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AR080511A1 - Anticuerpos con union de antigenos dependiente del ph - Google Patents

Anticuerpos con union de antigenos dependiente del ph

Info

Publication number
AR080511A1
AR080511A1 ARP110100789A ARP110100789A AR080511A1 AR 080511 A1 AR080511 A1 AR 080511A1 AR P110100789 A ARP110100789 A AR P110100789A AR P110100789 A ARP110100789 A AR P110100789A AR 080511 A1 AR080511 A1 AR 080511A1
Authority
AR
Argentina
Prior art keywords
antigen
antibodies
antibody
bound
life
Prior art date
Application number
ARP110100789A
Other languages
English (en)
Original Assignee
Rinat Neuroscience Corp
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rinat Neuroscience Corp, Pfizer filed Critical Rinat Neuroscience Corp
Publication of AR080511A1 publication Critical patent/AR080511A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente se refiere a anticuerpos con union dependiente de pH a su antígeno de tal forma que la afinidad de union al antígeno a pH fisiologico (es decir, pH 7,4) es mayor que a pH endosomico (es decir, pH 6,0 o 5,5). En otras palabras, la proporcion de KD o la proporcion de koff a pH 5,5/pH 7,4 o a pH 6,0/pH 7,4 es más de, o varía entre, 2, 3, 4, 8, 10, 16, 20, 30, 40, o 100 o más. Tales anticuerpos dependientes de pH se disocian preferencialmente del antígeno en el endosoma. Esto puede incrementar la semivida del anticuerpo, en comparacion con los anticuerpos con KD equivalentes a pH 7,4 pero con ninguna union dependiente de pH, cuando el antígeno es uno que sufre la eliminacion mediada por antígeno (por ejemplo, ketina subtilisina convertasa proproteína tipo 9 PCSK(9). Los anticuerpos con union dependiente de pH pueden disminuir la semivida de antígeno total cuando el antígeno sufre eliminacion reducida cuando se une a anticuerpo (por ejemplo, IL6). Los anticuerpos con union dependiente de pH también pueden prolongar el decrecimiento en antígeno que no está unido a anticuerpo. Esto puede ser importante cuando se antagoniza un antígeno objetivo típicamente presente a niveles altos (por ejemplo, IgE7, dickkopf1 DKK1, C5) y (esclerotina SOST), tales anticuerpos pucden incrementar la semivida de antígeno cuando el antígeno es un receptor y el receptor tiene eliminacion incrementada cuando se une a anticuerpo (por ejemplo, receptor del factor estimulante de colonias de granulocitos y macrofagos: GMCSF). Reivindicacion 31: Un procedimiento para reducir un nivel de LDL-colesterol en sangre de un sujeto en necesidad del mismo, que comprende administrar al sujeto una cantidad terapéuticamente eficaz del anticuerpo de las reivindicaciones 1-26.
ARP110100789A 2010-03-11 2011-03-11 Anticuerpos con union de antigenos dependiente del ph AR080511A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31310210P 2010-03-11 2010-03-11
US201161447638P 2011-02-28 2011-02-28

Publications (1)

Publication Number Publication Date
AR080511A1 true AR080511A1 (es) 2012-04-11

Family

ID=44483937

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100789A AR080511A1 (es) 2010-03-11 2011-03-11 Anticuerpos con union de antigenos dependiente del ph

Country Status (19)

Country Link
US (3) US9029515B2 (es)
EP (1) EP2545079A2 (es)
JP (1) JP5932670B2 (es)
KR (2) KR20150002894A (es)
CN (2) CN102844332B (es)
AR (1) AR080511A1 (es)
AU (1) AU2011225716A1 (es)
BR (1) BR112012022917A2 (es)
CA (1) CA2792740A1 (es)
CO (1) CO6592103A2 (es)
MX (1) MX2012010481A (es)
NZ (1) NZ602220A (es)
PE (1) PE20130393A1 (es)
PH (1) PH12012501758A1 (es)
RU (1) RU2570729C2 (es)
SA (1) SA111320266B1 (es)
SG (2) SG183867A1 (es)
WO (1) WO2011111007A2 (es)
ZA (1) ZA201207211B (es)

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