AR073925A1 - Derivados 7- sustituidos de 3- carboxi- oxidiacino- quinolonas, su preparacion y su aplicacion como antibacterianos - Google Patents
Derivados 7- sustituidos de 3- carboxi- oxidiacino- quinolonas, su preparacion y su aplicacion como antibacterianosInfo
- Publication number
- AR073925A1 AR073925A1 ARP090100666A ARP090100666A AR073925A1 AR 073925 A1 AR073925 A1 AR 073925A1 AR P090100666 A ARP090100666 A AR P090100666A AR P090100666 A ARP090100666 A AR P090100666A AR 073925 A1 AR073925 A1 AR 073925A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- represent
- nrarb
- optionally substituted
- nhrc
- Prior art date
Links
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 229910003827 NRaRb Inorganic materials 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos de formula (1) en la que R1 representa H, OH, NH2 -(CH2)m-NRaRb (m = 0, 1 o 2), Ra y Rb representan H, alquilo C1-6 lineal, ramificado o cíclico, cicloalquilo C3-6-alquilo C1-6, Rc, S(O)2Rc, C(O)Rc, S(O)2Rd o C(O)Rd; o Ra y Rb forman con N un radical Rc; Rc representa un anillo saturado, insaturado o aromático de 5 o 6 vértices que incluye entre1 y 4 heteroátomos elegidos entre N, O y S, eventualmente sustituidos por 1 a 3 radicales alquilo C1-6, estando unido dicho anillo al átomo de N de -NRaRb si es el caso con un átomo de N o de C; Rd representa a un alquilo lineal, ramificado o cíclico C1-6, eventualmente sustituido por de 1 a 4 halogenos; o R1 representa Rc o CHReRc o CHReRd; Re representa H, OH, NH2, NHaIq C1-6 o Nalq2 C1-6, o NH-acilo C1-7 o NHRc; R2 representa H, (CH2)m-NraRb, Rc, CHReRc o CHReRd; y R'2 representa H; entendiéndose que R1 y R2 no pueden ser simultáneamente H o que R1 y R2 o R2 y R1 no pueden ser uno (CH2)m-NRaRb o Rc o H y el otro OH, o uno H y el otro NH2, o uno H y el otro (CH2)m-NRaRb, Ra y Rb representando H o alquilo o C(O)Rd, Rd representando alquilo o cicloalquilo no sustituido; R1 se define como anteriormente a excepcion del hidrogeno y R2 y R'2 representan gem dialquilo C1-6 o alquilo C1-6-oxima, o R2 y R'2 representan Rc o Rd y OH, NH2, NHRc o NHRf, siendo Rf un acilo C1-7; R1 representa hidrogeno y R2 y R'2 representan juntos alquilo C1-6-oxima o representan uno Rc y el otro OH, NH2, NHRc o NHRf; n es 0 o 1; R3 y R'3, representan alquilo C1-6 eventualmente sustituido por de 1 a 3 halogenos o R3 represente un alcoxi C1-6-carbonilo y R'3 representa H; R4 representa metilo eventualmente sustituido por halogeno; R5 representa H, alquilo C1-6 o arilalquilo C7-12; R6 representa H, fluor, NO2, CF3 o CN; bajo la forma de enantiomeros o de mezclas, así canto de sus sales de ácidos y bases. Su preparacion y su aplicacion como antibacterianos, tanto para medicina humana como veterinaria.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0801129A FR2928150A1 (fr) | 2008-02-29 | 2008-02-29 | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
| US4564508P | 2008-04-17 | 2008-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073925A1 true AR073925A1 (es) | 2010-12-15 |
Family
ID=39767082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100666A AR073925A1 (es) | 2008-02-29 | 2009-02-26 | Derivados 7- sustituidos de 3- carboxi- oxidiacino- quinolonas, su preparacion y su aplicacion como antibacterianos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7713965B2 (es) |
| EP (1) | EP2254893A1 (es) |
| JP (1) | JP2011513293A (es) |
| KR (1) | KR20100138978A (es) |
| CN (2) | CN101965354A (es) |
| AR (1) | AR073925A1 (es) |
| AU (1) | AU2009219868A1 (es) |
| BR (1) | BRPI0906048A2 (es) |
| CA (1) | CA2715728A1 (es) |
| CL (1) | CL2009000470A1 (es) |
| CO (1) | CO6251292A2 (es) |
| EA (1) | EA018348B1 (es) |
| FR (1) | FR2928150A1 (es) |
| IL (1) | IL207514A0 (es) |
| MX (1) | MX2010009511A (es) |
| NZ (1) | NZ587590A (es) |
| TW (1) | TWI391395B (es) |
| WO (1) | WO2009106967A1 (es) |
| ZA (1) | ZA201005934B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2928150A1 (fr) | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
| EP2145891A1 (en) * | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials |
| EP2338888A1 (en) | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| CN115448864B (zh) * | 2022-08-26 | 2023-12-22 | 上海方予健康医药科技有限公司 | 3-氟-3-（1-羟乙基）吡咯烷-1-羧酸叔丁酯的制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| ES2059335T3 (es) * | 1986-09-12 | 1994-11-16 | Hoffmann La Roche | Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento. |
| ZW16387A1 (en) * | 1986-09-12 | 1988-05-25 | Hoffmann La Roche | Tricyclic compounds |
| JP2844079B2 (ja) | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
| DE3906365A1 (de) | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| IE69269B1 (en) | 1989-04-28 | 1996-08-21 | Daiichi Seiyaku Co | Use of fluorine containing pyridone carboxylic acid derivatives for preparing a medicament for the treatment of HIV infections |
| AU5449590A (en) | 1989-04-28 | 1990-11-29 | Daiichi Pharmaceutical Co., Ltd. | Anti-hiv drug |
| US5342846A (en) * | 1990-12-05 | 1994-08-30 | Synphar Laboratories, Inc. | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents |
| JPH05194487A (ja) * | 1991-11-08 | 1993-08-03 | Kaken Pharmaceut Co Ltd | オキシム誘導体 |
| DE4234078A1 (de) | 1992-10-09 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| US5354747A (en) * | 1993-06-16 | 1994-10-11 | G. D. Searle & Co. | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
| TW252107B (es) * | 1993-08-27 | 1995-07-21 | Hokuriku Pharmacetical Co Ltd | |
| DE4329600A1 (de) * | 1993-09-02 | 1995-03-09 | Bayer Ag | Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate |
| DE4416622A1 (de) * | 1994-05-11 | 1995-11-16 | Bayer Ag | 8-Amino-10-(azabicycloalkyl)-pyrido[1,2,3-d.e] [1,3,4]benzoxa-diazinderivate |
| DE69509442T2 (de) | 1994-06-16 | 1999-09-02 | Lg Chemical Ltd. | Chinolincarbonsäurederivate mit 7-(4-Amino-methyl-3-oxim)-pyrrolidin-Substituenten und Verfahren zu ihrer Herstellung |
| US5576314A (en) * | 1994-12-12 | 1996-11-19 | Allelix Biopharmaceuticals Inc. | Bicyclic nonane and decane compounds having dopamine receptor affinity |
| GB9601356D0 (en) * | 1996-01-24 | 1996-03-27 | Pfizer | Novel compound |
| EP0982030A3 (en) * | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands |
| WO2000053594A1 (en) * | 1999-03-10 | 2000-09-14 | Daiichi Pharmaceutical Co., Ltd. | Aminomethylpyrrolidine derivatives having aromatic substituents |
| SE9904108D0 (sv) * | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | Nya föreningar |
| ES2249489T3 (es) * | 2000-12-14 | 2006-04-01 | THE PROCTER & GAMBLE COMPANY | Quinolonas antimicrobianas. |
| WO2003048136A1 (en) * | 2001-11-29 | 2003-06-12 | Merck & Co., Inc. | Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof |
| SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| US20050239852A1 (en) * | 2002-08-02 | 2005-10-27 | Ab Science | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| EP1631570A1 (en) * | 2003-03-12 | 2006-03-08 | Abbott Laboratories | Naphthyridine derivatives as antibacterial agents |
| US20070155714A1 (en) | 2003-04-30 | 2007-07-05 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| WO2005026165A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| WO2005026154A1 (en) | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| PL1684750T3 (pl) * | 2003-10-23 | 2010-10-29 | Ab Science | 2-Aminoarylooksazole jako inhibitory kinazy tyrozynowej |
| US20080039466A1 (en) * | 2004-01-30 | 2008-02-14 | Ab Science | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors |
| US20070232644A1 (en) | 2004-09-07 | 2007-10-04 | Pfizer Inc. | Inhibitors of the Hiv Integrase Enzyme |
| MX2007004661A (es) | 2004-10-18 | 2007-06-22 | Lilly Co Eli | Derivados de 1-(hetero)aril-3-amino-pirrolidina para usarse como antagonistas del receptor mglur3. |
| AP2007004061A0 (en) | 2005-01-10 | 2007-08-31 | Galloway & Company | Pyrrolopyrazoles, potent kinase inhibitors |
| JP2009501217A (ja) | 2005-07-15 | 2009-01-15 | アストラゼネカ アクチボラグ | 治療薬 |
| CA2618057A1 (en) | 2005-08-11 | 2007-02-22 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN101305011B (zh) | 2005-09-09 | 2011-03-02 | 史密丝克莱恩比彻姆公司 | 吡啶衍生物及其在治疗精神障碍中的用途 |
| FR2896416B1 (fr) | 2006-01-24 | 2010-08-13 | Vetoquinol | Composition anti-infectieuse comprenant un compose de type pyrido (3,2,1-ij)-benzoxadiazine |
| FR2928150A1 (fr) | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
-
2008
- 2008-02-29 FR FR0801129A patent/FR2928150A1/fr not_active Withdrawn
-
2009
- 2009-02-23 TW TW098105615A patent/TWI391395B/zh not_active IP Right Cessation
- 2009-02-26 BR BRPI0906048-0A patent/BRPI0906048A2/pt not_active IP Right Cessation
- 2009-02-26 EA EA201071014A patent/EA018348B1/ru not_active IP Right Cessation
- 2009-02-26 AU AU2009219868A patent/AU2009219868A1/en not_active Abandoned
- 2009-02-26 JP JP2010548204A patent/JP2011513293A/ja active Pending
- 2009-02-26 WO PCT/IB2009/000363 patent/WO2009106967A1/fr not_active Ceased
- 2009-02-26 AR ARP090100666A patent/AR073925A1/es not_active Application Discontinuation
- 2009-02-26 CN CN2009801064489A patent/CN101965354A/zh active Pending
- 2009-02-26 CA CA2715728A patent/CA2715728A1/en not_active Abandoned
- 2009-02-26 MX MX2010009511A patent/MX2010009511A/es active IP Right Grant
- 2009-02-26 KR KR1020107021609A patent/KR20100138978A/ko not_active Withdrawn
- 2009-02-26 NZ NZ587590A patent/NZ587590A/en not_active IP Right Cessation
- 2009-02-26 EP EP09715639A patent/EP2254893A1/fr not_active Withdrawn
- 2009-02-26 CN CN2013103398590A patent/CN103467490A/zh active Pending
- 2009-02-27 CL CL2009000470A patent/CL2009000470A1/es unknown
- 2009-02-27 US US12/394,918 patent/US7713965B2/en not_active Expired - Fee Related
-
2010
- 2010-08-09 IL IL207514A patent/IL207514A0/en unknown
- 2010-08-19 ZA ZA2010/05934A patent/ZA201005934B/en unknown
- 2010-09-29 CO CO10120821A patent/CO6251292A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI391395B (zh) | 2013-04-01 |
| WO2009106967A1 (fr) | 2009-09-03 |
| MX2010009511A (es) | 2010-11-25 |
| ZA201005934B (en) | 2011-05-25 |
| EA018348B1 (ru) | 2013-07-30 |
| CN103467490A (zh) | 2013-12-25 |
| EA201071014A1 (ru) | 2011-04-29 |
| TW200944532A (en) | 2009-11-01 |
| FR2928150A1 (fr) | 2009-09-04 |
| AU2009219868A1 (en) | 2009-09-03 |
| EP2254893A1 (fr) | 2010-12-01 |
| BRPI0906048A2 (pt) | 2015-06-30 |
| IL207514A0 (en) | 2010-12-30 |
| KR20100138978A (ko) | 2010-12-31 |
| US7713965B2 (en) | 2010-05-11 |
| JP2011513293A (ja) | 2011-04-28 |
| US20090221565A1 (en) | 2009-09-03 |
| CN101965354A (zh) | 2011-02-02 |
| CA2715728A1 (en) | 2009-09-03 |
| CL2009000470A1 (es) | 2009-10-23 |
| CO6251292A2 (es) | 2011-02-21 |
| NZ587590A (en) | 2012-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |