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AR073404A1 - Anticuerpos anti-receptor il-6, composiciones que los contienen y metodos para producirlos - Google Patents

Anticuerpos anti-receptor il-6, composiciones que los contienen y metodos para producirlos

Info

Publication number
AR073404A1
AR073404A1 ARP090103711A ARP090103711A AR073404A1 AR 073404 A1 AR073404 A1 AR 073404A1 AR P090103711 A ARP090103711 A AR P090103711A AR P090103711 A ARP090103711 A AR P090103711A AR 073404 A1 AR073404 A1 AR 073404A1
Authority
AR
Argentina
Prior art keywords
tocilizumab
methods
compositions
antibodies
receiver
Prior art date
Application number
ARP090103711A
Other languages
English (en)
Inventor
Hiroyuki Tsunoda
Hirotake Shiraiwa
Tetsuo Kojima
Tomoyuki Igawa
Tatsuhiko Tachibana
Yoshinobu Higuchi
Mika Sakurai
Shinya Ishii
Atsuhiko Maeda
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42059767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073404(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR073404A1 publication Critical patent/AR073404A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)

Abstract

Composiciones farmacéuticas que comprenden moléculas de segunda generacion que son superiores a tocilizumab, por alteracion de las secuencias de aminoácidos de las regiones variable y constante de tocilizumab, que es un anticuerpo IgG1 anti-receptor del IL-6humanizado para aumentar la capacidad para neutralizar antígenos y para incrementar la farmacocinética, de modo tal que se ejerce un efecto terapéutico con una menor frecuencia de administracion, y se logran mejoras de la inmunogenicidad, seguridad y propiedades fisicoquímicas (estabilidad y homogeneidad). También se proporcionan métodos para producir estas composiciones farmacéuticas. Se han generado moléculas de segunda generacion que son superiores a tocilizumab mediante una combinacion apropiada de estas alteraciones de la secuencia de aminoácidos en los dominios CDR, regiones variables y regiones constantes.
ARP090103711A 2008-09-26 2009-09-25 Anticuerpos anti-receptor il-6, composiciones que los contienen y metodos para producirlos AR073404A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008248213 2008-09-26
JP2009060806 2009-03-13
JP2009067925 2009-03-19

Publications (1)

Publication Number Publication Date
AR073404A1 true AR073404A1 (es) 2010-11-03

Family

ID=42059767

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP090103711A AR073404A1 (es) 2008-09-26 2009-09-25 Anticuerpos anti-receptor il-6, composiciones que los contienen y metodos para producirlos
ARP220102433A AR127010A2 (es) 2008-09-26 2022-09-08 Anticuerpo, moléculas relacionadas, célula huesped, método de preparación y composición farmacéutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP220102433A AR127010A2 (es) 2008-09-26 2022-09-08 Anticuerpo, moléculas relacionadas, célula huesped, método de preparación y composición farmacéutica

Country Status (36)

Country Link
US (11) US8562991B2 (es)
EP (1) EP2330193B1 (es)
JP (2) JP4550938B2 (es)
KR (2) KR101690334B1 (es)
CN (2) CN101849006B (es)
AR (2) AR073404A1 (es)
AU (1) AU2009290162B2 (es)
BR (1) BRPI0905076B8 (es)
CA (2) CA2699834C (es)
CL (1) CL2011000632A1 (es)
CO (1) CO6362048A2 (es)
CR (1) CR20110204A (es)
DK (1) DK2330193T3 (es)
EC (1) ECSP11011003A (es)
ES (1) ES2546800T3 (es)
FI (1) FIC20210049I1 (es)
FR (1) FR21C1054I2 (es)
HR (1) HRP20150857T1 (es)
HU (2) HUE027533T2 (es)
IL (1) IL211850A0 (es)
LT (1) LTC2330193I2 (es)
LU (1) LUC00241I2 (es)
MA (1) MA32707B1 (es)
MX (1) MX2010003256A (es)
MY (1) MY153908A (es)
NL (1) NL301152I2 (es)
NO (1) NO2021048I1 (es)
NZ (1) NZ592214A (es)
PE (1) PE20120079A1 (es)
PL (1) PL2330193T3 (es)
PT (1) PT2330193E (es)
RU (1) RU2430111C3 (es)
SI (1) SI2330193T1 (es)
TW (1) TWI440469B (es)
WO (1) WO2010035769A1 (es)
ZA (1) ZA201103027B (es)

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KR101922788B1 (ko) 2007-09-26 2018-11-27 추가이 세이야쿠 가부시키가이샤 항체 정상영역 개변체
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WO2009125825A1 (ja) 2008-04-11 2009-10-15 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
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