[go: up one dir, main page]

AR078140A1 - Metodo para la preparacion de 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano - Google Patents

Metodo para la preparacion de 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano

Info

Publication number
AR078140A1
AR078140A1 ARP100102321A ARP100102321A AR078140A1 AR 078140 A1 AR078140 A1 AR 078140A1 AR P100102321 A ARP100102321 A AR P100102321A AR P100102321 A ARP100102321 A AR P100102321A AR 078140 A1 AR078140 A1 AR 078140A1
Authority
AR
Argentina
Prior art keywords
pentamethylcyclohexane
preparation
pentametilciclohexano
chloroacetamide
hydroxy
Prior art date
Application number
ARP100102321A
Other languages
English (en)
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of AR078140A1 publication Critical patent/AR078140A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Método para la preparacion de 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano, un intermediario en la síntesis de 1-amino-1,3,3,5,5-pentametilciclohexano (Neramexane) o una sal farmacéuticamente aceptable del mismo, que comprende la etapa (iii) hacer reaccionar 1-hidroxi-1,3,3,5,5-pentametilciclohexano con cloroacetonitrilo en presencia de un ácido, en donde 1-hidroxi-1,3,3,5,5-pentametilciclohexano se emplea en la etapa (iii) tal como se obtuvo en la reaccion de un haluro de metilmagnesio con 3,3,5,5-tetrametilciclohexanona sin haber sido sometida a una etapa de purificacion.
ARP100102321A 2009-06-29 2010-06-29 Metodo para la preparacion de 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano AR078140A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26976909P 2009-06-29 2009-06-29
EP09008462 2009-06-29

Publications (1)

Publication Number Publication Date
AR078140A1 true AR078140A1 (es) 2011-10-19

Family

ID=41314559

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102321A AR078140A1 (es) 2009-06-29 2010-06-29 Metodo para la preparacion de 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano

Country Status (7)

Country Link
US (1) US8759581B2 (es)
EP (1) EP2448911A1 (es)
JP (1) JP5749259B2 (es)
AR (1) AR078140A1 (es)
CA (1) CA2765743A1 (es)
TW (1) TW201105617A (es)
WO (1) WO2011000537A1 (es)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4084009A (en) * 1977-03-03 1978-04-11 International Flavors & Fragrances Inc. Flavoring with a hydroxy cyclohexenone derivative
DK1009732T3 (da) 1997-06-30 2003-09-22 Merz Pharma Gmbh & Co Kgaa 1-Amino-alkylcyclohexan NMDA receptor antagonister
FR2888849B1 (fr) 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
ES2379181T3 (es) 2006-02-21 2012-04-23 Hexal Ag Procedimiento para la preparación de adamantanaminas
JP5145753B2 (ja) 2006-04-20 2013-02-20 Ｊｎｃ株式会社 フルオロイソプロピル基を側鎖として有する化合物およびこれを用いた液晶組成物
JP2007308480A (ja) 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd 腸溶性固体分散体を含んでなる固形製剤
JP2007308460A (ja) * 2006-05-22 2007-11-29 Mitsubishi Chemicals Corp ２−メチル−２−アダマンタノールおよびそのマグネシウムクロリド塩の製造方法
JP2007308457A (ja) * 2006-05-22 2007-11-29 Mitsubishi Chemicals Corp ２−メチル−２−アダマンタノールおよびそのマグネシウムクロリド塩の製造方法
JP2007308463A (ja) * 2006-05-22 2007-11-29 Mitsubishi Chemicals Corp ２−メチル−２−アダマンチル（メタ）アクリレートの製造方法
JP2007308464A (ja) * 2006-05-22 2007-11-29 Mitsubishi Chemicals Corp ２−メチル−２−アダマンチル（メタ）アクリレートの製造方法
SI2202216T1 (sl) 2007-10-26 2012-10-30 Japan Tobacco Inc Spiro obročna spojina in njena uporaba za medicinske namene
JP5599878B2 (ja) 2009-06-29 2014-10-01 メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー １−アミノ−１，３，３，５，５−ペンタメチルシクロヘキサンを調製する方法
EP2448908B1 (en) 2009-06-29 2013-09-18 Merz Pharma GmbH & Co. KGaA Method of preparing neramexane
PL2448910T3 (pl) 2009-06-29 2013-10-31 Merz Pharma Gmbh & Co Kgaa Sposób wytwarzania nerameksanu
US20120123166A1 (en) 2009-06-29 2012-05-17 Merz Pharma Gmbh & Co. Kgaa Method of preparing 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane

Also Published As

Publication number Publication date
JP2012531386A (ja) 2012-12-10
JP5749259B2 (ja) 2015-07-15
EP2448911A1 (en) 2012-05-09
US20120130127A1 (en) 2012-05-24
US8759581B2 (en) 2014-06-24
CA2765743A1 (en) 2011-01-06
TW201105617A (en) 2011-02-16
WO2011000537A1 (en) 2011-01-06

Similar Documents

Publication Publication Date Title
EA201171318A1 (ru) Улучшение улавливания углерода при ферментации
JP2010090366A5 (es)
MY180098A (en) Novel process for preparing silicas
EA201491289A1 (ru) Способ получения гексаметилендиамина из 5-гидроксиметилфурфурола
EA201400045A1 (ru) Способ получения валеролактона из левулиновой кислоты
AR082569A1 (es) Produccion de alcoholes
MX2013011257A (es) Proceso para la preparacion de dronedarona por n-butilacion.
UY33325A (es) Purificación mediante adsorción de colorante caramelo
CL2011000296A1 (es) Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados.
NZ601040A (en) Method of producing acrylic and methacrylic acid
PT2462098E (pt) Processos para a preparação de derivados de ácido 1-(2- halobifenil-4-il)-ciclopropanocarboxílico
CO6602116A2 (es) Procedimiento de síntesos de la ferroquina por aminaci{on reductora convergente
MY155284A (en) Process for the preparation of ajoene
AR109248A1 (es) Procedimiento para la preparación de 4-fenilbutirato y sus usos
UA106988C2 (uk) Спосіб одержання 1-бензил-3-гідроксиметил-1h-індазолу і його похідних та необхідні проміжні сполуки магнію
UY32195A (es) Proceso para la preparación benzonorborenenos
CL2012000270A1 (es) Procedimiento de preparacion de ivabradina y de sus sales de adicion por formacion del anillo benzoacepino; y los compuestos intermediarios considerados en el procedimiento.
AR078140A1 (es) Metodo para la preparacion de 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano
AR078137A1 (es) Metodo para la preparacion de neramexane
IN2014DN03469A (es)
ES2459865B1 (es) Procedimiento de producción de aditivos oxigenados a partir de glicerina cruda
WO2014133291A9 (ko) (2rs)-아미노-(3s)-히드록시-부티르산 또는 이의 유도체의 제조방법
ATE548372T1 (de) Sorbitumwandlungsverfahren
AR078136A1 (es) Metodo para la preparacion de neramexane
EA201692281A8 (ru) Способ синтеза первичных изогексидаминов

Legal Events

Date Code Title Description
FB Suspension of granting procedure