AR097260A1 - FC BI-SPECIFIC MONOVALENT DIACUMS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF THE SAME - Google Patents
FC BI-SPECIFIC MONOVALENT DIACUMS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF THE SAMEInfo
- Publication number
- AR097260A1 AR097260A1 ARP140102956A ARP140102956A AR097260A1 AR 097260 A1 AR097260 A1 AR 097260A1 AR P140102956 A ARP140102956 A AR P140102956A AR P140102956 A ARP140102956 A AR P140102956A AR 097260 A1 AR097260 A1 AR 097260A1
- Authority
- AR
- Argentina
- Prior art keywords
- specific
- cd32b
- cd79b
- monovalent
- diabodies
- Prior art date
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente solicitud está dirigida a diacuerpos monovalentes bi-específicos que comprenden un dominio Fc de inmunoglobulina (diacuerpos de Fc monovalentes bi-específicos) y están compuestos de tres cadenas de polipéptido y que poseen por lo menos un sitio de unión especifico para un epítopo de CD32B y un sitio de unión específico para un epitopo de CD79b (es decir, un diacuerpo de Fc monovalente bi-específico CD32B x CD79b). Los diacuerpos de Fc monovalentes bi-específicos de la presente solicitud son capaces de la unión simultánea a CD32B y CD79b. La solicitud está dirigida a dichas composiciones, a composiciones farmacéuticas que contienen dichos diacuerpos de Fc monovalentes bi-específicos y a métodos para su uso en el tratamiento de enfermedades o condiciones inflamatorias, y en particular, lupus eritematoso sistémico (SLE) y enfermedad de injerto contra huésped. Reivindicación 3: El diacuerpo de Fc monovalente bi-específico de conformidad con la reivindicación 1, en donde dicho sub-dominio (1B) de dicha primera cadena de polipéptido tiene la secuencia de aminoácido de SEC ID Nº 9, y dicho sub-dominio (1B) de dicha tercera cadena de polipéptido tiene la secuencia de aminoácido de SEC ID Nº 10.The present application is directed to bi-specific monovalent diabodies comprising an immunoglobulin Fc domain (bi-specific monovalent Fc diabodies) and are composed of three polypeptide chains and having at least one specific binding site for an epitope of CD32B and a specific binding site for an epitope of CD79b (ie, a monovalent bi-specific Fc diabody CD32B x CD79b). The bi-specific monovalent Fc diabodies of the present application are capable of simultaneous binding to CD32B and CD79b. The request is directed to said compositions, to pharmaceutical compositions containing said bi-specific monovalent Fc diabodies and to methods for use in the treatment of inflammatory diseases or conditions, and in particular, systemic lupus erythematosus (SLE) and graft disease against Guest. Claim 3: The bi-specific monovalent Fc diabody according to claim 1, wherein said sub-domain (1B) of said first polypeptide chain has the amino acid sequence of SEQ ID NO: 9, and said sub-domain ( 1B) of said third polypeptide chain has the amino acid sequence of SEQ ID NO: 10.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361864217P | 2013-08-09 | 2013-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR097260A1 true AR097260A1 (en) | 2016-03-02 |
Family
ID=56131708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140102956A AR097260A1 (en) | 2013-08-09 | 2014-08-06 | FC BI-SPECIFIC MONOVALENT DIACUMS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF THE SAME |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR097260A1 (en) |
-
2014
- 2014-08-06 AR ARP140102956A patent/AR097260A1/en active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |