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AR076427A1 - TRIAZOL COMPOUNDS THAT CARRY A SUBSTITUTE OF SULFUR II - Google Patents

TRIAZOL COMPOUNDS THAT CARRY A SUBSTITUTE OF SULFUR II

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Publication number
AR076427A1
AR076427A1 ARP100101397A ARP100101397A AR076427A1 AR 076427 A1 AR076427 A1 AR 076427A1 AR P100101397 A ARP100101397 A AR P100101397A AR P100101397 A ARP100101397 A AR P100101397A AR 076427 A1 AR076427 A1 AR 076427A1
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AR
Argentina
Prior art keywords
alkyl
phenyl
hydrogen
alkoxy
haloalkyl
Prior art date
Application number
ARP100101397A
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Spanish (es)
Original Assignee
Basf Se
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Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of AR076427A1 publication Critical patent/AR076427A1/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Composiciones agrícolas que los contienen, su uso como fungicidas y compuestos intermediarios usados en los métodos para producirlos. Composiciones farmacéuticas y su uso como antiviral, antimicotico y anticancerígeno. Reivindicacion 1: Compuestos de triazol caracterizados porque tienen las formulas 1 y 2: en donde L1 y L4, independientemente uno del otro, se seleccionan de hidrogeno, bromo, yodo, C1-10-alquilo, C1-10-haloalquilo, C1-10-alcoxi y C1-10-haloalcoxi; L2 y L3, independientemente uno del otro, se seleccionan de hidrogeno, halogeno, C1-10-alquilo, C1-10-haloalquilo, C1-10-alcoxi y C1-10-haloalcoxi; siempre que al menos uno de L1, L2, L3 y L4 no sea hidrogeno; R1 y R2, independientemente uno del otro, se seleccionan de hidrogeno, C1-10-alquilo, C1-10-haloalquilo, C1-10-alcoxi y C1-10-haloalcoxi; R3 se selecciona de hidrogeno, C1-10-alquilo, C1-10-haloalquilo, C1-10-alcoxi y C1-10-haloalcoxi; R4 se selecciona de hidrogeno, C1-10-alquilo, C1-10-haloalquilo, C2-10-alquenilo, C2-10-haloalquenilo, C2-10-alquinilo, C2-10-haloalquinilo, C3-10-cicloalquilo, C3-10-halocicloalquilo, fenilo, fenil-C1-4-alquilo, donde la porcion de fenilo en los 2 ultimos radicales mencionados puede llevar 1, 2, 3, 4 o 5 sustituyentes R8, y un anillo heterocíclico de 5 o 6 miembros saturado, parcialmente insaturado o aromático que contiene 1, 2 o 3 heteroátomos seleccionados de N, O y S como miembros del anillo, en donde el anillo heterocíclico puede llevar 1, 2 o 3 sustituyentes R8, o, en caso que n sea 0, también se puede seleccionar de -C(=O)R5, -C(=S)R5, -S(O)2R5, -CN, -P(=Q)R6R7, M y un grupo de la formula 3 en donde L1, L2, L3, L4, R1, R2 y R3 son como se definen en las formulas 1 y 2; y es el punto de union con el resto de la molécula; R4a se selecciona de hidrogeno, C1-10-alquilo, C1-10-haloalquilo, C2-10-alquenilo, C2-10-haloalquenilo, C2-10-alquinilo, C2-10-haloalquinilo, C3-10-cicloalquilo, C3-10-halocicloalquilo, fenilo, fenil-C1-4-alquilo, donde la porcion de fenilo en los 2 ultimos radicales mencionados puede llevar 1, 2, 3, 4 o 5 sustituyentes R8, un anillo heterocíclico de 5 o 6 miembros saturado, parcialmente insaturado o aromático que contiene 1, 2 o 3 heteroátomos seleccionados de N, O y S como miembros del anillo, en donde el anillo heterocíclico puede llevar 1 2 o 3 sustituyentes R8, -C(O)R5, -C(=S)R5, -S(O)2R5, -CN, -P(=Q)R6R7 y M; R5 se selecciona de hidrogeno, C1-10-alquilo, C1-10-haloalquilo, C1-10-alcoxi, C1-10-haloalcoxi, C1-10-aminoalquilo, C3-10-cicloalquilo, C3-10-halocicloalquilo, fenilo, fenil-C1-4-alquilo, fenoxi, donde la porcion de fenilo en los 3 ultimos radicales mencionados puede llevar 1, 2, 3, 4 o 5 sustituyentes R8, un anillo heterocíclico de 5 o 6 miembros saturado, parcialmente insaturado o aromático que contiene 1, 2 o 3 heteroátomos seleccionados de N, O y S como miembros del anillo, en donde el anillo heterocíclico puede llevar 1, 2 o 3 sustituyentes R8, y NR9R10; R6 y R7, independientemente uno del otro, se seleccionan de C1-10-alquilo, C1-10-haloalquilo, C2-10-alquenilo, C2-10-haloalquenilo, C2-10-alquinilo, C2-10-haloalquinilo, C3-10-cicloalquilo, C3-10-halocicloalquilo, C1-10-alcoxi, C1-10-haloalcoxi, C1-4-alcoxi-C1-10-alquilo, C1-4-alcoxi-C1-10-alcoxi, C1-10-alquiltio, C1-10-haloalquiltio, C2-10-alqueniloxi, C2-10-alqueniltio, C2-10-alquiniloxi, C2-10-alquiniltio, C3-10-cicloalcoxi, C3-10-cicloalquiltio, fenilo, fenil-C1-4-alquilo, fenoxi, feniltio, fenil-C1-4-alcoxi, y NR11R12; cada R8 se selecciona independientemente de halogeno, nitro, CN, C1-4-alquilo, C1-4-haloalquilo, C1-4-alcoxi, C1-4-haloalcoxi y NR13R14; R9 se selecciona de hidrogeno y C1-8-alquilo; R10 se selecciona de hidrogeno, C1-8-alquilo, fenilo, y fenil-C1-4-alquilo o R9 y R10 en forma conjunta, forman un puente lineal de C4- o C5-alquileno o un grupo -CH2CH2OCH2CH2- o -CH2CH2NR15CH2CH2-; R11 se selecciona de hidrogeno y C1-8-alquilo; R12 se selecciona de hidrogeno, C1-8-alquilo, fenilo, y fenil-C1-4-alquilo; o R11 y R12 en forma conjunta, forman un puente lineal de C4- o C5-alquileno o un grupo -CH2CH2OCH2CH2- o -CH2CH2NR15CH2CH2-; R13 independientemente de cada acontecimiento, se selecciona de hidrogeno y C1-8-alquilo; R14 independientemente de cada acontecimiento, se selecciona de hidrogeno, C1-8-alquilo, fenilo, y fenil-C1-4-alquilo; o R13 y R14 en forma conjunta, forman un puente lineal de C4- o C5-alquileno o un grupo -CH2CH2OCH2CH2- o -CH2CH2NR15CH2CH2-; R15 independientemente de cada acontecimiento, se selecciona de hidrogeno y C1-4-alquilo; Q es O o S; M es un equivalente del cation metálico o un cation amonio de la formula (NraRbRcRd)+, en donde Ra, Rb, Rc y Rd, independientemente uno del otro, se seleccionan de hidrogeno, C1-10-alquilo, fenilo y bencilo, en donde la porcion de fenilo en los 2 ultimos radicales mencionados puede llevar 1, 2 o 3 sustituyentes independientemente seleccionados de halogeno, CN, nitro, C1-4-alquilo, C1-4-haloalquilo, C1-4-alcoxi, C1-4-haloalcoxi y NR13R14, n es 0, 1, 2 o 3; y la línea punteada es un enlace simple o doble; y sus sales aceptables en la agricultura.Agricultural compositions that contain them, their use as fungicides and intermediates used in the methods to produce them. Pharmaceutical compositions and their use as antiviral, antifungal and anticancer. Claim 1: Triazole compounds characterized in that they have formulas 1 and 2: wherein L1 and L4, independently of each other, are selected from hydrogen, bromine, iodine, C1-10-alkyl, C1-10-haloalkyl, C1-10 -alkoxy and C1-10-haloalkoxy; L2 and L3, independently of each other, are selected from hydrogen, halogen, C1-10-alkyl, C1-10-haloalkyl, C1-10-alkoxy and C1-10-haloalkoxy; provided that at least one of L1, L2, L3 and L4 is not hydrogen; R1 and R2, independently of each other, are selected from hydrogen, C1-10-alkyl, C1-10-haloalkyl, C1-10-alkoxy and C1-10-haloalkoxy; R3 is selected from hydrogen, C1-10-alkyl, C1-10-haloalkyl, C1-10-alkoxy and C1-10-haloalkoxy; R4 is selected from hydrogen, C1-10-alkyl, C1-10-haloalkyl, C2-10-alkenyl, C2-10-haloalkenyl, C2-10-alkynyl, C2-10-haloalkynyl, C3-10-cycloalkyl, C3- 10-halocycloalkyl, phenyl, phenyl-C1-4-alkyl, where the portion of phenyl in the last 2 radicals mentioned may carry 1, 2, 3, 4 or 5 R8 substituents, and a saturated 5- or 6-membered heterocyclic ring, partially unsaturated or aromatic containing 1, 2 or 3 heteroatoms selected from N, O and S as ring members, where the heterocyclic ring can carry 1, 2 or 3 R8 substituents, or, if n is 0, it is also you can select from -C (= O) R5, -C (= S) R5, -S (O) 2R5, -CN, -P (= Q) R6R7, M and a group of formula 3 where L1, L2 , L3, L4, R1, R2 and R3 are as defined in formulas 1 and 2; and is the point of union with the rest of the molecule; R4a is selected from hydrogen, C1-10-alkyl, C1-10-haloalkyl, C2-10-alkenyl, C2-10-haloalkenyl, C2-10-alkynyl, C2-10-haloalkynyl, C3-10-cycloalkyl, C3- 10-halocycloalkyl, phenyl, phenyl-C1-4-alkyl, where the portion of phenyl in the last 2 radicals mentioned may carry 1, 2, 3, 4 or 5 R8 substituents, a partially or saturated 6 or 6-membered heterocyclic ring unsaturated or aromatic containing 1, 2 or 3 heteroatoms selected from N, O and S as ring members, wherein the heterocyclic ring can carry 1 2 or 3 substituents R8, -C (O) R5, -C (= S) R5, -S (O) 2R5, -CN, -P (= Q) R6R7 and M; R5 is selected from hydrogen, C1-10-alkyl, C1-10-haloalkyl, C1-10-alkoxy, C1-10-haloalkoxy, C1-10-aminoalkyl, C3-10-cycloalkyl, C3-10-halocycloalkyl, phenyl, phenyl-C1-4-alkyl, phenoxy, where the portion of phenyl in the last 3 radicals mentioned may carry 1, 2, 3, 4 or 5 R8 substituents, a saturated, partially unsaturated or aromatic 5 or 6 membered heterocyclic ring that it contains 1, 2 or 3 heteroatoms selected from N, O and S as ring members, wherein the heterocyclic ring can carry 1, 2 or 3 R8 substituents, and NR9R10; R6 and R7, independently of each other, are selected from C1-10-alkyl, C1-10-haloalkyl, C2-10-alkenyl, C2-10-haloalkenyl, C2-10-alkynyl, C2-10-haloalkynyl, C3- 10-cycloalkyl, C3-10-halocycloalkyl, C1-10-alkoxy, C1-10-haloalkoxy, C1-4-alkoxy-C1-10-alkyl, C1-4-alkoxy-C1-10-alkoxy, C1-10- alkylthio, C1-10-haloalkylthio, C2-10-alkenyloxy, C2-10-alkenylthio, C2-10-alkynyloxy, C2-10-alkynylthio, C3-10-cycloalkoxy, C3-10-cycloalkylthio, phenyl, phenyl-C1- 4-alkyl, phenoxy, phenylthio, phenyl-C1-4-alkoxy, and NR11R12; each R8 is independently selected from halogen, nitro, CN, C1-4-alkyl, C1-4-haloalkyl, C1-4-alkoxy, C1-4-haloalkoxy and NR13R14; R9 is selected from hydrogen and C1-8-alkyl; R10 is selected from hydrogen, C1-8-alkyl, phenyl, and phenyl-C1-4-alkyl or R9 and R10 together, form a linear bridge of C4- or C5-alkylene or a group -CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2 -; R11 is selected from hydrogen and C1-8-alkyl; R12 is selected from hydrogen, C1-8-alkyl, phenyl, and phenyl-C1-4-alkyl; or R11 and R12 together, form a linear bridge of C4- or C5-alkylene or a group -CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2-; R13 independently of each event, is selected from hydrogen and C1-8-alkyl; R14 independently of each event, is selected from hydrogen, C1-8-alkyl, phenyl, and phenyl-C1-4-alkyl; or R13 and R14 together, form a linear bridge of C4- or C5-alkylene or a group -CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2-; R15 regardless of each event, is selected from hydrogen and C1-4-alkyl; Q is O or S; M is an equivalent of the metal cation or an ammonium cation of the formula (NraRbRcRd) +, where Ra, Rb, Rc and Rd, independently of each other, are selected from hydrogen, C1-10-alkyl, phenyl and benzyl, in where the portion of phenyl in the last 2 radicals mentioned may carry 1, 2 or 3 substituents independently selected from halogen, CN, nitro, C1-4-alkyl, C1-4-haloalkyl, C1-4-alkoxy, C1-4- haloalkoxy and NR13R14, n is 0, 1, 2 or 3; and the dotted line is a single or double bond; and its acceptable salts in agriculture.

ARP100101397A 2009-04-24 2010-04-26 TRIAZOL COMPOUNDS THAT CARRY A SUBSTITUTE OF SULFUR II AR076427A1 (en)

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012165499A1 (en) * 2011-05-31 2015-02-23 株式会社クレハ Triazole compounds and use thereof
WO2013084770A1 (en) * 2011-12-05 2013-06-13 株式会社クレハ Azole derivative, method for producing azole derivative, intermediate compound, drug for agricultural and horticultural applications, and industrial material protectant
EP2842947A4 (en) * 2012-04-18 2015-11-04 Kureha Corp Method for producing triazolyl methyl cycloalkanol derivative and triazolyl methyl cycloalkanol derivative-containing composition
KR101885219B1 (en) * 2013-08-27 2018-08-14 시노켐 코포레이션 Applications of Substituent Benzyloxy Group Containing Ether Compounds for Preparing Antitumor Drugs
US10201158B2 (en) 2014-03-20 2019-02-12 Mitsui Chemicals Agro, Inc. Plant disease control composition and method for controlling plant disease by application of same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07614B2 (en) * 1986-08-08 1995-01-11 呉羽化学工業株式会社 Novel tricyclic azole derivative, method for producing the same, and agricultural / horticultural fungicide containing the derivative as an active ingredient
JPH0625140B2 (en) * 1986-11-10 1994-04-06 呉羽化学工業株式会社 Novel azole derivative, method for producing the same and agricultural / horticultural drug of the derivative
MA21706A1 (en) * 1988-12-29 1990-07-01 Rhone Poulenc Agrochimie BENZOLIDENE AZOLYLMETHYLCYCLOALCANE AND USE AS A FUNGICIDE.
JPH03197464A (en) * 1989-12-16 1991-08-28 Basf Ag Substituted azolylmethylcycloalkanol and bactericide containing same
JPH07138234A (en) * 1993-11-11 1995-05-30 Kureha Chem Ind Co Ltd Production of azolymethylcycloalkanol derivative
DE19520096A1 (en) * 1995-06-01 1996-12-05 Bayer Ag Cycloalkane benzylidene derivatives
DE19520098A1 (en) * 1995-06-01 1996-12-05 Bayer Ag Triazolylmethyl-cyclopentanols
DE19617282A1 (en) * 1996-04-30 1997-11-06 Bayer Ag Triazolyl mercaptide
DE19617461A1 (en) * 1996-05-02 1997-11-06 Bayer Ag Acylmercapto triazolyl derivatives
DE19619544A1 (en) * 1996-05-15 1997-11-20 Bayer Ag Triazolyl disulfides
DE19620407A1 (en) * 1996-05-21 1997-11-27 Bayer Ag Thiocyano-triazolyl derivatives
DE19620590A1 (en) * 1996-05-22 1997-11-27 Bayer Ag Sulfonyl-mercapto-triazolyl derivatives

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