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AR070865A1 - Combinaciones de un conjugado anticuerpo- farmaco anti- her2 y agentes quimioterapeuticos y los metodos de uso - Google Patents

Combinaciones de un conjugado anticuerpo- farmaco anti- her2 y agentes quimioterapeuticos y los metodos de uso

Info

Publication number
AR070865A1
AR070865A1 ARP090100844A ARP090100844A AR070865A1 AR 070865 A1 AR070865 A1 AR 070865A1 AR P090100844 A ARP090100844 A AR P090100844A AR P090100844 A ARP090100844 A AR P090100844A AR 070865 A1 AR070865 A1 AR 070865A1
Authority
AR
Argentina
Prior art keywords
carcinoma
antibody
disorders
mcc
trastuzumab
Prior art date
Application number
ARP090100844A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40858064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR070865(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR070865A1 publication Critical patent/AR070865A1/es

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Las combinaciones del conjugado anticuerpo-fármaco de trastuzumab-MCC-DM1 y los agentes quimioterapéuticos, que incluyen estereoisomeros, isomeros geométricos, tautomeros, solvatos, metabolitos y sales farmacéuticamente aceptables de los mismos, son utiles para la inhibicion del crecimiento celular del tumor y para el tratamiento de trastornos, tales como los de cáncer mediado por HER2 y KDR (receptor 1 de VEGFR). Se describen los métodos de uso de dichas combinaciones para el diagnostico, prevencion o tratamiento in vitro, in situ e in vivo de dichos trastornos en células de mamíferos o de las afecciones patologicas asociadas. Reivindicacion 24: Una composicion farmacéutica que comprende trastuzumab-MCC-DM1, un agente quimioterapéutico seleccionado entre un anticuerpo inhibidor de la dimerizacion de HER2, un anticuerpo anti-VEGF, 5-FU, carboplatino, lapatinib, ABT-869, docetaxel, GDC-0941 y GNE-390; y uno o más vehículos, transportadores, diluyentes o excipientes farmacéuticamente aceptables. Reivindicacion 28: El uso de una combinacion terapéutica en la fabricacion de un medicamento para el tratamiento de cáncer seleccionado entre el cáncer de seno, ovario, cuello del utero, prostata, testículos, tracto genitourinario, esofago, laringe, glioblastoma, neuroblastoma, estomago, piel, queratoacantoma, pulmon, carcinoma epidermoide, carcinoma de células grandes, carcinoma de células no pequenas (NSCLC), carcinoma de células pequenas, adenocarcinoma de pulmon, hueso, colon, adenoma, páncreas, adenocarcinoma, tiroides, carcinoma folicular, carcinoma no diferenciado, carcinoma papilar, seminoma, melanoma, sarcoma, carcinoma de vejiga, carcinoma de hígado y de conductos biliares, carcinoma de rinon, trastornos mieloides, trastornos linfoides, de células pilosas, de cavidad bucal y faringe (oral), labio, lengua, boca, faringe, intestino delgado, colon y recto, intestino grueso, recto, cerebro y sistema nervioso central, linfoma de Hodgkin y leucemia; donde la combinacion terapéutica se administra a un mamífero como formulacion combinada o por alternancia y comprende una cantidad terapéuticamente eficaz de trastuzumab-MCC-DM1 y una cantidad terapéuticamente eficaz de un agente quimioterapéutico seleccionado entre un anticuerpo inhibidor de la dimerizacion de HER2, un anticuerpo anti-VEGF, 5-FU, carboplatino, lapatinib, ABT-869, docetaxel, GDC-0941 y GNE-390. Reivindicacion 29: Un artículo fabricado para el tratamiento de trastornos hiperproliferantes que comprende: a) una combinacion terapéutica se administra a un mamífero como formulacion combinada o por alternancia y comprende una cantidad terapéuticamente eficaz de trastuzumab-MCC-DM1 y una cantidad terapéuticamente eficaz de un agente quimioterapéutico seleccionado entre un anticuerpo inhibidor de la dimerizacion de HER2 un anticuerpo anti-VEGF, 5-FU, carboplatino, lapatinib, ABT-869, docetaxel, GDC-0941, y GNE-390; y b) las instrucciones de uso.
ARP090100844A 2008-03-18 2009-03-10 Combinaciones de un conjugado anticuerpo- farmaco anti- her2 y agentes quimioterapeuticos y los metodos de uso AR070865A1 (es)

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