AR075838A1 - Derivados de n-((6-aza-biciclo(3.2.1)oct-5-il)-aril-metil)-heterobenzamida, su preparacion y su aplicacion en terapeutica. - Google Patents
Derivados de n-((6-aza-biciclo(3.2.1)oct-5-il)-aril-metil)-heterobenzamida, su preparacion y su aplicacion en terapeutica.Info
- Publication number
- AR075838A1 AR075838A1 ARP100100801A ARP100100801A AR075838A1 AR 075838 A1 AR075838 A1 AR 075838A1 AR P100100801 A ARP100100801 A AR P100100801A AR P100100801 A ARP100100801 A AR P100100801A AR 075838 A1 AR075838 A1 AR 075838A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- groups
- cycloalkyl
- alkoxy
- heterobenzamida
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 halo- C1-6 alkyl Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuesto de formula general (1) en la que: R representa un átomo de hidrogeno o un grupo elegido entre los grupos alquilo C1-6 o cicloalquilo C3-7 opcionalmente sustituido con uno o varios grupos elegidos independientemente entre sí entre el átomo de halogeno, los grupos cicloalquilo C3-7, alquilo C1-6, alcoxi C1-6, hidroxi; R1 representa un grupo fenilo opcionalmente sustituido con uno o varios sustituyentes elegidos independientemente entre sí entre los átomos de halogeno, los grupos alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, hidroxi, halo-alcoxi C1-6, alquil C1-6-tio, alquil C1-6-SO, alquil C1-6-SO2; R2 representa uno o varios sustituyentes elegidos entre el átomo de hidrogeno, los átomos de halogeno, los grupos halo-alquilo C1-6, alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-3, fenil, bencil, alcoxi C1-6, alquil C1-6-tio, alquil C1-6-SO, alquil C1-6-SO2; Het representa un grupo heteroarilo; en forma de base o de sal de adicion a un ácido. Procedimiento de síntesis, composicion farmacéutica y uso como reguladores de transportadores de la glicina Glyt1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901220A FR2943059A1 (fr) | 2009-03-16 | 2009-03-16 | Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075838A1 true AR075838A1 (es) | 2011-04-27 |
Family
ID=40720092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100801A AR075838A1 (es) | 2009-03-16 | 2010-03-15 | Derivados de n-((6-aza-biciclo(3.2.1)oct-5-il)-aril-metil)-heterobenzamida, su preparacion y su aplicacion en terapeutica. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20120029027A1 (es) |
| EP (1) | EP2408778A1 (es) |
| JP (1) | JP2012520346A (es) |
| KR (1) | KR20120013325A (es) |
| CN (1) | CN102356084A (es) |
| AR (1) | AR075838A1 (es) |
| AU (1) | AU2010224721A1 (es) |
| BR (1) | BRPI1009497A2 (es) |
| CA (1) | CA2755528A1 (es) |
| FR (1) | FR2943059A1 (es) |
| IL (1) | IL215103A0 (es) |
| MX (1) | MX2011009746A (es) |
| RU (1) | RU2011141760A (es) |
| SG (1) | SG174432A1 (es) |
| TW (1) | TW201100431A (es) |
| UY (1) | UY32496A (es) |
| WO (1) | WO2010106270A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| CA3252823A1 (en) | 2016-06-13 | 2025-02-25 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| KR102269305B1 (ko) | 2016-06-13 | 2021-06-25 | 길리애드 사이언시즈, 인코포레이티드 | Fxr (nr1h4) 조정 화합물 |
| KR20220119520A (ko) | 2017-03-28 | 2022-08-29 | 길리애드 사이언시즈, 인코포레이티드 | 간 질환을 치료하기 위한 치료 조합물 |
| BR112021011762A2 (pt) | 2019-01-15 | 2021-11-03 | Gilead Sciences Inc | Compostos para modulação de fxr (nr1h4) |
| KR102725082B1 (ko) | 2019-02-19 | 2024-11-04 | 길리애드 사이언시즈, 인코포레이티드 | Fxr 효능제의 고체 형태 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
| WO2009013535A1 (en) * | 2007-07-23 | 2009-01-29 | Astrazeneca Ab | 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor |
-
2009
- 2009-03-16 FR FR0901220A patent/FR2943059A1/fr active Pending
-
2010
- 2010-03-15 CN CN2010800121523A patent/CN102356084A/zh active Pending
- 2010-03-15 EP EP10715933A patent/EP2408778A1/fr not_active Withdrawn
- 2010-03-15 SG SG2011066842A patent/SG174432A1/en unknown
- 2010-03-15 KR KR1020117024140A patent/KR20120013325A/ko not_active Withdrawn
- 2010-03-15 TW TW099107513A patent/TW201100431A/zh unknown
- 2010-03-15 WO PCT/FR2010/050448 patent/WO2010106270A1/fr not_active Ceased
- 2010-03-15 AR ARP100100801A patent/AR075838A1/es unknown
- 2010-03-15 CA CA2755528A patent/CA2755528A1/fr not_active Abandoned
- 2010-03-15 JP JP2012500293A patent/JP2012520346A/ja not_active Withdrawn
- 2010-03-15 RU RU2011141760/04A patent/RU2011141760A/ru unknown
- 2010-03-15 US US13/256,834 patent/US20120029027A1/en not_active Abandoned
- 2010-03-15 AU AU2010224721A patent/AU2010224721A1/en not_active Abandoned
- 2010-03-15 BR BRPI1009497-0A patent/BRPI1009497A2/pt not_active IP Right Cessation
- 2010-03-15 MX MX2011009746A patent/MX2011009746A/es not_active Application Discontinuation
- 2010-03-16 UY UY0001032496A patent/UY32496A/es not_active Application Discontinuation
-
2011
- 2011-09-12 IL IL215103A patent/IL215103A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120013325A (ko) | 2012-02-14 |
| MX2011009746A (es) | 2011-09-29 |
| WO2010106270A1 (fr) | 2010-09-23 |
| JP2012520346A (ja) | 2012-09-06 |
| CA2755528A1 (fr) | 2010-09-23 |
| CN102356084A (zh) | 2012-02-15 |
| AU2010224721A1 (en) | 2011-10-06 |
| BRPI1009497A2 (pt) | 2018-03-13 |
| FR2943059A1 (fr) | 2010-09-17 |
| RU2011141760A (ru) | 2013-04-27 |
| SG174432A1 (en) | 2011-10-28 |
| IL215103A0 (en) | 2011-12-29 |
| US20120029027A1 (en) | 2012-02-02 |
| TW201100431A (en) | 2011-01-01 |
| EP2408778A1 (fr) | 2012-01-25 |
| UY32496A (es) | 2010-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |