[go: up one dir, main page]

AR087857A1 - Composiciones de yodo-povidona estable - Google Patents

Composiciones de yodo-povidona estable

Info

Publication number
AR087857A1
AR087857A1 ARP120103368A ARP120103368A AR087857A1 AR 087857 A1 AR087857 A1 AR 087857A1 AR P120103368 A ARP120103368 A AR P120103368A AR P120103368 A ARP120103368 A AR P120103368A AR 087857 A1 AR087857 A1 AR 087857A1
Authority
AR
Argentina
Prior art keywords
pvp
concentration
mixing
period
steroid
Prior art date
Application number
ARP120103368A
Other languages
English (en)
Original Assignee
Foresight Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47883771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR087857(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Foresight Biotherapeutics Inc filed Critical Foresight Biotherapeutics Inc
Publication of AR087857A1 publication Critical patent/AR087857A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/12—Iodine, e.g. iodophors; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones que contienen PVP-l-, así como también métodos para fabricar dichas composiciones, que proporcionan estabilidad confiable para preparaciones de PVP-l, que incluyen preparaciones que comprenden PVP-l y uno o más componentes adicionales. Reivindicación 2: Una composición adecuada para la administración tópica, comprende una mezcla de a) la PVP-l a una concentración de inicio entre alrededor de 0,4% y alrededor de 12,5% en peso b) por lo menos un antiinflamatorio no esteroide (NSAID) seleccionado del grupo que consta de amfenac, bromfenac, fumarato de ketotifen, diclofenac, diclofenac sódico, flurbiprofen sádico, ketorolac, ketorolac trometamina, suprofeno, celecoxib, naproxeno, rofecoxib, y combinaciones y sales de los mismos, en donde después de un período de un mes después de mezclar el NSAID y la PVP-l para formar la composición, la concentración de PVP-l es de por lo menos 98% de la concentración inicial de PVP-I, y después de un período de seis meses después de la mezcla de NSAID y PVP-l para formar la composición, la concentración de PVP-l es de por lo menos 96% de la concentración de inicio de PVP-l. Reivindicación 3: Una composición adecuada para administración tópica, comprende una mezcla de a) PVP-l a una concentración inicial entre alrededor de 0,4% y alrededor de 12,5% en peso; y b) por lo menos un esteroide seleccionado del grupo que consta de dexametasona, alcohol de dexametasona, fosfato sódico de dexametasona, acetato de fluorometolona, alcohol de fluorometolona, etabonato de lotoprednol, medrisona, acetato de prednisolona, fosfato sódico de prednisolona, difluprednato, rimexolona, hidrocortisona, acetato de hidrocortisona, lodoxamida trometamina, y combinaciones y sales de los mismos; en donde después de a período de un mes después de mezclar el esteroide y la PVP-l es de por lo menos 98% de la concentración inicial de PVP-l, y después de un período de seis meses después de mezclar el esteroide y la PVP-l para formar la composición, la concentración de PVP-l es de por lo menos 96% de la concentración inicial de PVP-l.
ARP120103368A 2011-09-16 2012-09-13 Composiciones de yodo-povidona estable AR087857A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161535667P 2011-09-16 2011-09-16

Publications (1)

Publication Number Publication Date
AR087857A1 true AR087857A1 (es) 2014-04-23

Family

ID=47883771

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120103368A AR087857A1 (es) 2011-09-16 2012-09-13 Composiciones de yodo-povidona estable

Country Status (16)

Country Link
US (1) US20150164939A1 (es)
EP (2) EP2755477A4 (es)
JP (3) JP6539444B2 (es)
KR (2) KR20140077900A (es)
CN (2) CN107595879A (es)
AR (1) AR087857A1 (es)
AU (2) AU2012308424B2 (es)
BR (1) BR112014005487A2 (es)
CA (1) CA2847364C (es)
CL (2) CL2014000592A1 (es)
CO (1) CO6930368A2 (es)
EC (1) ECSP14013302A (es)
MX (1) MX2014002679A (es)
PE (1) PE20141676A1 (es)
TW (4) TW202023575A (es)
WO (1) WO2013040347A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX360666B (es) * 2011-05-12 2018-11-13 Foresight Biotherapeutics Inc Composiciones de yodopovidona estables con antiinflamatorios esteroides y no esteroides.
AU2013256064B2 (en) 2012-05-03 2018-01-04 Alcon Inc. Pharmaceutical nanoparticles showing improved mucosal transport
KR102140989B1 (ko) 2012-05-03 2020-08-04 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
CA2900652C (en) 2013-02-15 2021-05-04 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
KR102277833B1 (ko) 2013-02-20 2021-07-14 칼라 파마슈티컬스, 인크. 치료 화합물 및 그의 용도
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN106061261B (zh) 2013-11-01 2018-04-24 卡拉制药公司 治疗化合物的结晶形式及其用途
US11576973B2 (en) * 2015-10-25 2023-02-14 Iview Therapeutics, Inc. Pharmaceutical formulations that form gel in situ
JP2019533641A (ja) 2016-09-08 2019-11-21 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物の結晶形態およびその使用
WO2018048750A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509422A4 (en) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
JP6255134B1 (ja) * 2016-11-02 2017-12-27 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法
WO2018193093A1 (en) * 2017-04-21 2018-10-25 Novaliq Gmbh Iodine compositions
CN110559175A (zh) * 2019-08-27 2019-12-13 陈文龙 一种结膜囊消毒溶液及其使用方法和装置
US20230181625A1 (en) * 2021-12-14 2023-06-15 Harrow Ip, Llc Method and composition for treating infectious conjunctivitis
KR102859862B1 (ko) * 2023-03-31 2025-09-16 주식회사 퍼슨헬스케어 창상피복용 조성물 및 그 제조 방법
WO2025243071A1 (en) 2024-05-22 2025-11-27 Apex Laboratories Private Limited A medicinal composition of povidone iodine and a biopolymer and a process of making it

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886268A (en) 1972-05-30 1975-05-27 Synergistics Iodophor-steroid compound pharmaceutical compositions
US4113857A (en) 1977-05-16 1978-09-12 The Purdue Frederick Company Process for the preparation of iodophor compounds and methods for stabilizing iodophor pharmaceutical compositions containing the same
US4954351A (en) * 1983-03-02 1990-09-04 Euroceltique S.A. Method of producing standardized povidone iodine preparations and such preparations
US4996048A (en) 1988-11-30 1991-02-26 Euroceltique, S.A. Stabilizing packaged iodophor and minimizing leaching of iodine through packaging
US5232692A (en) * 1989-04-28 1993-08-03 Research And Education Institute, Inc. Povidone-iodine neonatal ophthalmic antimicrobial prophylactic agent
US5126127A (en) 1991-07-16 1992-06-30 Euroceltique, S.A. Stabilized PVP-I solutions
IL135222A (en) * 2000-03-22 2005-06-19 Univ Ben Gurion Compositions containing molecular iodine
KR20040101499A (ko) * 2002-05-03 2004-12-02 알콘, 인코퍼레이티드 암페낙 또는 네파페낙을 이용한 혈관 내피 성장 인자 매개혈관 장애 치료 방법
US20060280809A1 (en) * 2005-06-14 2006-12-14 Leshchiner Adele K Anti-infective iodine based compositions for otic and nasal use
US7767217B2 (en) * 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
US20090092574A1 (en) * 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
KR101805852B1 (ko) * 2007-12-04 2018-01-10 산텐 에스에이에스 덱사메타손 팔미테이트와 같은 코르티코스테로이드 전구약물을 포함하는 안과질환 치료용 조성물
US20090263345A1 (en) * 2008-01-28 2009-10-22 Foresight Biotherapeutics, Inc. Otic compositions for the treatment of infections of the internal and external ear in mammals
CN101965183A (zh) * 2008-02-21 2011-02-02 伊斯塔药品公司 作为佐剂的眼用nsaid
NZ603346A (en) * 2008-06-12 2014-05-30 Foresight Biotherapeutics Inc Povidone iodine, a novel alternative preservative for ophthalmic compositions
JP2010059058A (ja) * 2008-09-01 2010-03-18 Kowa Co 鎮痛・抗炎症剤含有外用剤
JP5410071B2 (ja) * 2008-10-07 2014-02-05 久光製薬株式会社 エステル化抑制剤及びエステル化抑制方法
WO2011084473A1 (en) * 2009-12-15 2011-07-14 Foresight Biotherapeutics, Inc. Non-irritating ophthalmic povidone-iodine compositions
MX360666B (es) * 2011-05-12 2018-11-13 Foresight Biotherapeutics Inc Composiciones de yodopovidona estables con antiinflamatorios esteroides y no esteroides.

Also Published As

Publication number Publication date
AU2016204700A1 (en) 2016-07-21
TW201325601A (zh) 2013-07-01
JP6539444B2 (ja) 2019-07-03
AU2012308424B2 (en) 2016-08-04
MX2014002679A (es) 2014-04-25
EP2755477A1 (en) 2014-07-23
JP2020007324A (ja) 2020-01-16
WO2013040347A1 (en) 2013-03-21
CA2847364A1 (en) 2013-03-21
CL2017001952A1 (es) 2018-03-16
BR112014005487A2 (pt) 2017-03-21
CO6930368A2 (es) 2014-04-28
JP2018024689A (ja) 2018-02-15
AU2012308424A1 (en) 2013-05-02
CN103889218A (zh) 2014-06-25
ECSP14013302A (es) 2014-05-31
KR20140077900A (ko) 2014-06-24
CN107595879A (zh) 2018-01-19
EP2755477A4 (en) 2015-05-06
EP3556372A1 (en) 2019-10-23
US20150164939A1 (en) 2015-06-18
JP2014526514A (ja) 2014-10-06
TW202126313A (zh) 2021-07-16
CL2014000592A1 (es) 2014-11-03
CA2847364C (en) 2020-08-25
KR20190099084A (ko) 2019-08-23
TW201808311A (zh) 2018-03-16
AU2016204700B2 (en) 2018-03-22
PE20141676A1 (es) 2014-11-06
TW202023575A (zh) 2020-07-01

Similar Documents

Publication Publication Date Title
AR087857A1 (es) Composiciones de yodo-povidona estable
CL2021000191A1 (es) Inhibidores de inflamasoma nlrp3
BR112014009087A2 (pt) formulações de etanercept estabilizadas com xilitol
MX385720B (es) Nuevos derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen.
CR20150629A (es) Compuestos químicos
DOP2014000085A (es) Derivados de (4-fenilimidazol-2-il)etilamina útiles como moduladores de canal de sodio
BR112015000578A2 (pt) moduladores da via do complemento e usos dos mesmos
UY33491A (es) ?Derivados de sulfonamida y sus sales farmacéuticamente aceptables para uso en medicina?.
BR112015000229A2 (pt) formulações aquosas estáveis de etanercept
EA201590053A1 (ru) Модуляторы пути системы комплемента и их применение
PE20130217A1 (es) Composiciones farmaceuticas y metodos para su elaboracion
ECSP13012538A (es) Combinaciones que contienen n-(2-arilamino)arilsulfonamida sustituida
BR112013000254A2 (pt) derivados heterocíclicos 1-fenil-substituídos e seu uso como moduladores do receptor de prostaglandina d2
ECSP24028270A (es) Compuestos espirocíclicos
PE20151979A1 (es) Compuestos quimicos
UA111357C2 (uk) Аналоги епоксіейкозатриєнової кислоти, композиція на їх основі, застосування для лікування захворювань та спосіб зниження гіпертонії та нефротоксичності (варіанти)
CR20190379A (es) Moduladores del receptor de estrógeno
BR112018001035A2 (pt) compostos de fenoxiacetamidas aneladas, sal farmaceuticamente aceitável, seu método de síntese, combinação de medicamento e uso dos mesmos
ECSP13012838A (es) Nuevos compuestos de benzodioxol-piperazina
BR112013017570A2 (pt) compostos de pirazola como antagonistas de crth2
UA110822C2 (uk) Піперидинілмонокарбонові кислоти як агоністи s1p1-рецепторів
PE20131327A1 (es) Forma cristalina delta de la sal de arginina de perindoprilo, su procedimiento de preparacion, y las composiciones farmaceuticas que la contienen
BR112016021471A8 (pt) derivados de ácido acético azaindol e seu uso como moduladores de receptor d2 de prosrtglandina
GT201400044A (es) 2-(croman-6-iloxi)-tiazoles sustituidos y su uso como productos farmacéuticos
PE20100560A1 (es) Nueva asociacion de ingredientes activos que contienen un farmaco antiinflamatorio, no esteroideo y un derivado de colchicosido

Legal Events

Date Code Title Description
FC Refusal