[go: up one dir, main page]

AR087118A1 - Metodo de preparacion de derivado de acido ciclohexano carboxilico - Google Patents

Metodo de preparacion de derivado de acido ciclohexano carboxilico

Info

Publication number
AR087118A1
AR087118A1 ARP120102500A ARP120102500A AR087118A1 AR 087118 A1 AR087118 A1 AR 087118A1 AR P120102500 A ARP120102500 A AR P120102500A AR P120102500 A ARP120102500 A AR P120102500A AR 087118 A1 AR087118 A1 AR 087118A1
Authority
AR
Argentina
Prior art keywords
compound
formula
preparation
obtaining
carboxylic acid
Prior art date
Application number
ARP120102500A
Other languages
English (en)
Inventor
Birrer Beat
Clarke Leo
Deichtmann Walter
Hayes John
Jeisy Julius
Lautz Christian
E Martin Rainer
Meade Michael
Pintao Joaquim
Scalone Michelangelo
Schaefer Juerguen
Smith Dennis
Staempfli Andreas
Veits Joachim
Walch Christian
Walsh Andrew
Zogg Andreas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR087118A1 publication Critical patent/AR087118A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso para la obtención de un compuesto de la fórmula (1) que es útil como compuesto intermedio en la obtención entre otros de compuestos farmacéuticamente activos. Reivindicación 1: Un proceso para la obtención del compuesto de la fórmula (1) que consiste en hacer reaccionar un compuesto de la fórmula (2) con una base, opcionalmente en presencia de agua. Reivindicación 14: El proceso según la reivindicación 1 ó 2 para la obtención de un compuesto de la fórmula (1) que consiste en hacer reaccionar un compuesto de la fórmula (2) con una base acuosa o una base inorgánica, opcionalmente en presencia de agua, para formar un compuesto de la fórmula (1) a través de un compuesto de la fórmula (3) que después se hidroliza para generar un compuesto de la fórmula (4) en la que M⁺ es un contraión alcalino, para obtener el compuesto de la fórmula (1).
ARP120102500A 2011-07-13 2012-07-11 Metodo de preparacion de derivado de acido ciclohexano carboxilico AR087118A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11173736 2011-07-13

Publications (1)

Publication Number Publication Date
AR087118A1 true AR087118A1 (es) 2014-02-12

Family

ID=46508343

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120102500A AR087118A1 (es) 2011-07-13 2012-07-11 Metodo de preparacion de derivado de acido ciclohexano carboxilico

Country Status (11)

Country Link
US (1) US8975438B2 (es)
EP (1) EP2731930A1 (es)
JP (2) JP2014522853A (es)
KR (1) KR20140039045A (es)
CN (2) CN107011148A (es)
AR (1) AR087118A1 (es)
BR (1) BR112014000613A2 (es)
CA (1) CA2839638A1 (es)
MX (1) MX2014000304A (es)
RU (1) RU2014102445A (es)
WO (1) WO2013007712A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6449235B2 (ja) 2013-03-27 2019-01-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 治療に対する応答性を予測するための遺伝マーカー
PT3174995T (pt) 2014-07-30 2020-10-15 Hoffmann La Roche Marcadores genéticos para prever o tipo de resposta ao tratamento com um fármaco de aumento do hdl ou mimetizador do hdl

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485117A (en) 1981-10-16 1984-11-27 Hudson Alan T Antiprotozoal compounds
SG59966A1 (en) * 1995-03-08 1999-02-22 Daicel Chem Process for producing a carboxylic acid
JP2894445B2 (ja) 1997-02-12 1999-05-24 日本たばこ産業株式会社 Ｃｅｔｐ活性阻害剤として有効な化合物
JPH11147850A (ja) * 1997-11-14 1999-06-02 Sumika Fine Chemicals Co Ltd ビフェニルカルボン酸類の製造方法
CA2345068C (en) * 1998-09-26 2009-11-17 Aventis Pharma Deutschland Gmbh Process for the preparation of .alpha.,.alpha.-dimethylphenylacetic acid from .alpha.,.alpha.-dimethylbenzyl cyanide under normal pressure
JP4546798B2 (ja) * 2004-09-30 2010-09-15 本州化学工業株式会社 エキソ型架橋脂環式モノオレフィンカルボン酸の製造方法
CN100338008C (zh) * 2005-04-20 2007-09-19 江苏省原子医学研究所 1－羧基－1－(3,5－二甲氧基苯基)－2－(4－r基苯基)乙烯及其制备方法
US7435849B2 (en) 2005-10-31 2008-10-14 Hoffmann-La Roche Inc. Process for the production of acid chlorides
CN101981001B (zh) * 2008-04-04 2016-06-08 弗·哈夫曼-拉罗切有限公司 制备环己烷甲酸衍生物的新方法
KR101290935B1 (ko) 2008-04-04 2013-07-29 에프. 호프만-라 로슈 아게 상응하는 사이클로헥세인카복스아마이드 유도체에 의한 사이클로헥세인카복실산 유도체의 신규한 제조 방법
KR20110008326A (ko) 2008-06-17 2011-01-26 에프. 호프만-라 로슈 아게 약학 활성 아미드의 제조에서 중간체로서의 1-(2-에틸-부틸)-사이클로헥산카복실산 에스터
CN101565369B (zh) * 2009-05-22 2012-10-03 江苏开元医药化工有限公司 一种3-溴-5-三氟甲基苯甲酸的制备方法
US20110004011A1 (en) 2009-07-01 2011-01-06 Declan Costello Novel process
CA2769960C (en) * 2009-08-04 2017-04-18 Chiesi Farmaceutici S.P.A. Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Also Published As

Publication number Publication date
JP2017095506A (ja) 2017-06-01
MX2014000304A (es) 2014-02-20
US8975438B2 (en) 2015-03-10
WO2013007712A1 (en) 2013-01-17
RU2014102445A (ru) 2015-08-20
CA2839638A1 (en) 2013-01-17
US20130018201A1 (en) 2013-01-17
BR112014000613A2 (pt) 2017-02-14
EP2731930A1 (en) 2014-05-21
CN103649046A (zh) 2014-03-19
CN107011148A (zh) 2017-08-04
JP2014522853A (ja) 2014-09-08
KR20140039045A (ko) 2014-03-31

Similar Documents

Publication Publication Date Title
AR092278A1 (es) Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
CY1119731T1 (el) Διαδικασια για την παρασκευη παραγωγων χολικου οξεος
MX2020010330A (es) Proceso para preparar un compuesto antiviral de formula i.
AR085155A1 (es) Procesos para preparar compuestos de quinolina y composiciones farmaceuticas que contienen dichos compuestos
HN2012000182A (es) Formulacion farmaceutica
WO2014128545A3 (en) An improved process for the preparation of dolutegravir
AR088018A1 (es) Proceso e intermediarios para preparar lapatinib
UA111142C2 (uk) Одержання заміщених похідних 2-фторакрилової кислоти
FR2979344B1 (fr) Procede de preparation de furfural
AR093406A1 (es) Metodo para la produccion de acido peracetico en equilibrio, y acido peracetico en equilibrio que se puede obtener con dicho metodo
CL2011000296A1 (es) Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados.
AR078916A1 (es) Procedimiento para la purificacion de paliperidona
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
PT2462098E (pt) Processos para a preparação de derivados de ácido 1-(2- halobifenil-4-il)-ciclopropanocarboxílico
AR088377A1 (es) Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
MX2011009898A (es) Proceso para la obtencion de derivados de acido propionico.
UA111868C2 (uk) Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
ECSP13012548A (es) Inhibidores de oxadiazol de la producción de leucotrienos.
PH12016500913A1 (en) Soap bar
AR087118A1 (es) Metodo de preparacion de derivado de acido ciclohexano carboxilico
MX342570B (es) Proceso para producir granulos que comprende una o mas sales de agentes complejantes.
UA117849C2 (uk) Спосіб одержання 3-заміщених складних ефірів (індол-1-іл)-оцтової кислоти
SG10201901578UA (en) Processes for the preparation of pyrimidinylcyclopentane compounds
EA201591487A1 (ru) Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью

Legal Events

Date Code Title Description
FB Suspension of granting procedure