[go: up one dir, main page]

AR080172A1 - (r) -4- ((4-((4-(tetrahidrofuran-3-iloxi) benzo (d) isoxazol-3-iloxi)metil)piperidin-1-il)metil) tetrahidro-2h-piran-4-ol, un agonista parcial de receptores 5-ht4 y composiciones farmaceuticas que los comprenden - Google Patents

(r) -4- ((4-((4-(tetrahidrofuran-3-iloxi) benzo (d) isoxazol-3-iloxi)metil)piperidin-1-il)metil) tetrahidro-2h-piran-4-ol, un agonista parcial de receptores 5-ht4 y composiciones farmaceuticas que los comprenden

Info

Publication number
AR080172A1
AR080172A1 ARP110100443A ARP110100443A AR080172A1 AR 080172 A1 AR080172 A1 AR 080172A1 AR P110100443 A ARP110100443 A AR P110100443A AR P110100443 A ARP110100443 A AR P110100443A AR 080172 A1 AR080172 A1 AR 080172A1
Authority
AR
Argentina
Prior art keywords
iloxi
methyl
piran
isoxazol
piperidin
Prior art date
Application number
ARP110100443A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR080172A1 publication Critical patent/AR080172A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describe en el presente documento (R)-4-((4-((4-(tetrahidrofuran-3- iloxi)benzo[d]isoxazol-3-iloxi)metil)piperidin-1 -il)metil)tetrahidro-2H-piran-4-oI y su uso en el tratamiento de trastornos neurodegenerativos. Reivindicacion 2: Un compuesto de formula (I) o una sal farmacéuticamente aceptable del mismo.
ARP110100443A 2010-02-16 2011-02-14 (r) -4- ((4-((4-(tetrahidrofuran-3-iloxi) benzo (d) isoxazol-3-iloxi)metil)piperidin-1-il)metil) tetrahidro-2h-piran-4-ol, un agonista parcial de receptores 5-ht4 y composiciones farmaceuticas que los comprenden AR080172A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30492110P 2010-02-16 2010-02-16

Publications (1)

Publication Number Publication Date
AR080172A1 true AR080172A1 (es) 2012-03-21

Family

ID=43904611

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100443A AR080172A1 (es) 2010-02-16 2011-02-14 (r) -4- ((4-((4-(tetrahidrofuran-3-iloxi) benzo (d) isoxazol-3-iloxi)metil)piperidin-1-il)metil) tetrahidro-2h-piran-4-ol, un agonista parcial de receptores 5-ht4 y composiciones farmaceuticas que los comprenden

Country Status (15)

Country Link
US (1) US20120041026A1 (es)
EP (1) EP2536713A1 (es)
JP (1) JP2013519722A (es)
KR (1) KR20120123089A (es)
CN (1) CN102762554A (es)
AR (1) AR080172A1 (es)
AU (1) AU2011216950A1 (es)
CA (1) CA2788656A1 (es)
IN (1) IN2012DN06631A (es)
MX (1) MX2012008721A (es)
SG (1) SG183111A1 (es)
TW (1) TW201141856A (es)
UY (1) UY33225A (es)
WO (1) WO2011101774A1 (es)
ZA (1) ZA201206469B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9737531B2 (en) * 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
US10583138B2 (en) 2012-07-12 2020-03-10 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
CA2836372C (en) * 2011-05-18 2020-09-22 Raqualia Pharma Inc. Polymorph form of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid
BR112015011392A2 (pt) * 2012-11-21 2017-07-11 Raqualia Pharma Inc formas polimórficas de ácidos, processo de preparação, composição farmacêutica e uso das mesmas
WO2014147636A1 (en) 2013-03-20 2014-09-25 Suven Life Sciences Limited 5-amino-quinoline-8-carboxamide derivatives as 5-ht4 receptor agonists
CA2932428C (en) 2013-12-16 2017-10-24 Suven Life Sciences Limited Indazole compounds as 5-ht4 receptor agonists
RU2679619C2 (ru) * 2014-05-20 2019-02-12 Раквалиа Фарма Инк. Солевое производное бензизоксазола
DK3265459T3 (da) 2015-02-13 2019-07-15 Suven Life Sciences Ltd Amidforbindelser som 5-ht4-receptoragonister
CN117796401A (zh) * 2023-12-25 2024-04-02 江苏万隆化学有限公司 一种含2-羟基-6-氟苯甲酸甲酯中间体抗菌剂的制备工艺

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69210229T2 (de) 1991-02-27 1996-11-14 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Dihydrochinolin NMDA Antagonisten
US5750542A (en) * 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
FI952481L (fi) * 1992-11-23 1995-05-22 Hoechst Roussel Pharma Substituoituja 3-(aminoalkyyliamino)-1,2-bentsisoksatoleja ja niihin liittyviä yhdisteitä
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
TR199800531T1 (xx) 1995-09-29 1998-06-22 Glaxo Wellcome Spa NMDA antagonistleri olarak tetrahidrokinolinler.
IL126003A0 (en) 1996-04-10 1999-04-11 Hoechst Marion Roussel Inc Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitors
ES2165586T3 (es) 1996-04-12 2002-03-16 Aventis Pharma Inc Derivados de isatina como inhibidores de acetilcolinesterasa y analgesicos.
JP2000514060A (ja) 1996-07-01 2000-10-24 シェーリング コーポレイション ムスカリン様アンタゴニスト
HUP9904363A3 (en) 1996-08-15 2000-12-28 Schering Corp Piperidine ether muscarinic antagonists and pharmaceutical compositions containing them
KR20000048715A (ko) 1996-09-30 2000-07-25 게리 디. 스트리트, 스티븐 엘. 네스비트 Ｎｍｄａ (ｎ-메틸-ｄ-아스파르테이트) 길항제
KR100648869B1 (ko) 1998-09-30 2007-02-28 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
WO2002059074A1 (en) 2001-01-26 2002-08-01 Sankyo Company, Limited Benzylamine analogue
EP1436258A4 (en) 2001-03-08 2005-03-23 Univ Emory PH VALVE DEPENDENT NMDA RECEPTOR ANTAGONISTS
US7259157B2 (en) 2001-04-03 2007-08-21 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
SK287726B6 (en) 2001-07-24 2011-07-06 Richter Gedeon Vegyeszet Carboxylic acid amide derivatives, their preparation, pharmaceutical compositions containing them and process for preparing pharmaceutical compositions
PL1648882T3 (pl) 2003-06-04 2008-12-31 Merck & Co Inc 3-Fluoro-piperydyny jako antagoniści NMDA/NR2B
GB0316094D0 (en) 2003-07-09 2003-08-13 Neuropharma Sa Acetylcholinesterase dual inhibitors
AU2005218665A1 (en) * 2004-03-03 2005-09-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
HU227119B1 (en) 2004-07-29 2010-07-28 Richter Gedeon Nyrt Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them
HUP0401522A2 (en) 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
HU226977B1 (en) 2004-07-29 2010-04-28 Richter Gedeon Nyrt Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them
HUP0401523A3 (en) 2004-07-29 2007-05-02 Richter Gedeon Vegyeszet Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
HU227000B1 (en) 2004-07-29 2010-04-28 Richter Gedeon Nyrt Nmda receptor antagonist benzoyl urea derivatives, and pharmaceutical compositions containing them
TW200621677A (en) 2004-09-21 2006-07-01 Astellas Pharma Inc Cyclic amine derivative or salt thereof
MX2007004458A (es) 2004-10-15 2007-08-08 Univ Rio De Janeiro Piperidinic derivatives, pharmaceutic compositions containing the same and preparation processes.
US8816090B2 (en) * 2005-02-25 2014-08-26 Pfizer Inc. Benzisoxazole derivatives
US20090124600A1 (en) 2005-04-19 2009-05-14 Layton Mark E N-Alkyl-Azacycloalkyl NMDA/NR2B Antagonists
WO2007016357A1 (en) 2005-07-29 2007-02-08 Regents Of The University Of Minnesota Amyloid beta receptor and uses thereof
EP2001463B1 (en) 2006-03-20 2013-07-03 Council of Scientific and Industrial Research A pharmaceutical composition useful as acetyl cholinesterase inhibitors
ES2288406B1 (es) 2006-04-20 2008-12-16 Universidad De Barcelona Compuestos inhibidores de acetilcolinesterasa para el tratamiento de la enfermedad de alzheimer.
WO2008074816A1 (en) 2006-12-20 2008-06-26 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-cb1 antagonism and acetylcholinesterase inhibition
US7605265B2 (en) 2007-01-22 2009-10-20 Biotechnology Research Corporation Ltd. Heterodimers and methods of using them
PL2152709T3 (pl) 2007-05-01 2012-07-31 Concert Pharmaceuticals Inc Związki morfinanu
GB2462235B8 (en) 2007-05-11 2013-03-27 Biotechnology Res Corp Ltd Receptor modulators exhibiting neuroprotective andmemory enhancing activities
JP2010532382A (ja) 2007-06-29 2010-10-07 エモリー・ユニバーシテイ 神経保護のためのｎｍｄａ受容体拮抗薬
AP2010005217A0 (en) 2007-09-12 2010-04-30 Virginia Tech Intell Prop Insecticidal carbamates exhibiting species-selective inhibition of acetyl cholinesterase (ACHE)
US8722714B2 (en) 2008-01-16 2014-05-13 The Honk Kong University of Science and Technology Oxazolidine derivatives as NMDA antagonists
EA014100B1 (ru) 2008-02-21 2010-08-30 Общество С Ограниченной Ответственностью "Валексфарм" Производные 2,4-диаминопиридина, фармацевтическая композиция, лекарственное средство на их основе для лечения или предупреждения заболеваний и нарушений, вызванных гиперактивацией nmda-рецепторов и/или в качестве стимуляторов когнитивных функций и способ лечения
CN101440061B (zh) 2008-04-08 2010-12-08 温州医学院 一类具有抑制乙酰胆碱酯酶活性的芳基吡啶酮类衍生物
WO2009129181A1 (en) 2008-04-14 2009-10-22 Concert Pharmaceuticals Inc. Propanediol-dicarbamate derivatives
SG195568A1 (en) 2008-05-09 2013-12-30 Univ Emory Nmda receptor antagonists for the treatment of neuropsychiatric disorders

Also Published As

Publication number Publication date
CN102762554A (zh) 2012-10-31
SG183111A1 (en) 2012-09-27
EP2536713A1 (en) 2012-12-26
KR20120123089A (ko) 2012-11-07
MX2012008721A (es) 2012-08-17
AU2011216950A1 (en) 2012-08-23
JP2013519722A (ja) 2013-05-30
IN2012DN06631A (es) 2015-10-23
TW201141856A (en) 2011-12-01
WO2011101774A1 (en) 2011-08-25
ZA201206469B (en) 2013-05-29
US20120041026A1 (en) 2012-02-16
CA2788656A1 (en) 2011-08-25
UY33225A (es) 2011-09-30

Similar Documents

Publication Publication Date Title
AR080172A1 (es) (r) -4- ((4-((4-(tetrahidrofuran-3-iloxi) benzo (d) isoxazol-3-iloxi)metil)piperidin-1-il)metil) tetrahidro-2h-piran-4-ol, un agonista parcial de receptores 5-ht4 y composiciones farmaceuticas que los comprenden
MX2021013075A (es) Oxisteroles y metodos de uso de los mismos.
EA201200049A1 (ru) 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17
AR111425A2 (es) MODULADORES SELECTIVOS DE RECEPTORES DE ANDRÓGENOS (SARMs) Y COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN
GT200900283A (es) "terapia de combinación con un compuesto actuando como un inhibidor del receptor adp plaquetario".
CL2013003527A1 (es) Compuestos heterociclicos antagonistas de los receptores muscarinicos y agonistas del receptor beta2 adrenergico; su composicion farmaceutica; su combinacion; un dispositivo y su uso en la prevencion y/o el tratamiento de enfermedades bronco-obstructivas o inflamatorias como asma y epoc.
CL2012001911A1 (es) Compuestos derivados de fumarato; composicion farmaceutica que los comprende; y su uso en el tratamiento de una enfermedad inflamatoria o neurodegenerativa.
CR9214A (es) 2-fenilindoles como antagonistas del receptor de la prostaglandina d2
CO6541569A2 (es) Inhibidores de n1-pirazoloespirocetona acetil-coa carboxilasa
CO6480932A2 (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida.
MX381041B (es) Compuesto cíclico tipo cumarina como inhibidor de mek y su uso.
TN2016000017A1 (en) Piperidinyl indole derivatives and their use as complement factor b inhibitors
MX390264B (es) Antagonistas d2, metodos de sintesis y metodos de uso.
PE20160605A1 (es) Formulaciones de inhibidores de la syk
MX2009001660A (es) Compuestos de 2,5-dihidroxibenceno para el tratamiento de psoriasis.
UA112055C2 (uk) Солі 4-[2-[[5-метил-1-(2-нафталініл)-1h-піразол-3-іл]оксі]етил]морфоліну
MA32979B1 (fr) Derives aminoesterifies d'alcaloides et composition medicinale les incluant
DE602006006712D1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
UY37837A (es) Nuevos compuestos heterocíclicos como inhibidores de cdk8/19
UY33530A (es) Composiciones farmacéuticas para el tratamiento de enfermedades respiratorias e inflamatorias
CO2017005806A2 (es) Nuevos derivados de bencimidazol como agentes antihistamínicos
AR071721A1 (es) Derivados de piridil-prolinamida, composiciones farmaceuticas que los contienen y su uso para el tratamiento de ansiedad, depresion y trastornos del sueno.
ATE495159T1 (de) Diaminocyclohexan- und diaminocyclopentanderivate
UY30424A1 (es) Derivados de quinolina, su preparacion, su uso y medicamentos que comprenden los mismos.
ATE412636T1 (de) Piperazinylpyridinderivate als mittel gegen adipositas

Legal Events

Date Code Title Description
FA Abandonment or withdrawal