AR073773A1 - Metodo para producir decitabina protegida beta-enriquecida. - Google Patents
Metodo para producir decitabina protegida beta-enriquecida.Info
- Publication number
- AR073773A1 AR073773A1 ARP090103836A ARP090103836A AR073773A1 AR 073773 A1 AR073773 A1 AR 073773A1 AR P090103836 A ARP090103836 A AR P090103836A AR P090103836 A ARP090103836 A AR P090103836A AR 073773 A1 AR073773 A1 AR 073773A1
- Authority
- AR
- Argentina
- Prior art keywords
- protected
- formula
- producing beta
- decitabin
- enriched
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 abstract 2
- 229960003603 decitabine Drugs 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- PDWIQYODPROSQH-PYHARJCCSA-N 2-deoxy-D-ribofuranose Chemical compound OC[C@H]1OC(O)C[C@@H]1O PDWIQYODPROSQH-PYHARJCCSA-N 0.000 abstract 1
- MFEFTTYGMZOIKO-UHFFFAOYSA-N 5-azacytosine Chemical compound NC1=NC=NC(=O)N1 MFEFTTYGMZOIKO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Un método para producir decitabina protegida beta-enriquecida de formula (1) donde cada uno de los R1 es un grupo alquilo C1-8 o un grupo arilo, cada uno de los R2 y R3 es independientemente hidrogeno o Si(R4)3, y R4 es independientemente un grupo alquilo C1-8 o un grupo arilo opcionalmente sustituido, que comprende: a) acoplar una 2-desoxi-ribofuranosa protegida de formula (2), donde cada uno de los R1 es segun se definio anteriormente, y R5 es un grupo alquilcarbonilo, arilcarbonilo, alquilsulfonilo, fluoroalquilsulfonilo o grupo arilsulfonilo, con una 5-azacitosina protegida, de formula (3), donde cada uno de los R4 es segun se definio anteriormente, en presencia de un solvente orgánico y un catalizador para formar una mezcla de reaccion que comprende a la decitabina protegida de formula (1); y b) enfriar la mezcla de reaccion del paso a) con una base orgánica; donde la base orgánica es soluble en el solvente orgánico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10257108P | 2008-10-03 | 2008-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073773A1 true AR073773A1 (es) | 2010-12-01 |
Family
ID=42073911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103836A AR073773A1 (es) | 2008-10-03 | 2009-10-05 | Metodo para producir decitabina protegida beta-enriquecida. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2341772B1 (es) |
| JP (1) | JP2012504652A (es) |
| CN (1) | CN102209467B (es) |
| AR (1) | AR073773A1 (es) |
| AU (1) | AU2009298175A1 (es) |
| ES (1) | ES2421233T3 (es) |
| HR (1) | HRP20130652T1 (es) |
| IL (1) | IL212110A0 (es) |
| WO (1) | WO2010040056A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8232387B2 (en) * | 2009-08-18 | 2012-07-31 | Scinopharm Taiwan, Ltd. | Process for the preparation of cladribine |
| CN102827224B (zh) * | 2011-06-16 | 2016-09-28 | 江苏豪森药业集团有限公司 | 一种地西他滨的合成与工业化生产方法 |
| CN104761605B (zh) * | 2014-01-03 | 2019-03-26 | 江苏豪森药业集团有限公司 | 地西他滨母液回收生产工艺方法 |
| CN106831917B (zh) * | 2016-12-21 | 2020-05-19 | 连云港恒运药业有限公司 | 地西他滨中间体的制备方法 |
| CN106831916B (zh) * | 2017-02-06 | 2019-12-06 | 抚州市星辰药业有限公司 | 一种β-胸苷的合成方法 |
| CN110028537A (zh) * | 2018-01-11 | 2019-07-19 | 上海百灵医药科技有限公司 | 一种地西他滨的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366987A (en) * | 1991-08-22 | 1994-11-22 | Warner-Lambert Company | Isoxazolyl-substituted alkyl amide ACAT inhibitors |
| CN101415719A (zh) * | 2003-03-20 | 2009-04-22 | 微生物化学及药品有限公司 | 生产2’-脱氧-β-L-核苷的方法 |
| US7250416B2 (en) * | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| EP2048151A1 (en) * | 2007-10-10 | 2009-04-15 | Cilag AG | Method for producing nucleosides by direct glycosylation of the nucleoside base |
| CN101821278B (zh) * | 2008-01-03 | 2012-03-28 | 南京华狮化工有限公司 | 一种合成地西他滨的方法 |
-
2009
- 2009-10-02 JP JP2011530269A patent/JP2012504652A/ja active Pending
- 2009-10-02 AU AU2009298175A patent/AU2009298175A1/en not_active Abandoned
- 2009-10-02 EP EP09818570.5A patent/EP2341772B1/en active Active
- 2009-10-02 ES ES09818570T patent/ES2421233T3/es active Active
- 2009-10-02 WO PCT/US2009/059385 patent/WO2010040056A1/en not_active Ceased
- 2009-10-02 CN CN200980144487.8A patent/CN102209467B/zh not_active Expired - Fee Related
- 2009-10-02 HR HRP20130652AT patent/HRP20130652T1/hr unknown
- 2009-10-05 AR ARP090103836A patent/AR073773A1/es unknown
-
2011
- 2011-04-03 IL IL212110A patent/IL212110A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20130652T1 (en) | 2013-08-31 |
| EP2341772B1 (en) | 2013-04-17 |
| CN102209467B (zh) | 2014-03-12 |
| IL212110A0 (en) | 2011-06-30 |
| JP2012504652A (ja) | 2012-02-23 |
| EP2341772A1 (en) | 2011-07-13 |
| WO2010040056A1 (en) | 2010-04-08 |
| EP2341772A4 (en) | 2012-03-28 |
| AU2009298175A1 (en) | 2010-04-08 |
| CN102209467A (zh) | 2011-10-05 |
| ES2421233T3 (es) | 2013-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |