AR077823A1 - Proceso para preparar compuestos de benzimidazol sustituidos con 2-arilamino o heteroarilamino - Google Patents
Proceso para preparar compuestos de benzimidazol sustituidos con 2-arilamino o heteroarilaminoInfo
- Publication number
- AR077823A1 AR077823A1 ARP100102911A AR077823A1 AR 077823 A1 AR077823 A1 AR 077823A1 AR P100102911 A ARP100102911 A AR P100102911A AR 077823 A1 AR077823 A1 AR 077823A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluorine atoms
- optionally substituted
- alkoxy
- pyridyl
- heteroarilamino
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate Chemical compound [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos obtenidos son utiles para terapia. Reivindicacion 1: Un proceso para preparar un compuesto de formula (1) en la que: R1, R2, R3 y R4 son cada uno independientemente H, halogeno, hidroxilo, alquilo C1-6 opcionalmente sustituido con hasta tres átomos de fluor, alcoxi C1-6 opcionalmente sustituido con hasta tres átomos de fluor, (alcoxi C1-6)carbonilo, (alcoxi C1-4)carbonilamido, amino o carboxi; y Ar es fenilo, naftilo, 3-piridilo, 4-piridilo o tienilo, en el que el fenilo y el naftilo están opcionalmente sustituidos independientemente con halogeno, alquilo C1-6 opcionalmente sustituido con hasta tres átomos de fluor, o alcoxi C1-6 opcionalmente sustituido con hasta tres átomos de fluor, y en el que el 3-piridilo, el 4-piridilo y el tienilo están opcionalmente sustituidos independientemente con alquilo C1-C6 opcionalmente sustituido con hasta tres átomos de fluor, o alcoxi C1-6 opcionalmente sustituido con hasta tres átomos de fluor; o su sal de adicion de ácidos; que comprende hacer reaccionar un compuesto de formula (2) en la que R1, R2, R3 y R4 son como se definio anteriormente, con un compuesto de formula: Ar-NH2 o su sal de adicion de ácidos, en la que Ar es como se definio anteriormente, opcionalmente en presencia de una base adecuada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23293209P | 2009-08-11 | 2009-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077823A1 true AR077823A1 (es) | 2011-09-28 |
Family
ID=42752011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102911 AR077823A1 (es) | 2009-08-11 | 2010-08-09 | Proceso para preparar compuestos de benzimidazol sustituidos con 2-arilamino o heteroarilamino |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR077823A1 (es) |
| TW (1) | TW201111350A (es) |
| WO (1) | WO2011019781A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106536520B (zh) * | 2014-06-27 | 2020-08-14 | 诺格拉制药有限公司 | 芳基受体调制剂及其制备和使用方法 |
| EP3015469B1 (en) | 2014-10-30 | 2018-12-19 | Idemitsu Kosan Co., Ltd. | 5-(benzimidazol-2-yl)benzimidazo[1,2-a]benzimidazoles for electronic applications |
| KR101850282B1 (ko) * | 2014-11-26 | 2018-05-31 | 한국과학기술연구원 | 단백질 키나아제 저해제로 유용한 헤테로아릴아민 유도체 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
| MXPA06007110A (es) * | 2003-12-18 | 2006-08-23 | Tibotec Pharm Ltd | Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio. |
-
2010
- 2010-08-09 AR ARP100102911 patent/AR077823A1/es unknown
- 2010-08-10 TW TW99126553A patent/TW201111350A/zh unknown
- 2010-08-11 WO PCT/US2010/045110 patent/WO2011019781A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011019781A1 (en) | 2011-02-17 |
| TW201111350A (en) | 2011-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |