AR076188A1 - Derivados de oxadiazol - Google Patents
Derivados de oxadiazolInfo
- Publication number
- AR076188A1 AR076188A1 ARP100101117A ARP100101117A AR076188A1 AR 076188 A1 AR076188 A1 AR 076188A1 AR P100101117 A ARP100101117 A AR P100101117A AR P100101117 A ARP100101117 A AR P100101117A AR 076188 A1 AR076188 A1 AR 076188A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- denotes
- coor3
- ocf3
- denote
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos son utiles, por ejemplos en el tratamiento de trastornos autoinmunes, como, por ejemplo, la esclerosis multiple Reivindicacion 1: Derivado de oxadiazol de formula (1) donde R1, R2 de manera independiente uno del otro denotan H, Hal, CF3, OCF3, CN, o NO2, OH, S es OR3 o COOR3, Q denota (CH2)mX(CH2)m*, X es -NA-; W denota CH, Ra es un grupo de formula (2) donde Rs denota Hal, A, OR3, N(R3)2, NO2, CN, COOR3, CF3, OCF3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, SOA o SO2A, y G1, G2 de manera independiente uno del otro denotan H, Hal, o CH3, con preferencias H; Rb es A, CF3, CH3, Hal, OCF3, CN, NO2, N(R3)2, CH2(NR3)2, A denota un alquilo lineal o ramificado C1-6 con preferencia C1-3 donde un átomo de H puede ser reemplazado por Hal, OH, COOR3, CN, N(R3)2 y donde un grupo CH2 puede estar reemplazado por O, -NR3-, -NR3CO-, -CO- o S y/o por grupos -CH=CH- o -C:::C-, R3 es H o A m* es 1, 2, 3, 4. 5, 6, 7 u 8, y m es 1, 2, 3, 4, 5, 6, 7 u 8 donde por lo menos uno de Ra y Rb denota CF3, y sus derivados, solvatos, tautomeros, sales y estereoisomeros farmacéuticamente aceptables, con inclusion de sus mezclas en todas las relaciones.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09157301A EP2241558A1 (en) | 2009-04-03 | 2009-04-03 | Oxadiazole derivatives |
| US16977309P | 2009-04-16 | 2009-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076188A1 true AR076188A1 (es) | 2011-05-26 |
Family
ID=40792794
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101116A AR076187A1 (es) | 2009-04-03 | 2010-04-05 | Derivados de oxadiazol, proceso de preparacion de los mismos y composicion farmaceutica que los contienen |
| ARP100101117A AR076188A1 (es) | 2009-04-03 | 2010-04-05 | Derivados de oxadiazol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101116A AR076187A1 (es) | 2009-04-03 | 2010-04-05 | Derivados de oxadiazol, proceso de preparacion de los mismos y composicion farmaceutica que los contienen |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8802704B2 (es) |
| EP (3) | EP2241558A1 (es) |
| JP (2) | JP5833538B2 (es) |
| KR (2) | KR20110135987A (es) |
| CN (2) | CN102803238B (es) |
| AR (2) | AR076187A1 (es) |
| AU (2) | AU2010233932B2 (es) |
| BR (2) | BRPI1013422A2 (es) |
| CA (2) | CA2755928C (es) |
| EA (2) | EA201171210A1 (es) |
| ES (2) | ES2639028T3 (es) |
| IL (2) | IL215497B (es) |
| MX (2) | MX2011010451A (es) |
| SG (2) | SG174449A1 (es) |
| WO (2) | WO2010112461A1 (es) |
| ZA (2) | ZA201106855B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2241558A1 (en) * | 2009-04-03 | 2010-10-20 | Merck Serono SA | Oxadiazole derivatives |
| TW201206429A (en) * | 2010-07-08 | 2012-02-16 | Merck Serono Sa | Substituted oxadiazole derivatives |
| CA2814628C (en) * | 2010-10-14 | 2015-06-16 | Daiichi Sankyo Company, Limited | Acylbenzene derivative |
| EP2805941B1 (en) | 2012-01-18 | 2016-08-17 | Daiichi Sankyo Company, Limited | Substituted phenylazole derivative |
| ES2782509T3 (es) | 2012-07-02 | 2020-09-15 | Monsanto Technology Llc | Procedimiento para la preparación de 1,2,4-oxadiazoles 3,5-disustituidos |
| EP2958913B1 (en) | 2013-02-20 | 2018-10-03 | LG Chem, Ltd. | Sphingosine-1-phosphate receptor agonists, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent |
| CN103450171B (zh) * | 2013-09-22 | 2015-07-08 | 苏州康乃德生物医药有限公司 | 一种免疫调节化合物、其用途和包含其的药物组合物 |
| US9828351B2 (en) * | 2014-06-26 | 2017-11-28 | Monash University | Enzyme interacting agents |
| CN108348527A (zh) * | 2015-10-30 | 2018-07-31 | Ptc医疗公司 | 用于治疗癫痫的方法 |
| WO2018187479A1 (en) | 2017-04-04 | 2018-10-11 | Case Western Reserve University | Method of modulating ribonucleotide reductase |
| US10676467B2 (en) | 2017-06-30 | 2020-06-09 | Washington University | Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof |
| CN107827837B (zh) * | 2017-11-21 | 2021-09-24 | 苏州朗科生物技术股份有限公司 | 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用 |
| CN109956912B (zh) * | 2017-12-26 | 2021-10-22 | 中国医学科学院药物研究所 | 含二苯基噁二唑的羧酸类化合物、其制备方法及医药用途 |
| CN109761827A (zh) * | 2019-02-18 | 2019-05-17 | 湖南科瑞生物制药股份有限公司 | 一种n-苄基乙醇胺的制备方法 |
| CN110987847B (zh) * | 2019-12-11 | 2021-02-19 | 苏州今蓝纳米科技有限公司 | 1,3,4-噁二唑衍生物在检测酸以及数据加密和储存中的应用 |
| CN116041277B (zh) * | 2023-01-18 | 2024-11-01 | 中国药科大学 | 苯基和联苯基取代的五元杂环类化合物及其制备方法、药物组合物和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003062248A2 (en) * | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists |
| US7605171B2 (en) * | 2003-12-17 | 2009-10-20 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists |
| EP1893591A1 (en) * | 2005-06-08 | 2008-03-05 | Novartis AG | POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS |
| GB0511684D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| JP2010504932A (ja) * | 2006-09-29 | 2010-02-18 | ノバルティス アーゲー | 抗炎症および免疫抑制特性を有するオキサジアゾール誘導体 |
| GB0625648D0 (en) * | 2006-12-21 | 2007-01-31 | Glaxo Group Ltd | Compounds |
| JO2701B1 (en) * | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
| EP2125797B1 (en) * | 2007-03-16 | 2014-01-15 | Actelion Pharmaceuticals Ltd. | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
| EP2014653A1 (en) * | 2007-06-15 | 2009-01-14 | Bioprojet | Novel dicarboxylic acid derivatives as S1P1 receptor agonists |
| WO2009043889A2 (en) * | 2007-10-04 | 2009-04-09 | Merck Serono S.A. | Oxadiazole derivatives |
| EP2241558A1 (en) * | 2009-04-03 | 2010-10-20 | Merck Serono SA | Oxadiazole derivatives |
-
2009
- 2009-04-03 EP EP09157301A patent/EP2241558A1/en not_active Withdrawn
-
2010
- 2010-03-29 WO PCT/EP2010/054103 patent/WO2010112461A1/en not_active Ceased
- 2010-03-29 SG SG2011067246A patent/SG174449A1/en unknown
- 2010-03-29 EP EP10711881.2A patent/EP2414341B1/en active Active
- 2010-03-29 AU AU2010233932A patent/AU2010233932B2/en not_active Ceased
- 2010-03-29 ES ES10713159.1T patent/ES2639028T3/es active Active
- 2010-03-29 SG SG2011067238A patent/SG174448A1/en unknown
- 2010-03-29 MX MX2011010451A patent/MX2011010451A/es not_active Application Discontinuation
- 2010-03-29 JP JP2012502620A patent/JP5833538B2/ja not_active Expired - Fee Related
- 2010-03-29 CN CN201080025137.2A patent/CN102803238B/zh not_active Expired - Fee Related
- 2010-03-29 BR BRPI1013422A patent/BRPI1013422A2/pt not_active IP Right Cessation
- 2010-03-29 KR KR1020117026161A patent/KR20110135987A/ko not_active Withdrawn
- 2010-03-29 CA CA2755928A patent/CA2755928C/en not_active Expired - Fee Related
- 2010-03-29 BR BRPI1015048A patent/BRPI1015048A2/pt not_active IP Right Cessation
- 2010-03-29 KR KR1020117025727A patent/KR20120002606A/ko not_active Withdrawn
- 2010-03-29 EA EA201171210A patent/EA201171210A1/ru unknown
- 2010-03-29 US US13/260,789 patent/US8802704B2/en not_active Expired - Fee Related
- 2010-03-29 CN CN2010800251762A patent/CN102459206A/zh active Pending
- 2010-03-29 WO PCT/EP2010/054100 patent/WO2010115751A2/en not_active Ceased
- 2010-03-29 US US13/260,779 patent/US8815919B2/en not_active Expired - Fee Related
- 2010-03-29 ES ES10711881.2T patent/ES2652183T3/es active Active
- 2010-03-29 JP JP2012502619A patent/JP5833537B2/ja not_active Expired - Fee Related
- 2010-03-29 AU AU2010230314A patent/AU2010230314B2/en not_active Ceased
- 2010-03-29 CA CA2755918A patent/CA2755918C/en not_active Expired - Fee Related
- 2010-03-29 EA EA201171211A patent/EA020691B1/ru not_active IP Right Cessation
- 2010-03-29 MX MX2011010449A patent/MX2011010449A/es active IP Right Grant
- 2010-03-29 EP EP10713159.1A patent/EP2414342B1/en active Active
- 2010-04-05 AR ARP100101116A patent/AR076187A1/es unknown
- 2010-04-05 AR ARP100101117A patent/AR076188A1/es not_active Application Discontinuation
-
2011
- 2011-09-20 ZA ZA2011/06855A patent/ZA201106855B/en unknown
- 2011-09-20 ZA ZA2011/06854A patent/ZA201106854B/en unknown
- 2011-10-03 IL IL215497A patent/IL215497B/en active IP Right Grant
- 2011-10-03 IL IL215498A patent/IL215498A/en active IP Right Grant
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |