AR077922A1 - Vitamina d3 y sus analogos para tratar la alopecia - Google Patents
Vitamina d3 y sus analogos para tratar la alopeciaInfo
- Publication number
- AR077922A1 AR077922A1 ARP100102995A ARP100102995A AR077922A1 AR 077922 A1 AR077922 A1 AR 077922A1 AR P100102995 A ARP100102995 A AR P100102995A AR P100102995 A ARP100102995 A AR P100102995A AR 077922 A1 AR077922 A1 AR 077922A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydroxyl
- halogen
- hydrogen
- alkoxy
- Prior art date
Links
- 201000004384 Alopecia Diseases 0.000 title abstract 2
- 231100000360 alopecia Toxicity 0.000 title abstract 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 17
- 150000002367 halogens Chemical class 0.000 abstract 13
- 229910052736 halogen Inorganic materials 0.000 abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 abstract 11
- 239000001257 hydrogen Substances 0.000 abstract 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 8
- -1 vitamin D compound Chemical class 0.000 abstract 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 6
- 229930003316 Vitamin D Natural products 0.000 abstract 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 6
- 239000011710 vitamin D Substances 0.000 abstract 6
- 235000019166 vitamin D Nutrition 0.000 abstract 6
- 229940046008 vitamin d Drugs 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 229960005084 calcitriol Drugs 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 2
- 208000022605 chemotherapy-induced alopecia Diseases 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 2
- 239000011647 vitamin D3 Substances 0.000 abstract 2
- 229940021056 vitamin d3 Drugs 0.000 abstract 2
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 210000002615 epidermis Anatomy 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 210000002510 keratinocyte Anatomy 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Métodos y composiciones farmacéuticas para prevenir o tratar la alopecia, tal como la alopecia inducida por quimioterapia (CIA). Las composiciones farmacéuticas que comprenden una cantidad eficaz de un compuesto de vitamina D en una formulacion que permite administrar por vía topica el compuesto de vitamina D en la capa epidérmica, pero que también permite evitar sustancialmente la capa dérmica. En los pacientes sometidos a quimioterapia. Estas composiciones farmacéuticas pueden administrarse antes de la medicacion quimioterapéutica o de manera concurrente con ella. Reivindicacion 2: El método de la reivindicacion 1, caracterizado porque la composicion farmacéutica comprende aproximadamente 40% (p/p) de propilenglicol y aproximadamente 60% (p/p) de etanol absoluto anhidro (de grado 200, U.S.); o aproximadamente 30% (p/p) de propilenglicol, aproximadamente 10% (p/p) de etoxidiglicol o de transcutol y aproximadamente 60% (p/p) de etanol absoluto anhidro (de grado 200, U.S.). Reivindicacion 3: El método de la reivindicacion 1, caracterizado porque el compuesto de vitamina D está representado por la formula (1), donde cada uno de a y b es independientemente un enlace simple o doble; X es -CH2 cuando a es un enlace doble, o X es hidrogeno o un alquilo sustituido con hidroxilo cuando a es un enlace simple; R1 es hidrogeno, hidroxilo, alcoxilo, tri-alquil sililo o alquilo, opcionalmente sustituido con entre una y tres unidades de halogeno, hidroxilo, ciano o -NR'R''; R2 es hidrogeno, hidroxilo, -O-trialquil sililo, o alquilo, alcoxilo o alquenilo, opcionalmente sustituido con entre una y tres unidades de halogeno, hidroxilo, ciano o -NR'R''; R3 está ausente cuando b es un enlace doble o R3 es hidrogeno, hidroxilo o alquilo, o R3 y R1, junto con los átomos de carbono a los que están unidos, pueden estar unidos para formar un anillo carbocíclico de 5 - 7 miembros cuando b es un enlace simple; R4 esta ausente cuando b es un enlace doble o R4 es hidrogeno, halogeno o hidroxilo cuando b es un enlace simple; R5 está ausente cuando a es un enlace doble o R5 es hidrogeno, halogeno o hidroxilo cuando a es un enlace simple; R6 es alquilo, alquenilo, alquinilo, cicloalquilo, heterociclicilo, alquil-O-alquilo, alquil-CO2-alquilo opcionalmente sustituido con entre una y cinco unidades de hidroxilo, oxo, halogeno, alcoxilo, arilo, heteroarilo, ciano, nitro o -NR'R''; R7 es alquilo opcionalmente sustituido con entre una y tres unidades de hidroxilo, halogeno, alcoxilo, arilo, heteroarilo, ciano, nitro o -NR'R''; y cada uno de R' y R'' es independientemente hidrogeno, hidroxilo, halogeno, alquilo o alcoxilo; y sales farmacéuticamente aceptables de éste. Reivindicacion 4: El método de la reivindicacion 1, caracterizado porque el compuesto de vitamina D está representado por la formula (2), donde c es un enlace simple o doble; R1a es hidrogeno, tri-alquil sililo o alquilo, opcionalmente sustituido con entre una y tres unidades de halogeno, hidroxilo, ciano o -NR'R''; R2a es hidrogeno, hidroxilo, -O-trialquil sililo, o alquilo, alcoxilo o alquenilo, opcionalmente sustituido con entre una y tres unidades de halogeno, hidroxilo, ciano o -NR'R''; R3a, R4a están ausentes cuando c es un enlace doble, o cada uno de ellos es independientemente hidrogeno, hidroxilo, halogeno, alcoxilo o alquilo opcionalmente sustituido con entre una y tres unidades de hidroxilo o halogeno cuando c es un enlace simple; cada uno de R3b, R4b, R5a, R6a, R7a y R8a es independientemente hidrogeno, hidroxilo, halogeno, alcoxilo o alquilo opcionalmente sustituido con entre una y tres unidades de hidroxilo o halogeno, o dos cualesquiera de R6a, R7a y R8a pueden estar unidos para formar un anillo carbocíclico de 3 - 7 miembros; y sales farmacéuticamente aceptables de éste. Reivindicacion 5: El método de la reivindicacion 1, caracterizado porque el compuesto de vitamina D es la 1,25-dihidroxivitamina D3, el 1,25-dihidroxi-16-en-23-in-colecalciferol, el 1,25-dihidroxI-16-en-in-colecalciferol, la 1a-hidroxivitamina D3, la 1a,24-dihidroxivitamina D3 o MC 903. Reivindicacion 7: El método de la reivindicacion 1, caracterizado porque el compuesto de vitamina D presenta un perfil de regulacion génica similar o idéntico al de una cantidad equivalente de calcitriol en queratinocitos normales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23417809P | 2009-08-14 | 2009-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077922A1 true AR077922A1 (es) | 2011-10-05 |
Family
ID=43586756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102995A AR077922A1 (es) | 2009-08-14 | 2010-08-13 | Vitamina d3 y sus analogos para tratar la alopecia |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9901637B2 (es) |
| EP (2) | EP2464357B1 (es) |
| JP (2) | JP5978130B2 (es) |
| KR (2) | KR101791828B1 (es) |
| CN (3) | CN102655869B (es) |
| AR (1) | AR077922A1 (es) |
| AU (3) | AU2010282731C1 (es) |
| BR (1) | BR112012003372A2 (es) |
| CA (1) | CA2770683C (es) |
| EA (1) | EA201270226A1 (es) |
| ES (1) | ES2742750T3 (es) |
| IL (1) | IL218043B (es) |
| IN (1) | IN2012DN02137A (es) |
| MX (2) | MX338746B (es) |
| SG (2) | SG178382A1 (es) |
| TW (2) | TW201733593A (es) |
| WO (1) | WO2011019617A2 (es) |
| ZA (2) | ZA201702812B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107019795A (zh) * | 2009-01-27 | 2017-08-08 | 博格有限责任公司 | 用于减轻与化疗有关的副作用的维生素d3化合物 |
| CN102655869B (zh) * | 2009-08-14 | 2016-08-10 | 博格有限责任公司 | 用于治疗脱发的维生素d3及其类似物 |
| JP5537352B2 (ja) * | 2010-09-09 | 2014-07-02 | 花王株式会社 | 毛成長抑制剤 |
| WO2012033162A1 (ja) * | 2010-09-09 | 2012-03-15 | 花王株式会社 | 毛成長制御方法、毛成長制御剤の評価又は選択方法、及び毛成長抑制剤 |
| JP5654808B2 (ja) * | 2010-09-09 | 2015-01-14 | 花王株式会社 | 毛成長制御剤の評価又は選択方法 |
| FR2996128B1 (fr) * | 2012-09-28 | 2015-01-02 | Inneov Lab | Utilisation d'une association de taurine ou un de ses derives, et d'extrait de raisins pour ameliorer la qualite des ongles. |
| JP6300897B2 (ja) * | 2013-03-15 | 2018-03-28 | マース インコーポレーテッドＭａｒｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 特発性嘔吐を予防、低減、緩和または治療するための組成物および方法 |
| KR20160013201A (ko) * | 2013-05-29 | 2016-02-03 | 버그 엘엘씨 | 비타민 d를 이용한 화학요법 유발 탈모증의 예방 또는 완화 |
| WO2017147420A1 (en) * | 2016-02-25 | 2017-08-31 | The University Of Florida Research Foundation, Inc. | Methods and compositions with vitamin d compounds for treatment of cystic fibrosis and respiratory disorders |
| CN105842459A (zh) * | 2016-03-24 | 2016-08-10 | 泰州海路生物技术有限公司 | 快速定量检测粪便钙卫蛋白的免疫层析试剂盒 |
| AU2017278257B2 (en) * | 2016-06-05 | 2024-04-18 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin D |
| US10500217B2 (en) | 2018-04-30 | 2019-12-10 | Leslie Ray Matthews, M.D., Llc | Vitamin D3, heat shock proteins, and glutathione for the treatment of chronic inflammation and chronic diseases |
| EP3969005A4 (en) * | 2019-05-17 | 2023-10-04 | The Trustees of The University of Pennsylvania | Methods and compositions for treating obesity and/or skin disorders |
| CN110604098B (zh) * | 2019-09-23 | 2021-09-07 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 一种类风湿关节炎合并间质性肺病动物模型的构建方法 |
| CA3260184A1 (en) | 2022-07-01 | 2024-01-04 | Jjr&D, Llc | METHOD FOR THE PREVENTION AND TREATMENT OF CHEMOTHERAPY-INDUCED ALOPECIA |
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| US4336193A (en) | 1980-08-04 | 1982-06-22 | Wisconsin Alumni Research Foundation | Process for preparing vitamin D-lactones |
| US4305880A (en) | 1980-09-22 | 1981-12-15 | Wisconsin Alumni Research Foundation | Process for preparing 24-fluoro-25-hydroxycholecalciferol |
| US4367177A (en) | 1981-04-15 | 1983-01-04 | Wisconsin Alumni Research Foundation | Process for preparing 23,25-dihydroxyvitamin D3 |
| US4279826A (en) | 1980-09-22 | 1981-07-21 | Wisconsin Alumni Research Foundation | 23,25-Dihydroxyvitamin D3 |
| US4307025A (en) | 1981-02-17 | 1981-12-22 | Wisconsin Alumni Research Foundation | 1α, 25-dihydroxy-2β-fluorovitamin D3 |
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| US4360471A (en) | 1981-12-11 | 1982-11-23 | Wisconsin Alumni Research Foundation | 23-Dehydro-25-hydroxyvitamin D3 |
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| US4428946A (en) | 1982-07-26 | 1984-01-31 | Wisconsin Alumni Research Foundation | Method of preventing milk fever in dairy cattle |
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