AR078960A1 - Sales del acido 5-(aminopirimidin-4-il)-2-(2,4-dicloro fenil)-1h-pirrol-3-carboxilico como inhibidor de cdc7 - Google Patents
Sales del acido 5-(aminopirimidin-4-il)-2-(2,4-dicloro fenil)-1h-pirrol-3-carboxilico como inhibidor de cdc7Info
- Publication number
- AR078960A1 AR078960A1 ARP100104167A ARP100104167A AR078960A1 AR 078960 A1 AR078960 A1 AR 078960A1 AR P100104167 A ARP100104167 A AR P100104167A AR P100104167 A ARP100104167 A AR P100104167A AR 078960 A1 AR078960 A1 AR 078960A1
- Authority
- AR
- Argentina
- Prior art keywords
- diclor
- aminopirimidin
- carboxilico
- pirrol
- phenyl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 102100034744 Cell division cycle 7-related protein kinase Human genes 0.000 title abstract 3
- 101000945740 Homo sapiens Cell division cycle 7-related protein kinase Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- -1 salts L-aspartate Chemical class 0.000 abstract 2
- 108091007914 CDKs Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a nuevas sales cristalinas de un inhibidor de CDC7 o CDC7/CDKs, a una nueva forma cristalina de la base libre correspondiente, a un proceso para su preparacion, a hidratos, solvatos y polimorfos de estas nuevas formas de sales, a su uso en terapia y a composiciones farmacéuticas que las contienen. Estas sales cristalinas son seleccionadas entre las sales L-aspartato, hemifumarato, clorhidrato, maleato, mesilato, sulfato, L-tartrato o fosfato de amida del ácido 5-(2-aminopirimidin-4-il)-2-(2,4-diclorofenil)-1H-pirrol-3-carboxílico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09175648 | 2009-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078960A1 true AR078960A1 (es) | 2011-12-14 |
Family
ID=43513935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104167A AR078960A1 (es) | 2009-11-11 | 2010-11-10 | Sales del acido 5-(aminopirimidin-4-il)-2-(2,4-dicloro fenil)-1h-pirrol-3-carboxilico como inhibidor de cdc7 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8658662B2 (es) |
| EP (1) | EP2499128B1 (es) |
| JP (1) | JP5856971B2 (es) |
| CN (1) | CN102666528B (es) |
| AR (1) | AR078960A1 (es) |
| ES (1) | ES2543098T3 (es) |
| TW (1) | TW201125861A (es) |
| WO (1) | WO2011057960A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013026137B1 (pt) * | 2011-04-19 | 2020-12-01 | Nerviano Medical Sciences S.R.L | pirimidinil-pirróis substituídos ativos como inibidores da quinase |
| US8912200B2 (en) | 2011-07-28 | 2014-12-16 | Nerviano Medical Sciences S.R.L. | Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0202463D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| US8263604B2 (en) | 2006-03-27 | 2012-09-11 | Nerviano Medical Sciences S.R.L. | Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors |
| TWI426074B (zh) | 2008-04-30 | 2014-02-11 | Nerviano Medical Sciences Srl | ５－（２－胺基－嘧啶－４－基）－２－芳基－１ｈ－吡咯－３－羧醯胺之製造方法 |
-
2010
- 2010-11-05 CN CN201080050807.6A patent/CN102666528B/zh not_active Expired - Fee Related
- 2010-11-05 ES ES10774212.4T patent/ES2543098T3/es active Active
- 2010-11-05 WO PCT/EP2010/066873 patent/WO2011057960A1/en not_active Ceased
- 2010-11-05 JP JP2012538288A patent/JP5856971B2/ja not_active Expired - Fee Related
- 2010-11-05 US US13/508,648 patent/US8658662B2/en active Active
- 2010-11-05 EP EP10774212.4A patent/EP2499128B1/en active Active
- 2010-11-08 TW TW099138312A patent/TW201125861A/zh unknown
- 2010-11-10 AR ARP100104167A patent/AR078960A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2543098T3 (es) | 2015-08-14 |
| JP5856971B2 (ja) | 2016-02-10 |
| WO2011057960A1 (en) | 2011-05-19 |
| JP2013510811A (ja) | 2013-03-28 |
| US8658662B2 (en) | 2014-02-25 |
| EP2499128B1 (en) | 2015-06-03 |
| CN102666528B (zh) | 2014-04-16 |
| US20120245189A1 (en) | 2012-09-27 |
| HK1175780A1 (en) | 2013-07-12 |
| CN102666528A (zh) | 2012-09-12 |
| EP2499128A1 (en) | 2012-09-19 |
| TW201125861A (en) | 2011-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |