AR094959A1 - Compuestos de imidazo piridina - Google Patents
Compuestos de imidazo piridinaInfo
- Publication number
- AR094959A1 AR094959A1 ARP140100674A ARP140100674A AR094959A1 AR 094959 A1 AR094959 A1 AR 094959A1 AR P140100674 A ARP140100674 A AR P140100674A AR P140100674 A ARP140100674 A AR P140100674A AR 094959 A1 AR094959 A1 AR 094959A1
- Authority
- AR
- Argentina
- Prior art keywords
- piridine
- compounds
- imidazo compounds
- imidazo
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 abstract 1
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
Abstract
Un compuesto o una sal del mismo farmacéuticamente aceptable. Los compuestos son inhibidores de autotaxina. Reivindicación 1: Un compuesto de la fórmula (1) caracterizado porque X es un enlace o CH₂; Q es CH₂ u O; L se selecciona a partir del grupo que consiste de -OCH₂ y -CH₂O; o una sal del mismo farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361777216P | 2013-03-12 | 2013-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094959A1 true AR094959A1 (es) | 2015-09-09 |
Family
ID=50382634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100674A AR094959A1 (es) | 2013-03-12 | 2014-02-28 | Compuestos de imidazo piridina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9394317B2 (es) |
| EP (1) | EP2970254B1 (es) |
| JP (1) | JP6163248B2 (es) |
| KR (1) | KR20150119081A (es) |
| CN (1) | CN105143218B (es) |
| AR (1) | AR094959A1 (es) |
| AU (1) | AU2014228355B2 (es) |
| BR (1) | BR112015018509A2 (es) |
| CA (1) | CA2900956C (es) |
| EA (1) | EA201591486A1 (es) |
| ES (1) | ES2639125T3 (es) |
| MX (1) | MX2015012629A (es) |
| TW (1) | TW201520219A (es) |
| WO (1) | WO2014143583A1 (es) |
| ZA (1) | ZA201506747B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI499591B (zh) * | 2013-01-11 | 2015-09-11 | Lilly Co Eli | 雙環嘧啶化合物 |
| TW201500356A (zh) * | 2013-04-12 | 2015-01-01 | Lilly Co Eli | 二氫吡啶并嘧啶化合物 |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| CN110526929A (zh) * | 2018-05-24 | 2019-12-03 | 广州市恒诺康医药科技有限公司 | 芳杂环化合物、其药物组合物及其应用 |
| IL284994B2 (en) * | 2019-02-01 | 2024-10-01 | Wuhan Humanwell Innovative Drug Res And Development Center Limited Company | Pyrrolopyrimidine derivative and use thereof |
| WO2021088957A1 (zh) * | 2019-11-07 | 2021-05-14 | 广州市恒诺康医药科技有限公司 | 芳杂环化合物、其药物组合物及其应用 |
| KR20220113731A (ko) * | 2019-12-11 | 2022-08-16 | 스촨 하이스코 파마수티컬 씨오., 엘티디 | 질소-함유 헤테로사이클릭 오토택신 억제제, 및 이를 함유하는 조성물 및 이의 용도 |
| CN113943295B (zh) * | 2020-07-16 | 2025-08-12 | 武汉人福创新药物研发中心有限公司 | 吡咯并嘧啶类化合物及其用途 |
| CN113943296B (zh) * | 2020-07-16 | 2025-07-04 | 武汉人福创新药物研发中心有限公司 | 吡咯并嘧啶衍生物及其应用 |
| TWI894325B (zh) * | 2020-07-28 | 2025-08-21 | 大陸商武漢人福創新藥物研發中心有限公司 | 含氮雜環化合物的鹽及其鹽的固體形式、藥物組合物和用途 |
| TW202214644A (zh) * | 2020-07-28 | 2022-04-16 | 大陸商武漢人福創新藥物研發中心有限公司 | 含氮雜環化合物的固體形式及其藥物組合物和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1071301A (en) * | 1999-11-01 | 2001-05-14 | Eli Lilly And Company | Pharmaceutical compounds |
| US7524852B2 (en) | 2002-06-07 | 2009-04-28 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| US7465739B2 (en) * | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| DE102004020908A1 (de) | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
| ES2327240T3 (es) * | 2004-12-13 | 2009-10-27 | Solvay Pharmaceuticals Gmbh | Nuevos derivados sustituidos de tiofempirimidinona en calidad de inhibidores de 17beta-hidroxiesteroide deshidrogenasa. |
| ES2407852T3 (es) * | 2008-12-01 | 2013-06-14 | Merck Patent Gmbh | Pirido[4,3-d]pirimidinas 2,5-diamino sustituidas como inhibidores de autotaxina frente al cáncer |
| ITRE20090102A1 (it) | 2009-10-22 | 2011-04-23 | Cgm Spa | Stampo, attrezzatura e metodo per la formatura dietro compressione di oggetti di materiale termoplastico |
| US9000025B2 (en) * | 2010-08-20 | 2015-04-07 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| EP2714680B1 (en) * | 2011-05-27 | 2015-11-25 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
-
2014
- 2014-02-27 TW TW103106901A patent/TW201520219A/zh unknown
- 2014-02-28 AR ARP140100674A patent/AR094959A1/es unknown
- 2014-03-04 EA EA201591486A patent/EA201591486A1/ru unknown
- 2014-03-04 CA CA2900956A patent/CA2900956C/en not_active Expired - Fee Related
- 2014-03-04 US US14/761,008 patent/US9394317B2/en not_active Expired - Fee Related
- 2014-03-04 KR KR1020157024610A patent/KR20150119081A/ko not_active Ceased
- 2014-03-04 EP EP14712894.6A patent/EP2970254B1/en active Active
- 2014-03-04 MX MX2015012629A patent/MX2015012629A/es unknown
- 2014-03-04 CN CN201480014186.4A patent/CN105143218B/zh not_active Expired - Fee Related
- 2014-03-04 JP JP2016500601A patent/JP6163248B2/ja not_active Expired - Fee Related
- 2014-03-04 WO PCT/US2014/020297 patent/WO2014143583A1/en not_active Ceased
- 2014-03-04 BR BR112015018509A patent/BR112015018509A2/pt not_active IP Right Cessation
- 2014-03-04 ES ES14712894.6T patent/ES2639125T3/es active Active
- 2014-03-04 AU AU2014228355A patent/AU2014228355B2/en not_active Ceased
-
2015
- 2015-09-11 ZA ZA2015/06747A patent/ZA201506747B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150368273A1 (en) | 2015-12-24 |
| US9394317B2 (en) | 2016-07-19 |
| CA2900956C (en) | 2017-11-28 |
| TW201520219A (zh) | 2015-06-01 |
| WO2014143583A1 (en) | 2014-09-18 |
| EP2970254B1 (en) | 2017-06-21 |
| EP2970254A1 (en) | 2016-01-20 |
| KR20150119081A (ko) | 2015-10-23 |
| ES2639125T3 (es) | 2017-10-25 |
| CN105143218A (zh) | 2015-12-09 |
| MX2015012629A (es) | 2016-07-07 |
| EA201591486A1 (ru) | 2016-01-29 |
| BR112015018509A2 (pt) | 2017-07-18 |
| AU2014228355A1 (en) | 2015-10-01 |
| AU2014228355B2 (en) | 2016-02-25 |
| CN105143218B (zh) | 2016-12-14 |
| JP2016512254A (ja) | 2016-04-25 |
| CA2900956A1 (en) | 2014-09-18 |
| JP6163248B2 (ja) | 2017-07-12 |
| ZA201506747B (en) | 2017-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |