AR076177A1 - MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL - Google Patents
MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORALInfo
- Publication number
- AR076177A1 AR076177A1 ARP100101094A ARP100101094A AR076177A1 AR 076177 A1 AR076177 A1 AR 076177A1 AR P100101094 A ARP100101094 A AR P100101094A AR P100101094 A ARP100101094 A AR P100101094A AR 076177 A1 AR076177 A1 AR 076177A1
- Authority
- AR
- Argentina
- Prior art keywords
- oral cavity
- condition
- matrix metalloproteinases
- expression
- positive control
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56955—Bacteria involved in periodontal diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Reivindicacion 1: Un método para identificar un compuesto que es util para tratar una enfermedad o condicion de la cavidad oral, caracterizado por que comprende: Obtener una primera muestra gingival, a partir de un mamífero que sufre de una enfermedad o condicion de la cavidad oral; Obtener una segunda muestra gingival de la cavidad oral de dicho mamífero; contactar dicha primera muestra con un compuesto de prueba; contactar dicha segunda muestra con un control positivo, en donde dicho control positivo es un compuesto conocido por regular decrecientemente la expresion de uno o más metaloproteinasas de matriz; Medir la extension a la cual la expresion de uno o más de dicha metaloproteinasas de matriz que es regulada decrecientemente por dicho compuesto de prueba; Medir la extension a la cual la expresion de uno o más de dicha metaloproteinasas de matriz es regulada decrecientemente, por dicho control positivo; y comparar la extension a la cual la expresion de una o más de dicha metaloproteinasas de matriz es regulada decrecientemente, por dicho compuesto de prueba, con la medida con la que la expresion de uno o más de dichas metaloproteinasas de matriz es regulada decrecientemente por dicho control positivo; en donde un compuesto de prueba que regula decrecientemente la expresion de uno o más de dichas metaloproteinasas de matriz a una medida igual o mayor que la de dicho control positivo, es un compuesto util en tratar una enfermedad o condicion de una cavidad oral. Reivindicacion 2: El método de la reivindicacion 1, caracterizado por que dicha una o más metaloproteinasas de matriz son seleccionadas del grupo que consiste de: MMP-8, MMP-9, y MMP-13. Reivindicacion 4: El método de cualquiera de las reivindicaciones precedentes, caracterizado por que dicha enfermedad o condicion de la cavidad oral, es una gingivitis o periodontitis. Reivindicacion 6: El método de cualquiera de las reivindicaciones precedentes, caracterizado por que el control positivo es triclosán.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16568509P | 2009-04-01 | 2009-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076177A1 true AR076177A1 (es) | 2011-05-26 |
Family
ID=42328354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101094A AR076177A1 (es) | 2009-04-01 | 2010-03-31 | MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8637266B2 (es) |
| EP (1) | EP2414838B1 (es) |
| JP (1) | JP5330596B2 (es) |
| CN (1) | CN102365550B (es) |
| AR (1) | AR076177A1 (es) |
| AU (1) | AU2010232590B2 (es) |
| BR (1) | BRPI1013185A2 (es) |
| CA (1) | CA2757317C (es) |
| CO (1) | CO6420374A2 (es) |
| DK (1) | DK2414838T3 (es) |
| ES (1) | ES2432864T3 (es) |
| MX (1) | MX2011008438A (es) |
| MY (1) | MY158406A (es) |
| PL (1) | PL2414838T3 (es) |
| RU (1) | RU2524629C2 (es) |
| SG (1) | SG173487A1 (es) |
| TW (1) | TWI405565B (es) |
| WO (1) | WO2010115031A1 (es) |
| ZA (1) | ZA201106054B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101745067B1 (ko) * | 2014-12-31 | 2017-06-12 | 서울대학교산학협력단 | 치주질환 예측 시스템 및 이를 이용한 치주질환 예측 방법 |
| KR102098624B1 (ko) * | 2019-09-20 | 2020-04-08 | 서울대학교산학협력단 | 타액 mmp-9 및 il-8를 이용한 치주염 예측 시스템 및 이를 이용한 치주염 예측 방법 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US4358437A (en) | 1978-11-29 | 1982-11-09 | Beecham Group Limited | Compositions |
| US5288480A (en) | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
| US5032386A (en) | 1988-12-29 | 1991-07-16 | Colgate-Palmolive Company | Antiplaque antibacterial oral composition |
| US4894220A (en) | 1987-01-30 | 1990-01-16 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| GB9117140D0 (en) | 1991-08-08 | 1991-09-25 | Unilever Plc | Treatment of periodontitis |
| DE4226043A1 (de) | 1992-08-06 | 1994-02-10 | Haarmann & Reimer Gmbh | Mittel mit physiologischem Kühleffekt und für diese Mittel geeignete wirksame Verbindungen |
| US5756361A (en) * | 1992-12-17 | 1998-05-26 | Metra Biosystems, Inc. | Screening method for periodontal disease |
| US5840302A (en) | 1993-11-10 | 1998-11-24 | Bristol-Myers Squibb Company | Treatment of bacterially-induced inflammatory diseases |
| FI98961C (fi) * | 1994-08-26 | 1997-09-10 | Medix Biochemica Ab Oy | Menetelmät ja määritysvälineet parodontaalisairauden aktiivisuuden ja/tai peri-implantiitin ja/tai niiden kohonneen riskin diagnosoimiseksi |
| US5578295A (en) | 1995-04-28 | 1996-11-26 | The Procter & Gamble Company | Oral care compositions comprising certain substituted diphenyl ethers |
| US6482418B1 (en) | 1996-06-12 | 2002-11-19 | Henkel Kommanditgesellschaft Auf Aktien | Cosmetic and/or pharmaceutical preparations comprising dialkenyl carbonates |
| US5998487A (en) * | 1998-04-08 | 1999-12-07 | Colgate-Palmolive Company | Anti-inflammatory and antibacterial benzyl phenol agents and their use in oral compositions |
| JP3763075B2 (ja) * | 1998-04-24 | 2006-04-05 | サンスター株式会社 | 歯周病の予防又は治療用の食品組成物、口腔用組成物及び医薬組成物 |
| FR2794457B1 (fr) | 1999-06-01 | 2001-08-10 | Oreal | Derives carbonates de retinol, procede de preparation et utilisations |
| US6165447A (en) * | 1999-06-15 | 2000-12-26 | Colgate-Palmolive Company | Synergistic antibacterial combination |
| JP2003518627A (ja) | 1999-12-03 | 2003-06-10 | バクスター・インターナショナル・インコーポレイテッド | 自動イムノアッセイシステムを用いる使用のための発熱性試験 |
| GB0001704D0 (en) | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US20020009740A1 (en) | 2000-04-14 | 2002-01-24 | Rima Kaddurah-Daouk | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US6500409B1 (en) | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| DE10059584A1 (de) | 2000-11-30 | 2002-06-06 | Beiersdorf Ag | Kosmetische oder dermatologische getränkte Tücher |
| DOP2002000332A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
| MXPA05001786A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de azaisoquinolina como inhibidores de la metaloproteinasa de matriz. |
| US7005225B2 (en) | 2002-11-12 | 2006-02-28 | Samsung Electronics Company | Organosol including amphipathic copolymeric binder having crystalline material, and use of the organosol to make dry tones for electrographic applications |
| CA2514061A1 (en) | 2003-02-14 | 2004-09-02 | Combinatorx, Incorporated | Combination therapy for the treatment of immunoinflammatory disorders |
| GB2401865A (en) | 2003-05-22 | 2004-11-24 | Givaudan Sa | Antibacterial and antifungal glycerol monocarbonates |
| US7202234B2 (en) | 2003-10-24 | 2007-04-10 | Eisai Co., Ltd. | Compounds and methods for treating Toll-like receptor 2-related diseases and conditions |
| AU2004297914A1 (en) | 2003-12-03 | 2005-06-23 | Whitehead Institute For Biomedical Research | Use of T-cadherin as a target |
| FI20040572A0 (fi) * | 2004-04-23 | 2004-04-23 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasin aktiviteetin inhibiittorit |
| JP4662043B2 (ja) * | 2004-09-09 | 2011-03-30 | 国立大学法人東京農工大学 | 歯周病発症の評価システム |
| CN101111288A (zh) * | 2004-12-02 | 2008-01-23 | 高露洁-棕榄公司 | 含酚类化合物和抗氧化剂维生素和维生素衍生物的口腔护理组合物 |
| US20060141421A1 (en) | 2004-12-28 | 2006-06-29 | Kimberly-Clark Worldwide, Inc. | System and method for detecting substances related to oral health |
| WO2006074450A2 (en) | 2005-01-07 | 2006-07-13 | President And Fellows Of Harvard College | Methods and compositions for detecting and modulating periodontal disorders and periodontal diseases |
| JP5024506B2 (ja) * | 2005-03-25 | 2012-09-12 | ライオン株式会社 | 歯周組織破壊の抑制・改善剤及び口腔用組成物 |
| JP2009523029A (ja) | 2006-01-10 | 2009-06-18 | コルゲート・パーモリブ・カンパニー | 炎症の予防または軽減のために、細胞表面受容体を調節する方法 |
| US20080161394A1 (en) | 2006-11-23 | 2008-07-03 | Jean-Yves Fouron | Cosmetic composition comprising at least one volatile carbonic acid ester |
| WO2008093072A2 (en) | 2007-01-29 | 2008-08-07 | Paul Webb | Topical composition against contact dermatitis due to water |
| WO2009048841A1 (en) | 2007-10-09 | 2009-04-16 | Humco Holding Group, Inc. | Antifungal treatment of nails |
| AR076041A1 (es) * | 2009-04-01 | 2011-05-11 | Colgate Palmolive Co | Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral |
-
2010
- 2010-03-31 AR ARP100101094A patent/AR076177A1/es unknown
- 2010-03-31 TW TW099109773A patent/TWI405565B/zh not_active IP Right Cessation
- 2010-04-01 DK DK10712854.8T patent/DK2414838T3/da active
- 2010-04-01 WO PCT/US2010/029670 patent/WO2010115031A1/en not_active Ceased
- 2010-04-01 ES ES10712854T patent/ES2432864T3/es active Active
- 2010-04-01 CN CN201080015649.0A patent/CN102365550B/zh not_active Expired - Fee Related
- 2010-04-01 MY MYPI2011003577A patent/MY158406A/en unknown
- 2010-04-01 JP JP2012503715A patent/JP5330596B2/ja not_active Expired - Fee Related
- 2010-04-01 AU AU2010232590A patent/AU2010232590B2/en not_active Ceased
- 2010-04-01 EP EP10712854.8A patent/EP2414838B1/en not_active Revoked
- 2010-04-01 CA CA2757317A patent/CA2757317C/en not_active Expired - Fee Related
- 2010-04-01 PL PL10712854T patent/PL2414838T3/pl unknown
- 2010-04-01 BR BRPI1013185A patent/BRPI1013185A2/pt not_active IP Right Cessation
- 2010-04-01 SG SG2011055332A patent/SG173487A1/en unknown
- 2010-04-01 US US13/262,027 patent/US8637266B2/en active Active
- 2010-04-01 RU RU2011144028/15A patent/RU2524629C2/ru not_active IP Right Cessation
- 2010-04-01 MX MX2011008438A patent/MX2011008438A/es active IP Right Grant
-
2011
- 2011-08-17 ZA ZA2011/06054A patent/ZA201106054B/en unknown
- 2011-09-06 CO CO11114807A patent/CO6420374A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW201039812A (en) | 2010-11-16 |
| AU2010232590B2 (en) | 2013-03-07 |
| HK1167272A1 (en) | 2012-11-23 |
| TWI405565B (zh) | 2013-08-21 |
| MY158406A (en) | 2016-10-14 |
| EP2414838B1 (en) | 2013-08-28 |
| US8637266B2 (en) | 2014-01-28 |
| RU2011144028A (ru) | 2013-05-10 |
| CA2757317C (en) | 2014-03-11 |
| JP2012524884A (ja) | 2012-10-18 |
| JP5330596B2 (ja) | 2013-10-30 |
| CO6420374A2 (es) | 2012-04-16 |
| MX2011008438A (es) | 2011-09-06 |
| PL2414838T3 (pl) | 2014-01-31 |
| SG173487A1 (en) | 2011-09-29 |
| WO2010115031A1 (en) | 2010-10-07 |
| EP2414838A1 (en) | 2012-02-08 |
| ZA201106054B (en) | 2014-01-29 |
| CA2757317A1 (en) | 2010-10-07 |
| CN102365550B (zh) | 2014-08-13 |
| DK2414838T3 (da) | 2013-11-04 |
| RU2524629C2 (ru) | 2014-07-27 |
| CN102365550A (zh) | 2012-02-29 |
| ES2432864T3 (es) | 2013-12-05 |
| US20120107843A1 (en) | 2012-05-03 |
| BRPI1013185A2 (pt) | 2016-04-12 |
| AU2010232590A1 (en) | 2011-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |