AR076692A1 - Piperidinas sustituidas - Google Patents
Piperidinas sustituidasInfo
- Publication number
- AR076692A1 AR076692A1 ARP100101749A ARP100101749A AR076692A1 AR 076692 A1 AR076692 A1 AR 076692A1 AR P100101749 A ARP100101749 A AR P100101749A AR P100101749 A ARP100101749 A AR P100101749A AR 076692 A1 AR076692 A1 AR 076692A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- phenyl
- alkoxy
- group
- Prior art date
Links
- -1 cyano, hydroxyl Chemical group 0.000 abstract 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 11
- 125000001424 substituent group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 125000005241 heteroarylamino group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006002 1,1-difluoroethyl group Chemical group 0.000 abstract 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 208000013527 cardiovascular neoplasm Diseases 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
Se refiere a piperidinas sustituidas, a procedimientos para su preparacion, al uso de las mismas para tratamiento y/o profilaxis de enfermedades y al uso de las mismas para la produccion de medicamentos para tratamiento y/o profilaxis de enfermedades, especialmente de trastornos cardiovasculares y trastornos tumorales. Reivindicacion 1: Compuesto de la formula en la que A es un átomo de oxígeno o -NR4-, en la que R4 es hidrogeno o alquilo C1-3, o R2 y R4 junto con el átomo de nitrogeno al que están unidos forman un heterociclo de 4 a 6 miembros, en la que el heterociclo puede estar sustituido con 1 a 3 sustituyentes seleccionados de forma independiente del grupo compuesto por halogeno, ciano, hidroxilo, amino, alquilo C1-4, alcoxi C1-4 y alquilamino C1-4, R1 es fenilo, donde el fenilo puede estar sustituido con 1 a 3 sustituyentes seleccionados de forma independiente del grupo constituido por halogeno, monofluorometilo, difluorometilo, trifluorometilo, 1,1- difluoroetilo, 2,2,2-trifluoroetilo, monofluorometoxi, difluorometoxi, trifluorometoxi, monofluorometilsulfanilo, difluorometilsulfanilo, trifluorometilsulfanilo, metilsulfonilo, alquilo C1-4, alcoxi C1-4 y alcoxicarbonilo C1-4, R2 es alquilo C1-6, cicloalquilo C3-6, heterociclilo de 4 a 6 miembros, fenilo o heteroarilo de 5 o 6 miembros, donde cicloalquilo, heterociclilo, fenilo y heteroarilo pueden estar sustituidos con 1 a 3 sustituyentes seleccionados de forma independiente del grupo constituido por halogeno, ciano, hidroxilo, amino, monofluorometilo, difluorometilo, trifluorometilo, monofluorometoxi, difluorometoxi, trifluorometoxi, monofluorometilsulfanilo, difluorometilsulfanilo, trifluorometilsulfanilo, alquilo C1-4, alcoxi C1-4, alquilamino C1-6 y fenilo donde fenilo puede estar sustituido don 1 a 3 sustituyentes seleccionados de forma independiente del grupo constituido por halogeno y trifluorometilo, y donde el alquilo C1-6 puede estar sustituido con un sustituyente seleccionado del grupo constituido por hidroxilo, trifluorometilo, alcoxi C1-4, alquilsulfonilo C1-4, cicloalquilo C3-6 y fenilo, en el que el cicloalquilo y el fenilo pueden estar sustituidos con 1 a 3 sustituyentes seleccionados de forma independiente del grupo compuesto por halogeno, ciano, monofluorometilo, difluorometilo, trifluorometilo, monofluorometoxi, difluorometoxi, trifluorometoxi, alquilo C1-4 y alcoxi C1-4, R3 es alquilo C1-6, alcoxi C1-6, alquilamino C1-6, cicloalquilo C3-7, heterociclilo de 4 a 7 miembros, fenilo, heteroarilo de 5 o 6 miembros, cicloalquiloxi C3-7, cicloalquilamino C3-7, heterociclilamino de 4 a 7 miembros, fenilamino o heteroarilamino de 5 o 6 miembros, donde el alquilo, el alcoxi C2-6 y el alquilamino pueden estar sustituidos con un sustituyente seleccionado del grupo constituido por halogeno, hidroxilo, amino, ciano, alcoxi C1-4, alcoxicarbonilo C1-4, cicloalquilo C3-7, heterociclilo de 4 a 6 miembros, fenilo y heteroarilo de 5 o 6 miembros, y donde cicloalquilo, heterociclilo, fenilo, heteroarilo, cicloalquiloxi, cicloalquilamino, heterociclilamino, fenilamino y heteroarilamino pueden estar sustituidos con 1 a 3 sustituyentes seleccionados de forma independiente del grupo constituido por halogeno, ciano, oxo, hidroxilo, amino, monofluorometilo, difluorometilo, trifluorometilo, monofluorometoxi, difluorometoxi, trifluorometoxi, monofluorometilsulfanilo, difluorometilsulfanilo, trifluorometilsulfanilo, hidroxicarbonilo, aminocarbonilo, alquilo C1-4, alcoxi C1-4 alquilamino C1-6, alcoxicarbonilo C1-4, alquilaminocarbonilo C1-4 y ciclopropilo, donde alquilo puede estar sustituido con un sustituyente hidroxilo, o una de sus sales, de sus solvatos o de los solvatos de sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009022896A DE102009022896A1 (de) | 2009-05-27 | 2009-05-27 | Substituierte Piperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076692A1 true AR076692A1 (es) | 2011-06-29 |
Family
ID=42543057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101749A AR076692A1 (es) | 2009-05-27 | 2010-05-20 | Piperidinas sustituidas |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20120220563A1 (es) |
| EP (1) | EP2435427A1 (es) |
| JP (1) | JP5718320B2 (es) |
| KR (1) | KR20120044289A (es) |
| CN (2) | CN104744452A (es) |
| AR (1) | AR076692A1 (es) |
| AU (1) | AU2010252345A1 (es) |
| BR (1) | BRPI1012055A2 (es) |
| CA (1) | CA2763400A1 (es) |
| CL (1) | CL2011002965A1 (es) |
| CO (1) | CO6470823A2 (es) |
| CR (1) | CR20110628A (es) |
| CU (1) | CU20110215A7 (es) |
| DE (1) | DE102009022896A1 (es) |
| DO (1) | DOP2011000364A (es) |
| EA (1) | EA201190312A1 (es) |
| EC (2) | ECSP11011483A (es) |
| GT (1) | GT201100300A (es) |
| IL (1) | IL215901A0 (es) |
| MA (1) | MA33290B1 (es) |
| MX (1) | MX2011012505A (es) |
| PE (1) | PE20120934A1 (es) |
| SG (1) | SG175753A1 (es) |
| TN (1) | TN2011000595A1 (es) |
| TW (1) | TW201109326A (es) |
| UY (2) | UY32636A (es) |
| WO (1) | WO2010136144A1 (es) |
| ZA (1) | ZA201108565B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009014484A1 (de) | 2009-03-23 | 2010-09-30 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022896A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022892A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022894A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| UA115133C2 (uk) | 2011-10-07 | 2017-09-25 | Такеда Фармасьютікал Компані Лімітед | Сполуки 1-арилкарбоніл-4-оксипіперидину, придатні для лікування нейродегенеративних захворювань |
| US10851108B2 (en) | 2016-04-20 | 2020-12-01 | Bristol-Myers Squibb Company | Substituted bicyclic heterocyclic compounds |
| US10723723B2 (en) | 2016-11-03 | 2020-07-28 | Bristol-Myers Squibb Company | Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors |
| DK3630752T3 (da) | 2017-06-01 | 2021-08-09 | Bristol Myers Squibb Co | Substituerede nitrogenholdige forbindelser |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5767144A (en) | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
| WO1997036873A1 (en) | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| US6403612B2 (en) | 2000-01-31 | 2002-06-11 | Merck & Co., Inc. | Thrombin receptor antagonists |
| UA75980C2 (en) | 2001-10-15 | 2006-06-15 | Janssen Pharmaceutica Nv | Substituted 4-pheny1-4-[1h-imidazol-2-yl] piperidine derivative for reducing ischaemic damages |
| EP1480957A1 (en) * | 2002-03-01 | 2004-12-01 | Smithkline Beecham Corporation | Hppars activators |
| UA95769C2 (ru) * | 2004-06-24 | 2011-09-12 | Инсайт Корпорейшн | N-замещенные пиперидины и их применение в качестве фармацевтических препаратов |
| CA2570637A1 (en) | 2004-06-24 | 2006-02-02 | Wenqing Yao | N-substituted piperidines and their use as pharmaceuticals |
| JP2008504279A (ja) | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| KR20070024639A (ko) | 2004-06-24 | 2007-03-02 | 인사이트 산 디에고 인코포레이티드 | 아미도 화합물 및 약제로서의 이의 용도 |
| TW200626156A (en) | 2004-08-10 | 2006-08-01 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| JP2007008913A (ja) * | 2004-09-17 | 2007-01-18 | Tanabe Seiyaku Co Ltd | ピペリジン化合物およびその製法 |
| DE102004045796A1 (de) | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
| DE102004061750A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Heteroaryl-substituierte Pyrazoline |
| JP2009508963A (ja) | 2005-09-21 | 2009-03-05 | インサイト・コーポレイション | アミド化合物および医薬組成物としてのその使用 |
| US20070197530A1 (en) | 2006-01-31 | 2007-08-23 | Yun-Long Li | Amido compounds and their use as pharmaceuticals |
| WO2007101270A1 (en) | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| EP2013163A1 (en) | 2006-05-01 | 2009-01-14 | Incyte Corporation | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 |
| CN101932577B (zh) | 2007-11-30 | 2013-07-17 | 拜耳知识产权有限责任公司 | 杂芳基取代的哌啶 |
| DE102009014484A1 (de) * | 2009-03-23 | 2010-09-30 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022896A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022894A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022897A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
-
2009
- 2009-05-27 DE DE102009022896A patent/DE102009022896A1/de not_active Withdrawn
-
2010
- 2010-05-13 UY UY0001032636A patent/UY32636A/es not_active Application Discontinuation
- 2010-05-13 UY UY0001032638A patent/UY32638A/es not_active Application Discontinuation
- 2010-05-19 MX MX2011012505A patent/MX2011012505A/es active IP Right Grant
- 2010-05-19 EA EA201190312A patent/EA201190312A1/ru unknown
- 2010-05-19 CN CN201510061018.7A patent/CN104744452A/zh active Pending
- 2010-05-19 EP EP10724697A patent/EP2435427A1/de not_active Withdrawn
- 2010-05-19 AU AU2010252345A patent/AU2010252345A1/en not_active Abandoned
- 2010-05-19 CA CA2763400A patent/CA2763400A1/en not_active Abandoned
- 2010-05-19 WO PCT/EP2010/003059 patent/WO2010136144A1/de not_active Ceased
- 2010-05-19 MA MA34375A patent/MA33290B1/fr unknown
- 2010-05-19 SG SG2011076833A patent/SG175753A1/en unknown
- 2010-05-19 KR KR1020117028157A patent/KR20120044289A/ko not_active Withdrawn
- 2010-05-19 CN CN201080036227.1A patent/CN102596944B/zh not_active Expired - Fee Related
- 2010-05-19 PE PE2011002010A patent/PE20120934A1/es not_active Application Discontinuation
- 2010-05-19 BR BRPI1012055A patent/BRPI1012055A2/pt not_active IP Right Cessation
- 2010-05-19 JP JP2012512238A patent/JP5718320B2/ja not_active Expired - Fee Related
- 2010-05-19 US US13/321,966 patent/US20120220563A1/en not_active Abandoned
- 2010-05-20 AR ARP100101749A patent/AR076692A1/es not_active Application Discontinuation
- 2010-05-26 TW TW099116745A patent/TW201109326A/zh unknown
- 2010-05-27 US US12/788,529 patent/US8084469B2/en not_active Expired - Fee Related
-
2011
- 2011-10-25 IL IL215901A patent/IL215901A0/en unknown
- 2011-11-22 ZA ZA2011/08565A patent/ZA201108565B/en unknown
- 2011-11-24 CR CR20110628A patent/CR20110628A/es unknown
- 2011-11-24 DO DO2011000364A patent/DOP2011000364A/es unknown
- 2011-11-24 CO CO11161612A patent/CO6470823A2/es not_active Application Discontinuation
- 2011-11-24 CL CL2011002965A patent/CL2011002965A1/es unknown
- 2011-11-24 TN TNP2011000595A patent/TN2011000595A1/en unknown
- 2011-11-25 EC EC2011011483A patent/ECSP11011483A/es unknown
- 2011-11-25 GT GT201100300A patent/GT201100300A/es unknown
- 2011-11-25 EC EC2011011482A patent/ECSP11011482A/es unknown
- 2011-11-25 CU CU20110215A patent/CU20110215A7/es unknown
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