AR077055A1 - Derivados de benzimidazol como moduladores del canal trpm8 - Google Patents
Derivados de benzimidazol como moduladores del canal trpm8Info
- Publication number
- AR077055A1 AR077055A1 ARP100102053A ARP100102053A AR077055A1 AR 077055 A1 AR077055 A1 AR 077055A1 AR P100102053 A ARP100102053 A AR P100102053A AR P100102053 A ARP100102053 A AR P100102053A AR 077055 A1 AR077055 A1 AR 077055A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- group
- heterocycloalkyl
- heteroaryl
- cycloalkyl
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 102000003610 TRPM8 Human genes 0.000 title 1
- 101150111302 Trpm8 gene Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 25
- 125000003545 alkoxy group Chemical group 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000002829 nitrogen Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describen los compuestos, composiciones y métodos para tratar diferentes enfermedades, síndromes, afecciones y trastornos que incluyen el dolor. Reivindicacion 1: Un compuesto de la formula (1) en donde a es un numero entero de 0 a 3; cada R0 se selecciona independientemente del grupo que consiste de halogeno, hidroxi, ciano, alquilo inferior, alquilo inferior fluorado, alcoxi inferior y alcoxi inferior fluorado; R2 se selecciona del grupo que consiste de hidrogeno, halogeno, hidroxi, ciano, alquilo inferior, alquilo inferior fluorado, alcoxi inferior y alcoxi inferior fluorado; R1 se selecciona del grupo que consiste de alquilo, alquilo inferior sustituido con hidroxi, alquilo inferior halogenado, cicloalquilo-(alquilo inferior) y fenilo-(alquilo inferior); alternativamente, R2 y R1 se toman juntos como en restos (2) o (3); R3 se selecciona del grupo que consiste de alquilo inferior, cicloalquilo, arilo, heteroarilo, heterocicloalquilo, cicloalquilo-(alquilo inferior), arilo-(alquilo inferior), heteroarilo-(alquilo inferior) y heterocicloalquilo-(alquilo inferior); en donde el cicloalquilo, arilo, heteroarilo o heterocicloalquilo, ya sea solo o como parte de un grupo sustituyente se sustituye opcionalmente con uno o más sustituyentes independientemente seleccionados del grupo que consiste de halogeno, alquilo inferior, alquilo inferior halogenado, alcoxi inferior, alcoxi inferior halogenado, -C(O)OH, -C(O)O-(alquilo inferior) y -C(O)NRARB; en donde RA y RB se seleccionan independientemente del grupo que consiste de hidrogeno y alquilo inferior; alternativamente RA y RB se toman juntos con el átomo de nitrogeno al cual están unidos para formar una estructura de anillo que contiene nitrogeno saturado de 5 a 6 miembros; R4 se selecciona del grupo que consiste de alquilo inferior, cicloalquilo, arilo, heteroarilo, heterocicloalquilo, cicloalquilo-(alquilo inferior), arilo-(alquilo inferior), heteroarilo-(alquilo inferior) y heterocicloalquilo-(alquilo inferior); en donde el cicloalquilo, arilo, heteroarilo o heterocicloalquilo, ya sea solo o como parte de un grupo sustituyente se sustituye opcionalmente con uno o más sustituyentes independientemente seleccionados del grupo que consiste de halogeno, alquilo inferior, alquilo inferior halogenado, alcoxi inferior, alcoxi inferior halogenado y -S-CF3; siempre y cuando R4 sea heteroarilo o heterocicloalquilo, entonces el grupo R4 está unido al N del compuesto de la formula (1) a través de un átomo de carbono; o una sal farmacéuticamente aceptable de éstos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18568609P | 2009-06-10 | 2009-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077055A1 true AR077055A1 (es) | 2011-07-27 |
Family
ID=42670634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102053A AR077055A1 (es) | 2009-06-10 | 2010-06-10 | Derivados de benzimidazol como moduladores del canal trpm8 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8242157B2 (es) |
| EP (1) | EP2440294B1 (es) |
| JP (1) | JP2012530053A (es) |
| CN (1) | CN102802731A (es) |
| AR (1) | AR077055A1 (es) |
| AU (1) | AU2010258714B2 (es) |
| CA (1) | CA2764567A1 (es) |
| RU (1) | RU2011153431A (es) |
| TW (1) | TW201103941A (es) |
| WO (1) | WO2010144680A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001098344A2 (en) * | 2000-06-16 | 2001-12-27 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| CN103354812A (zh) | 2010-12-09 | 2013-10-16 | 詹森药业有限公司 | 作为trpm8调节剂的咪唑并[1,2-a]吡啶磺酰胺 |
| WO2012098281A2 (es) | 2011-01-19 | 2012-07-26 | Universidad Miguel Hernández De Elche | Péptidos moduladores de receptores trp y sus usos |
| CN103443080B (zh) | 2011-03-16 | 2016-10-12 | 田边三菱制药株式会社 | 具有trpm8拮抗活性的磺酰胺化合物 |
| MY157429A (en) * | 2011-06-24 | 2016-06-15 | Amgen Inc | Trpm8 antagonists and their use in treatments |
| EP2896613B1 (en) * | 2012-09-14 | 2018-03-21 | Mitsubishi Tanabe Pharma Corporation | Sulfonamide compound |
| JP5985453B2 (ja) * | 2012-09-14 | 2016-09-06 | 田辺三菱製薬株式会社 | 医薬組成物 |
| WO2014143768A1 (en) | 2013-03-15 | 2014-09-18 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| ES2635560T3 (es) | 2013-07-08 | 2017-10-04 | Incyte Holdings Corporation | Heterociclos tricíclicos como inhibidores de la proteína NET |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| ES2942723T3 (es) | 2014-04-23 | 2023-06-06 | Incyte Holdings Corp | 1H-pirrolo[2,3-C]piridin-7(6H)-onas y pirazolo[3,4-C]piridin-7(6H)-onas como inhibidores de proteínas BET |
| ES2855225T3 (es) | 2014-09-15 | 2021-09-23 | Incyte Corp | Heterociclos tricíclicos para su uso como inhibidores de proteínas BET |
| WO2017075377A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
| CN114748624A (zh) | 2016-06-13 | 2022-07-15 | 田边三菱制药株式会社 | 用于治疗或预防血管舒缩症状的组合物 |
| KR20250163425A (ko) | 2016-06-20 | 2025-11-20 | 인사이트 코포레이션 | Bet 저해제의 결정질 고체 형태 |
| WO2020038387A1 (zh) * | 2018-08-24 | 2020-02-27 | 杭州阿诺生物医药科技有限公司 | 高活性sting蛋白激动剂 |
| CA3110474C (en) * | 2018-08-29 | 2024-04-23 | Adlai Nortye Biopharma Co., Ltd. | Highly active sting protein agonist compound |
| WO2020132566A1 (en) * | 2018-12-21 | 2020-06-25 | Nimbus Titan, Inc. | Sting pyrazole agonists and uses thereof |
| WO2020151682A1 (zh) * | 2019-01-23 | 2020-07-30 | 成都先导药物开发股份有限公司 | 一种大环类免疫调节剂 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007134107A2 (en) * | 2006-05-10 | 2007-11-22 | Janssen Pharmaceutica N.V. | Cold menthol receptor-1 antagonists |
| US20080287398A1 (en) * | 2007-05-02 | 2008-11-20 | Colburn Raymond W | Cold menthol receptor-1 antagonists |
| PA8790401A1 (es) | 2007-07-18 | 2009-03-31 | Janssen Pharmaceutica Nv | Sulfonamidas como moduladores de trpm8 |
-
2010
- 2010-06-09 TW TW099118640A patent/TW201103941A/zh unknown
- 2010-06-10 EP EP10724662.1A patent/EP2440294B1/en active Active
- 2010-06-10 RU RU2011153431/04A patent/RU2011153431A/ru not_active Application Discontinuation
- 2010-06-10 JP JP2012515130A patent/JP2012530053A/ja not_active Withdrawn
- 2010-06-10 CN CN2010800360350A patent/CN102802731A/zh active Pending
- 2010-06-10 AU AU2010258714A patent/AU2010258714B2/en not_active Ceased
- 2010-06-10 AR ARP100102053A patent/AR077055A1/es unknown
- 2010-06-10 WO PCT/US2010/038136 patent/WO2010144680A1/en not_active Ceased
- 2010-06-10 US US12/797,743 patent/US8242157B2/en not_active Expired - Fee Related
- 2010-06-10 CA CA2764567A patent/CA2764567A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2440294B1 (en) | 2013-07-24 |
| US8242157B2 (en) | 2012-08-14 |
| WO2010144680A1 (en) | 2010-12-16 |
| TW201103941A (en) | 2011-02-01 |
| AU2010258714B2 (en) | 2014-09-11 |
| EP2440294A1 (en) | 2012-04-18 |
| US20110003801A1 (en) | 2011-01-06 |
| AU2010258714A1 (en) | 2012-01-12 |
| RU2011153431A (ru) | 2013-07-20 |
| JP2012530053A (ja) | 2012-11-29 |
| HK1169070A1 (en) | 2013-01-18 |
| CA2764567A1 (en) | 2010-12-16 |
| CN102802731A (zh) | 2012-11-28 |
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