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AR095598A1 - Composiciones y métodos para construcciones quiméricas del virus del dengue en vacunas - Google Patents

Composiciones y métodos para construcciones quiméricas del virus del dengue en vacunas

Info

Publication number
AR095598A1
AR095598A1 ARP140101223A ARP140101223A AR095598A1 AR 095598 A1 AR095598 A1 AR 095598A1 AR P140101223 A ARP140101223 A AR P140101223A AR P140101223 A ARP140101223 A AR P140101223A AR 095598 A1 AR095598 A1 AR 095598A1
Authority
AR
Argentina
Prior art keywords
dengue
virus
constructs
den
compositions
Prior art date
Application number
ARP140101223A
Other languages
English (en)
Inventor
T Stinchcomb Dan
Y Huang Claire
M Kinney Richard
Al Livengood Jill
Original Assignee
The Government Of The Us Secretary Dept Of Health And Human Services
Inviragen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The Us Secretary Dept Of Health And Human Services, Inviragen Inc filed Critical The Government Of The Us Secretary Dept Of Health And Human Services
Publication of AR095598A1 publication Critical patent/AR095598A1/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/18—Togaviridae; Flaviviridae
    • C07K14/1816—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus), border disease virus
    • C07K14/1825—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
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    • C12N15/86—Viral vectors
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    • C12N15/8613—Chimaeric vector systems comprising heterologous sequences for production of another viral vector
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/24011—Flaviviridae
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24141—Use of virus, viral particle or viral elements as a vector
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
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    • C12N2770/24161—Methods of inactivation or attenuation
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    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract

Las modalidades en el presente documento informan sobre composiciones, aplicaciones y fabricación de construcciones de virus del dengue y de virus vivos atenuados del dengue. Algunas modalidades se refieren a una composición que incluye, pero no se limita a, una composición tetravalente del virus del dengue. En ciertas modalidades, las composiciones pueden incluir construcciones de uno o más serotipos del virus del dengue, tales como construcciones del virus del dengue-1 (DEN-1), virus del dengue-2 (DEN-2), virus del dengue-3 (DEN-3) o virus del dengue-4 (DEN-4). En otras modalidades, las construcciones divulgadas en el presente documento pueden combinarse en una composición para generar una vacuna contra una o más construcciones del virus del dengue que pueden o no ser pasadas posteriormente en células de mamíferos. Reivindicación 1: Una quimera del ácido nucleico que comprende una primera secuencia de nucleótidos que codifican las proteínas no estructurales de una cepa PDK-S3 modificada del virus vivo, atenuado del dengue-2 y una segunda secuencia de nucleótidos que codifican al menos una proteína estructural del dengue-1, en donde el virus vivo, atenuado del dengue-2 también comprende al menos una mutación adicional que incluye una mutación en la posición 3823 del ácido nucleico, en donde la posición 116 del aminoácido del gen de NSZA es una leucina en lugar de isoleucina.
ARP140101223A 2013-03-15 2014-03-17 Composiciones y métodos para construcciones quiméricas del virus del dengue en vacunas AR095598A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361800204P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
AR095598A1 true AR095598A1 (es) 2015-10-28

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ID=50678274

Family Applications (4)

Application Number Title Priority Date Filing Date
ARP140101223A AR095598A1 (es) 2013-03-15 2014-03-17 Composiciones y métodos para construcciones quiméricas del virus del dengue en vacunas
ARP210102772A AR123702A2 (es) 2013-03-15 2021-10-06 Moléculas de polinucleótido y de polipéptido, virus de dengue, composiciones, vector, célula, kit y métodos relacionados
ARP240100498A AR132009A2 (es) 2013-03-15 2024-02-28 Moléculas de polinucleótido y de polipéptido, virus de dengue, composiciones, vector y célula
ARP240101841A AR133264A2 (es) 2013-03-15 2024-07-16 Moléculas de polinucleótido y de polipéptido, virus de dengue, composiciones, vector y célula

Family Applications After (3)

Application Number Title Priority Date Filing Date
ARP210102772A AR123702A2 (es) 2013-03-15 2021-10-06 Moléculas de polinucleótido y de polipéptido, virus de dengue, composiciones, vector, célula, kit y métodos relacionados
ARP240100498A AR132009A2 (es) 2013-03-15 2024-02-28 Moléculas de polinucleótido y de polipéptido, virus de dengue, composiciones, vector y célula
ARP240101841A AR133264A2 (es) 2013-03-15 2024-07-16 Moléculas de polinucleótido y de polipéptido, virus de dengue, composiciones, vector y célula

Country Status (32)

Country Link
US (6) US9783579B2 (es)
EP (5) EP3539565B1 (es)
JP (2) JP6818548B2 (es)
KR (4) KR20250033325A (es)
CN (5) CN113637086B (es)
AR (4) AR095598A1 (es)
AU (2) AU2014235476B2 (es)
CA (3) CA3177574A1 (es)
CR (1) CR20150569A (es)
DK (1) DK4129330T5 (es)
DO (1) DOP2015000232A (es)
EC (1) ECSP23013715A (es)
ES (2) ES2933970T3 (es)
FI (2) FI3539565T3 (es)
FR (1) FR22C1064I2 (es)
HR (1) HRP20231581T1 (es)
HU (2) HUE061507T2 (es)
LT (2) LT4129330T (es)
MX (5) MX374519B (es)
MY (1) MY187796A (es)
NL (1) NL301223I2 (es)
NO (1) NO2023026I1 (es)
NZ (1) NZ630869A (es)
PE (2) PE20211814A1 (es)
PH (1) PH12015502120B1 (es)
PL (1) PL3539565T3 (es)
PT (1) PT3539565T (es)
SG (3) SG10201913435TA (es)
SI (1) SI4129330T1 (es)
TW (3) TWI733646B (es)
UY (1) UY35489A (es)
WO (1) WO2014150939A2 (es)

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US10004795B2 (en) * 2015-09-08 2018-06-26 Fundacao Butantan Process for preparing an attenuated tetravalent dengue vaccine
BR112018010690A8 (pt) * 2015-11-27 2019-02-26 The Chemo Sero Therapeutic Res Institute vírus vivo tendo um banco de cepas atenuadas do vírus da dengue, e uma vacina da dengue contendo as mesmas como antígenos
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AU2019335006B2 (en) 2018-09-05 2024-07-04 Takeda Vaccines, Inc. Dengue vaccine unit dose and administration thereof
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WO2025122855A1 (en) 2023-12-08 2025-06-12 Takeda Vaccines, Inc. A method for determining the concentration of residual vero cell genomic dna in a sample containing virus obtained from production in vero cells

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