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AR073031A1 - Composiciones terapeuticas que contienen macitentan - Google Patents

Composiciones terapeuticas que contienen macitentan

Info

Publication number
AR073031A1
AR073031A1 ARP090103113A ARP090103113A AR073031A1 AR 073031 A1 AR073031 A1 AR 073031A1 AR P090103113 A ARP090103113 A AR P090103113A AR P090103113 A ARP090103113 A AR P090103113A AR 073031 A1 AR073031 A1 AR 073031A1
Authority
AR
Argentina
Prior art keywords
pharmaceutically acceptable
compound
acceptable salts
acceptable salt
agonist
Prior art date
Application number
ARP090103113A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41346591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073031(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR073031A1 publication Critical patent/AR073031A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente se relaciona con un producto que contiene un compuesto de formula (1) o una sal farmacéuticamente aceptable de este compuesto, en combinacion con al menos un compuesto que tiene propiedades de agonista del receptor prostaciclina (IP), o una sal farmacéuticamente aceptable del mismo. Reivindicacion 2: Un producto de acuerdo con la reivindicacion 1, en el cual el compuesto que tiene propiedades de agonista del receptor de prostaciclina (IP) es seleccionado de entre treprostinil y sus sales farmacéuticamente aceptables, epoprostenol y sus sales farmacéuticamente aceptables, iloprost y sus sales farmacéuticamente aceptables, beraprost y sus sales farmacéuticamente aceptables, 2-{4-[(5,6-difenilpirazin-2- il)(isopropil)amino]butoxi}-N-(metilsulfonil)acetamida y sus sales farmacéuticamente aceptables, y ácido {4-[(5,6-difenilpirazin-2-il)(isopropil)amino]butoxi)acético y sus sales farmacéuticamente aceptables. Reivindicacion 5: Un producto que contiene macitentan o una sal farmacéuticamente aceptable de este compuesto, en combinacion con al menos un compuesto que tiene propiedades de agonista del receptor de prostaciclina (IP), o una sal farmacéuticamente aceptable del mismo, para uso terapéutico, de manera simultánea, separada o durante un periodo de tiempo, en el tratamiento de una enfermedad en la cual está involucrada la endotelina. Reivindicacion 9: Un producto de acuerdo con alguna de las reivindicaciones 5 a 8, en el cual la enfermedad en la cual está involucrada la endotelina es seleccionada de entre hipertension, hipertension pulmonar, arteriopatía diabética, falla cardíaca, disfuncion eréctil, angina pectoris y fibrosis pulmonar.
ARP090103113A 2008-08-13 2009-08-12 Composiciones terapeuticas que contienen macitentan AR073031A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2008053252 2008-08-13

Publications (1)

Publication Number Publication Date
AR073031A1 true AR073031A1 (es) 2010-10-06

Family

ID=41346591

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103113A AR073031A1 (es) 2008-08-13 2009-08-12 Composiciones terapeuticas que contienen macitentan

Country Status (30)

Country Link
US (3) US8809334B2 (es)
EP (2) EP3300729B1 (es)
JP (3) JP5764061B2 (es)
KR (1) KR101678699B1 (es)
CN (1) CN102099026B (es)
AR (1) AR073031A1 (es)
AU (1) AU2009280843B2 (es)
BR (1) BRPI0917661B8 (es)
CA (1) CA2731370C (es)
CY (2) CY1119826T1 (es)
DK (2) DK2315587T3 (es)
ES (2) ES2652590T3 (es)
HK (1) HK1253355B (es)
HR (2) HRP20171917T1 (es)
HU (2) HUE036071T2 (es)
IL (1) IL211143A0 (es)
LT (2) LT2315587T (es)
MA (1) MA32614B1 (es)
MX (1) MX350011B (es)
MY (1) MY178894A (es)
NO (1) NO2315587T3 (es)
NZ (1) NZ591601A (es)
PL (2) PL3300729T3 (es)
PT (2) PT2315587T (es)
RU (1) RU2519161C2 (es)
SI (2) SI3300729T1 (es)
SM (2) SMT201900740T1 (es)
TW (1) TWI446911B (es)
WO (1) WO2010018549A2 (es)
ZA (1) ZA201101900B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101313395B1 (ko) 2005-09-12 2013-10-02 액테리온 파마슈티칼 리미티드 피리미딘-설파마이드를 함유하는 안정한 제약학적 조성물
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
LT2246336T (lt) * 2008-02-28 2020-08-25 Nippon Shinyaku Co., Ltd. Fibrozės inhibitorius
RU2519161C2 (ru) 2008-08-13 2014-06-10 Актелион Фармасьютиклз Лтд Терапевтические композиции, содержащие мацитентан
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9794795B1 (en) 2016-04-29 2017-10-17 Corning Optical Communications Wireless Ltd Implementing a live distributed antenna system (DAS) configuration from a virtual DAS design using an original equipment manufacturer (OEM) specific software system in a DAS
EP3554507A1 (en) 2016-12-14 2019-10-23 Respira Therapeutics, Inc. Methods and compositions for treatment of pulmonary hypertension and other lung disorders
KR20210046018A (ko) * 2018-09-14 2021-04-27 파모사 바이오팜 인코포레이티드 약산성 약물의 방출 제어를 위한 약제학적 조성물 및 이의 용도
CN113194953A (zh) 2018-12-21 2021-07-30 埃科特莱茵药品有限公司 用于治疗肺动脉高血压的药物组合物
TW202042818A (zh) 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物
ES2994089T3 (en) 2019-11-29 2025-01-17 Actelion Pharmaceuticals Ltd Initial triple combination therapy with macitentan, tadalafil, and selexipag for treating pulmonary arterial hypertension
WO2021126884A1 (en) 2019-12-16 2021-06-24 Tenax Therapeutics, Inc. LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-pEF)
EP4456897A4 (en) 2021-12-31 2025-12-10 Tenax Therapeutics Inc ORAL FORMULATIONS OF LEVOSIMENDAN FOR THE TREATMENT OF PULMONARY HYPERTENSION WITH HEART FAILURE AND PRESERVED EJECTION FRACTION

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1097239A (en) 1976-05-11 1981-03-10 Salvador Moncada Enzymatic preparation of prostacyclin and its salts
DE2845770A1 (de) 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc 5,6,7−トリノル−4,8−インタ−m−フエニレンPGI↓2誘導体
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
NZ525614A (en) * 2000-12-18 2005-03-24 Actelion Pharmaceuticals Ltd Novel sulfamides and their use as endothelin receptor antagonists
HUP0303315A2 (hu) * 2000-12-19 2004-01-28 Merck Patent Gmbh. Pirazolo [4,3-d] pirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandinszármazékokat tartalmazó gyógyszerkészítmények
DE10100426B4 (de) 2001-01-08 2006-04-06 Steag Hamatech Ag Verfahren und Vorrichtung zum Zusammenfügen von Substraten
TWI316055B (es) * 2001-04-26 2009-10-21 Nippon Shinyaku Co Ltd
WO2004017993A1 (en) 2002-08-12 2004-03-04 Actelion Pharmaceuticals Ltd Combination of prostacyclin or prostacyclin analogues and endothelin receptor antagonists for the treatment of pulmonary arterial hypertension
ES2320649T3 (es) * 2002-12-02 2009-05-27 Actelion Pharmaceuticals Ltd. Pirimidin-sulfamidas y su uso como antagonistas de receptores de endotelina.
US20050101608A1 (en) * 2003-09-24 2005-05-12 Santel Donald J. Iloprost in combination therapies for the treatment of pulmonary arterial hypertension
TW200628467A (en) * 2004-11-11 2006-08-16 Actelion Pharmaceuticals Ltd Novel sulfamides
KR101313395B1 (ko) * 2005-09-12 2013-10-02 액테리온 파마슈티칼 리미티드 피리미딘-설파마이드를 함유하는 안정한 제약학적 조성물
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
DK2254570T3 (da) 2008-02-20 2014-02-03 Actelion Pharmaceuticals Ltd Kombination omfattende paclitaxel til behandling af ovariecancer
RU2519161C2 (ru) 2008-08-13 2014-06-10 Актелион Фармасьютиклз Лтд Терапевтические композиции, содержащие мацитентан

Also Published As

Publication number Publication date
BRPI0917661A2 (pt) 2015-12-01
PT2315587T (pt) 2018-01-31
EP3300729B1 (en) 2019-10-09
WO2010018549A3 (en) 2010-07-29
ES2763176T3 (es) 2020-05-27
JP2015180683A (ja) 2015-10-15
JP5764061B2 (ja) 2015-08-12
DK2315587T3 (en) 2018-01-02
LT3300729T (lt) 2020-01-10
HK1253355B (en) 2020-06-19
AU2009280843B2 (en) 2015-03-05
US9597331B2 (en) 2017-03-21
ES2652590T3 (es) 2018-02-05
NZ591601A (en) 2012-12-21
SMT201700592T1 (it) 2018-03-08
CY1122641T1 (el) 2021-03-12
EP2315587A2 (en) 2011-05-04
IL211143A0 (en) 2011-04-28
US20160022678A1 (en) 2016-01-28
US8809334B2 (en) 2014-08-19
PT3300729T (pt) 2020-01-20
ZA201101900B (en) 2012-08-29
MY178894A (en) 2020-10-21
TWI446911B (zh) 2014-08-01
BRPI0917661B1 (pt) 2019-12-17
MX2011001625A (es) 2011-03-29
RU2011109084A (ru) 2012-09-20
JP5956025B2 (ja) 2016-07-20
CA2731370A1 (en) 2010-02-18
EP3300729A1 (en) 2018-04-04
MX350011B (es) 2017-08-22
HRP20171917T1 (hr) 2018-02-09
SI3300729T1 (sl) 2020-02-28
HK1253355A1 (en) 2019-06-14
DK3300729T3 (da) 2020-01-20
TW201010985A (en) 2010-03-16
EP2315587B1 (en) 2017-10-25
CY1119826T1 (el) 2018-06-27
AU2009280843A1 (en) 2010-02-18
NO2315587T3 (es) 2018-03-24
HUE036071T2 (hu) 2018-06-28
KR20110045006A (ko) 2011-05-03
HRP20192204T1 (hr) 2020-03-06
SMT201900740T1 (it) 2020-01-14
JP2015187148A (ja) 2015-10-29
PL2315587T3 (pl) 2018-03-30
HUE047767T2 (hu) 2020-05-28
US20110136818A1 (en) 2011-06-09
JP5956026B2 (ja) 2016-07-20
PL3300729T3 (pl) 2020-04-30
CA2731370C (en) 2017-03-14
CN102099026A (zh) 2011-06-15
US9173881B2 (en) 2015-11-03
LT2315587T (lt) 2018-01-10
KR101678699B1 (ko) 2016-11-23
RU2519161C2 (ru) 2014-06-10
BRPI0917661B8 (pt) 2021-05-25
SI2315587T1 (en) 2018-04-30
WO2010018549A2 (en) 2010-02-18
CN102099026B (zh) 2012-08-29
US20140329824A1 (en) 2014-11-06
MA32614B1 (fr) 2011-09-01
JP2011530581A (ja) 2011-12-22

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