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AR078178A1 - Compuestos de benceno-carboxamida como inhibidores de la enzima conver-tidora de tnf - Google Patents

Compuestos de benceno-carboxamida como inhibidores de la enzima conver-tidora de tnf

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Publication number
AR078178A1
AR078178A1 ARP100103373A ARP100103373A AR078178A1 AR 078178 A1 AR078178 A1 AR 078178A1 AR P100103373 A ARP100103373 A AR P100103373A AR P100103373 A ARP100103373 A AR P100103373A AR 078178 A1 AR078178 A1 AR 078178A1
Authority
AR
Argentina
Prior art keywords
radical
alkyl
substituted
alkoxy
hydroxyl
Prior art date
Application number
ARP100103373A
Other languages
English (en)
Inventor
Laurence Clary
Jean-Claude Pascal
Original Assignee
Galderma Res & Dev
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Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of AR078178A1 publication Critical patent/AR078178A1/es

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Compuestos de benceno-carboxamida y su uso en composiciones farmacéuticas previstas para el uso en medicina humana o veterinaria o a su uso en composiciones cosméticas. Reivindicacion 1: Compuesto de la formula general 1 presentada a continuacion: (1) en donde: R1 y R2 son idénticos o diferentes y representan radicales alquilo o forman un anillo con el átomo de nitrogeno al cual están unidos, dicho anillo está representado por la siguiente formula: (2), X, m y n tienen los significados dados más abajo; R3 es un átomo de hidrogeno o un radical alquilo, inferior que comprende de 1 a 4 átomos de carbono; R4 es un radical alquilo que comprende de 1 a 10 átomos de carbono, un radical alquilo substituido con uno o más radicales seleccionados entre un átomo de halogeno, un radical alcoxi y un radical hidroxilo, un radical alquenilo que comprende de 2 a 10 átomos de carbono, un radical alquenilo substituido con uno o más radicales seleccionados entre un átomo de halogeno, un radical alcoxi y un radical hidroxilo, un radical alquinilo que comprende de 2 a 10 átomos de carbono, un radical alquinilo substituido con uno o más radicales seleccionados entre un átomo de halogeno, un radical alcoxi y un radical hidroxilo, un radical arilo, un radical arilo substituido con uno o más grupos de átomos seleccionados entre un alquilo, un alcoxi, un arilo, un halogeno, un hidroxilo, un ciano, un trifluorometilo y un nitro, un radical aralquilo, un radical aralquilo substituido, un radical heterocíclico, un radical heterocíclico substituido con uno o más grupos de átomos seleccionados entre un alquilo, un alcoxi, un halogeno, a hidroxilo, un ciano, un trifluorometilo y un nitro, un radical cicloalquilo, un radical cicloalquilo substituido con uno o más radicales seleccionados entre un átomo de halogeno, un radical alcoxi y un radical hidroxilo, un radical heteroarilo, un radical heteroarilo substituido con uno o más grupos de átomos seleccionados, por ejemplo, entre un alquilo, un alcoxi, un arilo, un arilo substituido, un halogeno, un hidroxilo, un ciano, un trifluorometilo y un nitro, un radical heteroaralquilo, un radical heteroaralquilo substituido con uno o más grupos de átomos seleccionados entre un alquilo, un alcoxi, un halogeno, un hidroxilo, un ciano, un trifluorometilo y un nitro; X representa un átomo de oxígeno, un radical -CH2-, un radical -CH-(CH2)p-NR5R6, un átomo de azufre, un radical SO o un radical SO2, R5, R6 y p tienen los significados dados más abajo; R5 y R6, que pueden ser idénticos o diferentes, representan un átomo de hidrogeno, un radical alquilo que comprende de 1 a 10 átomos de carbono, un radical alquilo substituido con uno o más radicales seleccionados entre un átomo de halogeno, un radical alcoxi y un radical hidroxilo, un radical arilo o un radical arilo substituido con uno o más grupos de átomos seleccionados entre un alquilo, un alcoxi, un arilo, un halogeno, un hidroxilo, un ciano, un trifluorometilo o un nitro; m puede tomar los valores de 0 o 1; n puede tomar los valores de 0, 1, 2 o 3; p puede tomar los valores de 0, 1 o 2; y también las sales de adicion de los compuestos de formula general 1 con un ácido farmacéuticamente aceptable, las sales de adicion de los compuestos de formula general 1 con una base farmacéuticamente aceptable y los enantiomeros de los compuestos de la formula general 1.
ARP100103373A 2009-09-17 2010-09-16 Compuestos de benceno-carboxamida como inhibidores de la enzima conver-tidora de tnf AR078178A1 (es)

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US27236809P 2009-09-17 2009-09-17
FR0956377A FR2950056B1 (fr) 2009-09-17 2009-09-17 Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique

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AR078178A1 true AR078178A1 (es) 2011-10-19

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US (1) US9266848B2 (es)
EP (1) EP2477969B1 (es)
JP (1) JP2013505216A (es)
AR (1) AR078178A1 (es)
CA (1) CA2771679A1 (es)
ES (1) ES2442772T3 (es)
FR (1) FR2950056B1 (es)
WO (1) WO2011033010A1 (es)

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EP3199534B1 (en) 2016-02-01 2018-09-05 Galderma Research & Development Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics

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US9266848B2 (en) 2016-02-23
EP2477969A1 (en) 2012-07-25
FR2950056B1 (fr) 2011-08-26
EP2477969B1 (en) 2013-10-23
US20120226033A1 (en) 2012-09-06
ES2442772T3 (es) 2014-02-13
FR2950056A1 (fr) 2011-03-18
CA2771679A1 (en) 2011-03-24
WO2011033010A1 (en) 2011-03-24

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