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AR071719A1 - Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion - Google Patents

Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion

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Publication number
AR071719A1
AR071719A1 ARP090101711A ARP090101711A AR071719A1 AR 071719 A1 AR071719 A1 AR 071719A1 AR P090101711 A ARP090101711 A AR P090101711A AR P090101711 A ARP090101711 A AR P090101711A AR 071719 A1 AR071719 A1 AR 071719A1
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AR
Argentina
Prior art keywords
alkyl
3alkyl
piperazin
alkyloxy
oxo
Prior art date
Application number
ARP090101711A
Other languages
English (en)
Inventor
Bradford S Hamilton
Matthias Eckhardt
Frank Himmelsbach
Joerg Kley
Thorsten Lehmann-Lintz
Stefan Peters
Original Assignee
Boehringer Ingelheim Int
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Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR071719A1 publication Critical patent/AR071719A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Particularmente, los compuestos son inhibidores de la 11b-hidroxiesteroide deshidrogenasa (HSD) 1 y, por lo tanto, son adecuados para el tratamiento y la prevencion de enfermedades que pueden estar influenciadas por la inhibicion de esta enzima, tales como enfermedades metabolicas, en particular diabetes de tipo 2, obesidad y dislipidemia. Reivindicacion 1: Compuestos caracterizados porque tienen formula (1) en la que X representa CH o N; m, n, o, independientemente entre s¡, representan 0, 1 o 2, donde la estructura nucleo de azacicloalqueno bic¡clico de formula general (1) anillada con el anillo A y unida al grupo carbonilo est  opcionalmente sustituida con 1, 2, o m s sustituyentes, preferiblemente con 1 a 5, seleccionados independientemente entre s¡ entre el grupo que consiste en R11 y R12; A representa un anillo benzo, que est  opcionalmente sustituido con uno a cuatro sustituyentes seleccionados independientemente entre s¡ entre R1 o donde 2  tomos de C adyacentes est n opcionalmente sustituidos con R2 y R3 y uno o dos  tomos de carbono est n opcionalmente sustituidos independientemente con sustituyentes seleccionados entre R1; o un anillo pirido, que est  opcionalmente sustituido con uno a tres sustituyentes, preferiblemente 1, 2, 3 o 4 sustituyentes, seleccionados independientemente entre s¡ entre R1 o donde 2  tomos de C adyacentes est n opcionalmente sustituidos con R2 y R3 y un  tomo de carbono est  opcionalmente sustituido con R1; o un anillo pirrolo, furo, tieno, piridazino o pirazino donde cada uno de dichos anillos est  opcionalmente sustituido con uno o dos sustituyentes, seleccionados independientemente entre s¡ entre R1 o donde 2  tomos de C adyacentes de cada uno de dichos anillos est n opcionalmente sustituidos con R2 y R3; o un anillo pirimido, que est  opcionalmente sustituido con uno o dos sustituyentes, seleccionados independientemente entre s¡ entre R1, o un anillo pirazolo, imidazo, oxazolo, tiazolo, isoxazolo o isotiazolo donde cada uno de dichos anillos est  opcionalmente sustituido con R1; o un anillo 1,2,3-triazolo sustituido con RN; y B representa un grupo cicloalquilo monoc¡clico de 5 a 8 miembros, espiroc¡clico de 8 a 12 miembros, bic¡clico de 6 a 12 miembros o tric¡clico de 9 a 15 miembros, estando cada uno de ellos opcionalmente saturado o parcialmente insaturado, y donde 1 o 2 grupos -CH2- se reemplazan opcionalmente por -NRN-, y donde 1 a 4 grupos -CH2-, que no est n unidos directamente uno a otro, se reemplazan opcionalmente independientemente entre s¡ por O, S, carbonilo o sulfonilo, y donde 1 o 2 grupos -CH se reemplazan opcionalmente por N, y donde cada grupo cicloalquilo mencionado anteriormente est  opcionalmente sustituido con uno o m s sustituyentes seleccionados independientemente entre s¡ entre L1, y donde cada uno de dichos grupos cicloalquilo est  opcionalmente sustituido con 1 o 2 sustituyentes seleccionados independientemente entre s¡ entre L2, y donde 2  tomos de C adyacentes de cada uno de dichos grupos cicloalquilo est n opcionalmente sustituidos con L3 y L4, y donde 2  tomos de C adyacentes de cada uno de dichos grupos cicloalquilo est n opcionalmente sustituidos con L5 y L6, con la condicion de que dos de L3 a L6 no puedan unirse al mismo  tomo de carbono; RN independientemente entre s¡, representa hidrogeno, alquilo C1-6, alquenilo C3-6, alquinilo C3-6, cicloalquilo C3-6, (het)arilo, alquilcarbonilo C1-4, alquiloxicarbonilo C1-4, alquilaminocarbonilo C1-4, di-(alquil C1-3)aminocarbonilo, alquilsulfonilo C1-4, (het)arilcarbonilo, (het)arilaminocarbonilo o (het)arilsulfonilo, donde cada grupo alquilo, alquenilo y alquinilo est  opcionalmente mono o polisustituido con fluor, y est  opcionalmente monosustituido con hidroxi, alcoxi C1-4, alquilsulfanilo C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, amino, alquilamino C1-4, di-(alquil C1-4)amino, alquilcarbonilamino C1-4, ciano, carboxi, alcoxicarbonilo C1-4, aminocarbonilo, alquilaminocarbonilo C1-4, di-(alquil C1-4)aminocarbonilo o (het)arilo; R1 representa fluor, cloro, bromo, yodo, ciano, nitro, alquilo C1-4, hidroxi, alquiloxi C1-4, alqueniloxi C3-6, difluorometilo, trifluorometilo, difluorometoxi, trifluorometoxi, 2,2,2-trifluoro-1-hidroxietilo, 2,2,2-trifluoro-1-hidroxi-1-metiletilo, 2,2,2-trifluoro-1-hidroxi-1-(trifluorometil)etilo, cicloalquilo C3-6, cicloalquiloxi C3-6, cicloalquil C3-6-alquilo C1-3, cicloalquil C3-6-alquiloxi C1-3, tetrahidrofurano-3-iloxi, tetrahidropiran-3-iloxi, tetrahidropiran-4-iloxi, tetrahidrofuranoil-alquiloxi C1-3, tetrahidropiranil C1-3, (het)arilo, (het)ariloxi, (het)aril-alquilo C1-3, (het)aril-alquiloxi C1-3, (het)ariloxi-alquilo C1-3, alquil C1-3-carbonilo, (het)aril-carbonilo, amino, alquilamino C1-3, di-(alquil C1-3)amino, pirrolidin-1-ilo, 2-oxo-pirrolidin-1-ilo, piperidin-1-ilo, 2-oxo-piperidin-1-ilo, morfolin-4-ilo, 3-oxo-morfolin-4-ilo, piperazin-1-ilo, 2-oxo-piperazin-1-ilo, 3-oxo-piperazin-1-ilo, 4-(alquil C1-3)-piperazin-1-ilo, 4-(alquilcarbonil C1-4)-piperazin-1-ilo, 4-(cicloalquilcarbonil C3-6)-piperazin-1-ilo, 4-(alquiloxicarbonil C1-4)-piperazin-1-ilo, 4-(alquilsulfonil C1-4)-piperazin-1-ilo, 2-oxo-4-(alquil C1-3)-piperazin-1-ilo, 3-oxo-4-(alquil C1-3)-piperazin-1-ilo, alquil C1-3-carbonilamino, (het)aril-carbonilamino, (het)aril-alquil C1-3-carbonilamino, alquiloxi C1-3-carbonilamino, aminocarbonilamino, alquil C1-3-aminocarbonilamino, di-(alquil C1-3)aminocarbonilamino, pirrolidin-1-il-carbonilamino, piperidin-1-il-carbonilamino, morfolin-4-il-carbonilamino, piperazin-1-il-carbonilamino, 4-(alquil C1-3)-piperazin-1-il-carbonilamino, alquil C1-3-sulfonilamino, aminosulfonilamino, alquil C1-3amino-sulfonilamino, di-(alquil C1-3)amino-sulfonilamino, pirrolidin-1-il-sulfonilamino, piperidin-1-il-sulfonilamino, morfolin-4-il-sulfonilamino, piperazin-1-il-sulfonilamino, 4-(alquil C1-3)-piperazin-1-il-sulfonilamino, (alquiloxi C1-3-carbonilamino)carbonilamino, (het)arilsulfonilamino, (het)aril-alquil C1-3-sulfonilamino, N-(alquil C1-3)-alquil C1-3-carbonilamino, N-(alquil C1-3)-(het)arilcarbonilamino, N(alquil C1-3)-(het)aril-alquil C1-3-carbonilamino, N-(alquil C1-3)-alquiloxi C1-3-carbonilamino, N-(aminocarbonil)-alquilamino C1-3, N-(alquil C1-3-aminocarbonil)-alquilamino C1-3, N-[di-(alquil C1-3)aminocarbonil]-alquilamino C1-3, N-(alquil C1-3)-alquil C1-3-sulfonilamino, N-(alquil C1-3)-(het)arilsulfonilamino, N(alquil C1-3)-(het)aril-alquil C1-3-sulfonilamino, oxo-imidazolidin-1-ilo, 2,4-dioxo-imidazolidin-1-ilo, 2,5-dioxo-imidazolidin-1-ilo, 2-oxo-hexahidropirimidin-1-ilo, donde el  tomo de nitrogeno de la posicion 3 de los grupos mencionados anteriormente est  opcionalmente sustituido con metilo o etilo, (hidroxiimino)aminometilo, (alquiloxiimino C1-3)aminometilo, carboxi, alquiloxi C1-3-carbonilo, aminocarbonilo, alquil C1-3-aminocarbonilo, di-(alquil C1-3)-aminocarbonilo, pirrolidin-1-il-carbonilo, piperidin-1-il-carbonilo, morfolin-4-il-carbonilo, piperazin-1-il-carbonilo, 4-(alquil C1-3)-piperazin-1-il-carbonilo, carboxi-alquilo C1-3, alquiloxi C1-3-carbonil-alquilo C1-3, ciano-alquilo C1-3, aminocarbonil-alquilo C1-3, alquil C1-3-aminocarbonil-alquilo C1-3, di-(alquil C1-3)-aminocarbonil-alquilo C1-3, pirrolidin-1-il-carbonil-alquilo C1-3, piperidin-1-il-carbonil-alquilo C1-3, morfolin-4-iI-carbonil-alquilo C1-3, piperazin-1-il-carbonilalquilo C1-3, 4-(alquil C1-3)-piperazin-1-il-carbonil-alquilo C1-3, carboxi-alquiloxi C1-3, alquiloxi C1-3-carbonil-alquiloxi C1-3, ciano-alquiloxi C1-3, aminocarbonil-alquiloxi C1-3, alquil C1-3-aminocarbonil-alquiloxi C1-3, di-(alquil C1-3)-aminocarbonil-alquiloxi C1-3, pirrolidin-1-il-carbonil-alquiloxi C1-3, piperidin-1-il-carbonil-alquiloxi C1-3, morfolin-4-iI-carbonil-alquiloxi C1-3, piperazin-1-il-carbonilalquiloxi C1-3, 4-(alquil C1-3)-piperazin-1-il-carbonil-alquiloxi C1-3, hidroxi-alquilo C1-3, alquiloxi C1-3-alquilo C1-3, amino-alquilo C1-3, alquilamino C1-3-alquilo C1-3, di-(alquil C1-3)-amino-alquilo C1-3, pirrolidin-1-il-alquilo C1-3, alquil C1-4carbonil-amino-alquilo C1-3, N-(alquil C1-3)-alquil C1-4carbonil-amino-alquilo C1-3, 2-oxo-pirrolidin-1-iI-alquilo C1-3, piperidin-1-il-alquilo C1-3, 2-oxo-piperidin-1-il-alquilo C1-3, morfolin-4-il-alquilo C1-3, 3-oxo-morfolin-4-il-alquilo C1-3, piperazin-1-il-alquilo C1-3, 2-oxo-piperazin-1-il-alquilo C1-3, 3-oxo-piperazin-1-il-alquilo C1-3, 4-(alquil C1-3)-piperazin-1-il-alquilo C1-3, 2-oxo-4-(alquil C1-3)-piperazin-1-iI-alquilo C1-3, 3-oxo-4-(alquil C1-3)-piperazin-1-il-alquilo C1-3, hidroxi-alquiloxi C1-3, alquiloxi C1-3-alquiloxi C1-3, alquilsulfanil C1-3-alquiloxi C1-3, alquilsulfinil C1-3-alquiloxi C1-3, alquilsulfonil C1-3-alquiloxi C1-3, amino-alquiloxi C1-3 , alquilamino C1-3-alquiloxi C1-3, di-(alquil C1-3)-amino-alquiloxi C1-3, pirrolidin-1-il-alquiloxi C1-3, 2-oxo-pirrolidin-1-il-alquiloxi C1-3, piperidin-1-il-alquiloxi C1-3, 2-oxo-piperidin-1-il-alquiloxi C1-3, morfolin-4-il-alquiloxi C1-3, 3-oxo-morfolin-4-il-alquiloxi C1-3, piperazin-1-il-alquiloxi C1-3, 2-oxo-piperazin-1-il-alquiloxi C1-3, 3-oxo-piperazin-1-il-alquiloxi C1-3, 4-(alquil C1-3)-piperazin-1-il-alquiloxi C1-3, 2-oxo-4-(alquil C1-3)-piperazin-1-il-alquiloxi C1-3, 3-oxo-4-(alquil C1-3)-piperazin-1-il-alquiloxi C1-3, alquilsulfanilo C1-3, alquilsulfinilo C1-3, alquilsulfonilo C1-3, alquilsulfoniloxi C1-3, (het)arilsulfonilo, (het)arilsulfoniloxi, trifluorometilsulfanilo, trifluorometilsulfinilo, trifluorometilsulfonilo, aminosulfonilo, alquil C1-3-aminosulfonilo, di-(alquil C1-3)-aminosulfonilo, pirrolidin-1-il-sulfonilo, piperidin-1-il-sulfonilo, morfolin-4-il-sulfonilo, piperazin-1-il-sulfonilo o 4-(alquil C1-3)-piperazin-1-il-sulfonilo-, donde los heterociclos saturados y los anillos cicloalquilo mencionados anteriormente est n opcionalmente sustituidos con uno o dos grupos seleccionados independientemente entre fluor, alquilo C1-3, alcoxi C1-3, alcoxi C1-3-alquilo C1-3 e hidroxi; R2, R3 est n unidos entre s¡ para formar un grupo puente metilendioxi, etilendioxi o alquileno C3-5,
ARP090101711A 2008-05-13 2009-05-12 Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion AR071719A1 (es)

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US (2) US8765780B2 (es)
EP (1) EP2288596B1 (es)
JP (1) JP5711115B2 (es)
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CA (1) CA2724214A1 (es)
CL (1) CL2009001151A1 (es)
TW (1) TW200950780A (es)
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