AR077021A1 - Formas de dosificacion farmaceutica para administracion oral de un inhibidor de la familia bcl 2 - Google Patents
Formas de dosificacion farmaceutica para administracion oral de un inhibidor de la familia bcl 2Info
- Publication number
- AR077021A1 AR077021A1 ARP100102011A ARP100102011A AR077021A1 AR 077021 A1 AR077021 A1 AR 077021A1 AR P100102011 A ARP100102011 A AR P100102011A AR P100102011 A ARP100102011 A AR P100102011A AR 077021 A1 AR077021 A1 AR 077021A1
- Authority
- AR
- Argentina
- Prior art keywords
- dosage form
- pharmaceutically acceptable
- solubilizer
- pharmaceutical dosage
- methyl
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title abstract 9
- 102000051485 Bcl-2 family Human genes 0.000 title 1
- 108700038897 Bcl-2 family Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 6
- -1 (trifluoromethyl) sulfonyl Chemical group 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 125000000129 anionic group Chemical group 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920005862 polyol Polymers 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 239000007962 solid dispersion Substances 0.000 abstract 2
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 abstract 1
- 125000005599 alkyl carboxylate group Chemical group 0.000 abstract 1
- 150000008051 alkyl sulfates Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una forma de dosificacion farmacéutica que comprende un producto de dispersion solida que comprende N-(4-(4-((2-(4-clorofenil)-5,5-dimetil-1-ciclohex-1-en-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil) propil)amino)-3-((trifluorometil)sulfonil)bencenosulfonamida o una sal, hidrato o solvato de la misma, al menos un polímero farmacéuticamente aceptable, y al menos un solubilizante farmacéuticamente aceptable. La presente además está dirigida a procesos para preparar la forma de dosificacion farmacéutica y para usar la forma de dosificacion para tratar trastornos proliferativos. Reivindicacion 3: La forma de dosificacion de la reivindicacion 2, caracterizada porque el solubilizante no ionico farmacéuticamente aceptable se selecciona del grupo que consiste en ésteres de poliol ácido graso, ésteres de poliol ácido graso polialcoxilados, éteres de alcohol graso polialcoxilados, compuestos de tocoferilo y mezclas de dos o más de los mismos, y en donde el solubilizante anionico farmacéuticamente aceptable se selecciona del grupo que consiste en sulfatos de alquilo, alquilcarboxilatos, alquilbenzol sulfatos y sulfonatos de alcano secundarios. Reivindicacion 6: La forma de dosificacion de la reivindicacion 2, caracterizada porque comprende al menos un solubilizante no ionico farmacéuticamente aceptable y al menos un solubilizante anionico farmacéuticamente aceptable. Reivindicacion 9: La forma de dosificacion de la reivindicacion 8, caracterizada porque dicho solvente no volátil es propilenglicol. Reivindicacion 17: La forma de dosificacion de la reivindicacion 1, caracterizada porque comprende menos de 0,9% en peso de productos de descomposicion con sulfoxido del ingrediente activo, en relacion al peso del ingrediente activo. Reivindicacion 18: La forma de dosificacion de la reivindicacion 1, caracterizada porque el producto de dispersion solida es una mezcla procesada por fusion, solidificada. Reivindicacion 20: El método de la reivindicacion 19, caracterizado porque el trastorno proliferativo se selecciona a partir de tumores y cánceres.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18513009P | 2009-06-08 | 2009-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077021A1 true AR077021A1 (es) | 2011-07-27 |
Family
ID=43063251
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102011A AR077021A1 (es) | 2009-06-08 | 2010-06-08 | Formas de dosificacion farmaceutica para administracion oral de un inhibidor de la familia bcl 2 |
| ARP170102786A AR109816A2 (es) | 2009-06-08 | 2017-10-05 | Forma de dosificación farmacéutica para administración oral de un inhibidor de la familia bcl-2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170102786A AR109816A2 (es) | 2009-06-08 | 2017-10-05 | Forma de dosificación farmacéutica para administración oral de un inhibidor de la familia bcl-2 |
Country Status (37)
| Country | Link |
|---|---|
| US (6) | US9642796B2 (es) |
| EP (3) | EP2440177B1 (es) |
| JP (2) | JP5872459B2 (es) |
| KR (2) | KR101751216B1 (es) |
| CN (2) | CN102802606A (es) |
| AR (2) | AR077021A1 (es) |
| AU (1) | AU2010258367B2 (es) |
| BR (2) | BRPI1012831B1 (es) |
| CA (1) | CA2763441C (es) |
| CL (1) | CL2011003054A1 (es) |
| CO (1) | CO6480964A2 (es) |
| CR (1) | CR20170037A (es) |
| CY (1) | CY1119663T1 (es) |
| DK (2) | DK2440177T3 (es) |
| DO (2) | DOP2011000375A (es) |
| EC (1) | ECSP12011580A (es) |
| ES (2) | ES2651307T3 (es) |
| HR (2) | HRP20151342T1 (es) |
| HU (2) | HUE025638T2 (es) |
| IL (2) | IL216494A (es) |
| LT (1) | LT2982366T (es) |
| MX (1) | MX2011013164A (es) |
| MY (1) | MY159824A (es) |
| NO (1) | NO2982366T3 (es) |
| NZ (1) | NZ597241A (es) |
| PE (2) | PE20121084A1 (es) |
| PL (2) | PL2982366T3 (es) |
| PT (2) | PT2440177E (es) |
| RU (2) | RU2568599C2 (es) |
| SG (1) | SG176264A1 (es) |
| SI (2) | SI2440177T1 (es) |
| SM (1) | SMT201500317B (es) |
| TW (2) | TWI471321B (es) |
| UA (1) | UA104471C2 (es) |
| UY (1) | UY32695A (es) |
| WO (1) | WO2010143074A2 (es) |
| ZA (1) | ZA201108853B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI471321B (zh) | 2009-06-08 | 2015-02-01 | 亞培公司 | Ｂｃｌ－２族群抑制劑之口服醫藥劑型 |
| US8557995B2 (en) | 2010-06-09 | 2013-10-15 | Abbvie Inc. | Solid dispersions containing kinase inhibitors |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| IL225340A (en) | 2010-10-29 | 2017-05-29 | Abbvie Inc | Solid dispersions containing cell mortality |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| SI2643322T1 (en) | 2010-11-23 | 2018-01-31 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| US20120129853A1 (en) | 2010-11-23 | 2012-05-24 | Abbott Laboratories | Methods of treatment using selective bcl-2 inhibitors |
| KR102191562B1 (ko) * | 2012-11-07 | 2020-12-15 | 에스케이바이오팜 주식회사 | 난용성 약물의 고체분산체 및 이의 제조방법 |
| US20160022708A1 (en) * | 2013-03-14 | 2016-01-28 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2015051252A1 (en) * | 2013-10-03 | 2015-04-09 | Duke University | Compositions and methods for treating cancer with jak2 activity |
| WO2015138615A2 (en) * | 2014-03-12 | 2015-09-17 | Irm Llc | Specific sites for modifying antibodies to make immunoconjugates |
| CN106456556A (zh) * | 2014-06-18 | 2017-02-22 | 豪夫迈·罗氏有限公司 | 包含非离子性表面活性剂的新型药物组合物 |
| CN105616419A (zh) * | 2014-11-07 | 2016-06-01 | 江苏豪森药业集团有限公司 | 含有细胞周期蛋白抑制剂固体分散体的药物组合物及其制备方法 |
| CN108367005B (zh) | 2016-02-29 | 2022-01-07 | 豪夫迈·罗氏有限公司 | 包含酪氨酸蛋白激酶抑制剂的剂型组合物 |
| JOP20190191A1 (ar) | 2017-02-22 | 2019-08-08 | Astrazeneca Ab | وحدات شجرية علاجية |
| US11872237B2 (en) * | 2018-12-28 | 2024-01-16 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition and preparation method thereof |
| MX2022005375A (es) | 2019-11-05 | 2022-10-07 | Abbvie Inc | Regímenes de dosificación para usar en el tratamiento de la mielofibrosis y trastornos relacionados con neoplasias mieloproliferativas (nmp) con navitoclax. |
| IL295803A (en) * | 2020-02-24 | 2022-10-01 | Newave Pharmaceutical Inc | Hot melt extruded solid dispersions containing a bcl2 inhibitor |
| WO2022111558A1 (en) * | 2020-11-25 | 2022-06-02 | Ascentage Pharma (Suzhou) Co., Ltd. | Solid dispersion, pharmaceutical preparations, preparation method, and application thereof |
| US20240091183A1 (en) * | 2021-01-08 | 2024-03-21 | Syros Pharmaceuticals, Inc. | Treatment regimens with fixed doses of tamibarotene |
| CN113520995B (zh) * | 2021-08-16 | 2023-03-10 | 海南鑫开源医药科技有限公司 | 一种离子敏感型眼用原位凝胶、其制备方法及应用 |
| TW202345857A (zh) * | 2022-03-08 | 2023-12-01 | 美商昂科斯克塞爾醫療有限責任公司 | 他波司他之穩定調配物 |
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