies that comprise two polypeptide chains and which have at least one site that specifically binds a CD3 epitope and a site that specifically binds to a gpA33 epitope (i.e., a bispecific monovalent diabody of gpA33 x CD3). This is also directed to bispecific monovalent diabodies that comprise an immunoglobulin Fc Domain (bispecific monovalent Fc diabodies) and are composed of three chains of polypeptides and which possess at least one site that specifically binds an epitope of gpA33 and a site that specifically binds a CD3 epitope (i.e., a bispecific monovalent Fc diabody of gpA33 x CD3). The bispecific monovalent diabodies and bispecific monovalent monobial diabodies of the present are capable of simultaneous binding to gpA33 and CD3. The request is directed to pharmaceutical compositions containing such bispecific monovalent diabodies or such bispecific monovalent Fc diabodies. In addition, it addresses methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.

ARP140103130A 2013-08-23 2014-08-20 MONOVALENT BIESPECFIC DIACUMS THAT ARE ABLE TO JOIN GPA33 AND CD3, AND USES OF THE SAME AR097404A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361869528P 2013-08-23 2013-08-23

Publications (1)

Publication Number Publication Date
AR097404A1 true AR097404A1 (en) 2016-03-09

Family

ID=56131694

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140103130A AR097404A1 (en) 2013-08-23 2014-08-20 MONOVALENT BIESPECFIC DIACUMS THAT ARE ABLE TO JOIN GPA33 AND CD3, AND USES OF THE SAME

Country Status (1)

Country Link
AR (1) AR097404A1 (en)

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