AR072442A1 - Metodo para la terapia del cancer, uso, kit - Google Patents
Metodo para la terapia del cancer, uso, kitInfo
- Publication number
- AR072442A1 AR072442A1 ARP090100051A ARP090100051A AR072442A1 AR 072442 A1 AR072442 A1 AR 072442A1 AR P090100051 A ARP090100051 A AR P090100051A AR P090100051 A ARP090100051 A AR P090100051A AR 072442 A1 AR072442 A1 AR 072442A1
- Authority
- AR
- Argentina
- Prior art keywords
- kit
- cancer therapy
- treatment
- cancer
- medicament
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000011275 oncology therapy Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicacion 1: El uso del compuesto de formula (1) o una sal farmacéuticamente aceptable del mismo, para la fabricacion de un medicamento destinado al tratamiento del cáncer, en particular de tumores solidos. Reivindicacion 16: Un método para la fabricacion de un medicamento destinado al tratamiento del cáncer, en particular de tumores solidos, caracterizado porque se emplea el compuesto de la formula (1) en una cantidad terapéuticamente eficaz. Reivindicacion 34: Los métodos y usos segun la reivindicacion 33 para el tratamiento de cáncer pancreático.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2044708P | 2008-01-11 | 2008-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072442A1 true AR072442A1 (es) | 2010-09-01 |
Family
ID=40365425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100051A AR072442A1 (es) | 2008-01-11 | 2009-01-08 | Metodo para la terapia del cancer, uso, kit |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20090181944A1 (es) |
| EP (1) | EP2244713A1 (es) |
| JP (3) | JP5612482B2 (es) |
| KR (2) | KR20140007979A (es) |
| CN (1) | CN101909633B (es) |
| AR (1) | AR072442A1 (es) |
| AU (1) | AU2009203776A1 (es) |
| BR (1) | BRPI0906831A2 (es) |
| CA (1) | CA2710913A1 (es) |
| CL (1) | CL2009000040A1 (es) |
| CR (1) | CR11510A (es) |
| IL (1) | IL206361A0 (es) |
| MA (1) | MA33076B1 (es) |
| RU (1) | RU2010133489A (es) |
| TW (1) | TW200936139A (es) |
| WO (1) | WO2009087130A1 (es) |
| ZA (1) | ZA201004859B (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2669693C (en) | 2006-11-15 | 2018-06-12 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| CA2743436C (en) | 2008-11-24 | 2017-10-31 | Massachusetts Eye & Ear Infirmary | Pathways to generate hair cells |
| US8309299B2 (en) * | 2010-05-19 | 2012-11-13 | Hoffmann-La Roche Inc. | Combination therapy and method for assessing resistance to treatment |
| KR101330184B1 (ko) | 2010-10-15 | 2013-11-15 | 성균관대학교산학협력단 | 감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물 |
| WO2012050370A2 (ko) * | 2010-10-15 | 2012-04-19 | 성균관대학교산학협력단 | 감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물 |
| US20120114638A1 (en) * | 2010-11-08 | 2012-05-10 | John Boylan | Combination therapy |
| US20120225860A1 (en) * | 2011-03-02 | 2012-09-06 | John Frederick Boylan | Method for administration of a gamma secretase inhibitor |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙(氟烷基)-1,4-苯二氮呯酮化合物 |
| JO3148B1 (ar) | 2011-07-27 | 2017-09-20 | Lilly Co Eli | مركب مثبط لإشارات مسار notch |
| CA2884309A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity |
| HK1211875A1 (en) | 2012-09-07 | 2016-06-03 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| US9249157B2 (en) | 2012-09-21 | 2016-02-02 | Bristol-Myers Squibb Company | Tricyclic heterocycle compounds |
| CN104854094A (zh) | 2012-09-21 | 2015-08-19 | 百时美施贵宝公司 | 氟烷基二苯并二氮杂*酮化合物 |
| US9242940B2 (en) | 2012-09-21 | 2016-01-26 | Bristol-Myers Squibb Company | N-substituted bis(fluoroalkyl)-1,4-benzodiazepinone compounds |
| US9273075B2 (en) | 2012-09-21 | 2016-03-01 | Bristol-Myers Squibb Company | Prodrugs of 1,4-benzodiazepinone compounds |
| CN105308030A (zh) | 2012-09-21 | 2016-02-03 | 百时美施贵宝公司 | 烷基、氟烷基-1,4-苯并二氮杂*酮化合物 |
| CN104797569A (zh) | 2012-09-21 | 2015-07-22 | 百时美施贵宝公司 | 取代的1,5-苯并二氮杂*酮化合物 |
| CN104822677A (zh) | 2012-09-21 | 2015-08-05 | 百时美施贵宝公司 | 氟烷基-1,4-苯并二氮杂*酮化合物 |
| TWI614238B (zh) | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥 |
| WO2014047397A1 (en) | 2012-09-21 | 2014-03-27 | Bristol-Myers Squibb Company | Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch|inhibitors |
| JP2016515625A (ja) * | 2013-04-04 | 2016-05-30 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 増殖性疾患を治療するための併用療法 |
| WO2015095116A1 (en) * | 2013-12-17 | 2015-06-25 | Rush University Medical Center | Compositions and methods for treating diabetic nephropathy |
| US20170314027A1 (en) | 2014-08-06 | 2017-11-02 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| WO2016069906A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| KR20180117628A (ko) | 2016-01-29 | 2018-10-29 | 매사추세츠 아이 앤드 이어 인퍼머리 | 내이 지지 세포의 확장 및 분화 및 그의 사용 방법 |
| WO2017180385A1 (en) | 2016-04-12 | 2017-10-19 | Eli Lilly And Company | Combination therapy with notch and pi3k/mtor inhibitors for use in treating cancer |
| KR102362222B1 (ko) | 2016-05-16 | 2022-02-11 | 더 제너럴 하스피탈 코포레이션 | 폐 상피 공학에서 인간 기도 줄기 세포 |
| JP7194022B2 (ja) | 2016-05-20 | 2022-12-21 | イーライ リリー アンド カンパニー | Notch阻害剤とPD-1またはPD-L1阻害剤との併用療法 |
| AU2017376109A1 (en) | 2016-12-16 | 2019-07-11 | Pipeline Therapeutics, Inc. | Methods of treating cochlear synaptopathy |
| MA50564A (fr) | 2017-11-06 | 2020-09-16 | Hutchinson Fred Cancer Res | Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase |
| KR102094442B1 (ko) | 2018-06-28 | 2020-03-27 | 성균관대학교산학협력단 | 알쯔하이머성 치매의 예방 또는 치료용 물질 및 이를 포함하는 조성물 |
| WO2022067185A1 (en) * | 2020-09-27 | 2022-03-31 | Veru Inc. | Methods of treating prostate cancer with minimal side effects |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ras相關疾病或病症之組合療法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6012A (en) * | 1849-01-09 | Lithographing co | ||
| KR100838852B1 (ko) * | 2003-09-09 | 2008-06-16 | 에프. 호프만-라 로슈 아게 | 감마-세크리테이즈의 활성을 차단하는 말론아미드 유도체 |
| US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
| JP2008530232A (ja) * | 2005-02-15 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 化学療法剤、il−2および場合により抗cd20抗体の組み合わせを使用してリンパ腫を処置する方法 |
| EP1888051A2 (en) * | 2005-05-17 | 2008-02-20 | MERCK SHARP & DOHME LTD. | Sulphonamido-substituted cyclohexyl sulphones for treatment of cancer |
| US20080058316A1 (en) * | 2006-02-27 | 2008-03-06 | The Johns Hopkins University | Cancer treatment with gama-secretase inhibitors |
-
2009
- 2009-01-05 RU RU2010133489/15A patent/RU2010133489A/ru unknown
- 2009-01-05 KR KR1020137035150A patent/KR20140007979A/ko not_active Ceased
- 2009-01-05 CA CA2710913A patent/CA2710913A1/en not_active Abandoned
- 2009-01-05 US US12/348,464 patent/US20090181944A1/en not_active Abandoned
- 2009-01-05 CN CN2009801017331A patent/CN101909633B/zh not_active Expired - Fee Related
- 2009-01-05 BR BRPI0906831A patent/BRPI0906831A2/pt not_active IP Right Cessation
- 2009-01-05 EP EP09700208A patent/EP2244713A1/en not_active Withdrawn
- 2009-01-05 MA MA33027A patent/MA33076B1/fr unknown
- 2009-01-05 WO PCT/EP2009/050047 patent/WO2009087130A1/en not_active Ceased
- 2009-01-05 AU AU2009203776A patent/AU2009203776A1/en not_active Abandoned
- 2009-01-05 JP JP2010541761A patent/JP5612482B2/ja not_active Expired - Fee Related
- 2009-01-05 KR KR1020107014569A patent/KR20100101624A/ko not_active Ceased
- 2009-01-08 AR ARP090100051A patent/AR072442A1/es unknown
- 2009-01-08 TW TW098100518A patent/TW200936139A/zh unknown
- 2009-01-09 CL CL2009000040A patent/CL2009000040A1/es unknown
-
2010
- 2010-06-14 IL IL206361A patent/IL206361A0/en unknown
- 2010-06-17 CR CR11510A patent/CR11510A/es not_active Application Discontinuation
- 2010-07-09 ZA ZA2010/04859A patent/ZA201004859B/en unknown
-
2013
- 2013-07-25 JP JP2013154790A patent/JP2013241443A/ja not_active Ceased
-
2014
- 2014-06-13 JP JP2014122580A patent/JP2014221772A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014221772A (ja) | 2014-11-27 |
| US20090181944A1 (en) | 2009-07-16 |
| CA2710913A1 (en) | 2009-07-16 |
| WO2009087130A1 (en) | 2009-07-16 |
| JP2013241443A (ja) | 2013-12-05 |
| CR11510A (es) | 2010-09-13 |
| EP2244713A1 (en) | 2010-11-03 |
| RU2010133489A (ru) | 2012-02-20 |
| MA33076B1 (fr) | 2012-03-01 |
| TW200936139A (en) | 2009-09-01 |
| JP5612482B2 (ja) | 2014-10-22 |
| KR20100101624A (ko) | 2010-09-17 |
| CN101909633B (zh) | 2012-05-30 |
| JP2011509273A (ja) | 2011-03-24 |
| CL2009000040A1 (es) | 2010-02-12 |
| KR20140007979A (ko) | 2014-01-20 |
| IL206361A0 (en) | 2010-12-30 |
| AU2009203776A1 (en) | 2009-07-16 |
| ZA201004859B (en) | 2011-03-30 |
| BRPI0906831A2 (pt) | 2019-09-24 |
| CN101909633A (zh) | 2010-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |