AR074790A1 - Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. - Google Patents
Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente.Info
- Publication number
- AR074790A1 AR074790A1 ARP090104966A ARP090104966A AR074790A1 AR 074790 A1 AR074790 A1 AR 074790A1 AR P090104966 A ARP090104966 A AR P090104966A AR P090104966 A ARP090104966 A AR P090104966A AR 074790 A1 AR074790 A1 AR 074790A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- cyano
- independently
- haloalkyl
- Prior art date
Links
- 244000045947 parasite Species 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical group C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 229910052757 nitrogen Inorganic materials 0.000 abstract 10
- -1 C1-6- alkoxy Chemical group 0.000 abstract 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 8
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 6
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 5
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 5
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 4
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 abstract 3
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005347 halocycloalkyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 244000078703 ectoparasite Species 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Los compuestos de fórmula (1) son útiles en el control de parásitos, en particular ectoparásitos, en y sobre animales de sangre caliente. Reivindicación 1: Un compuesto de fórmula (1) que incluye todos los geométricos y estereoisómeros, N-óxidos, y sales de los mismos, en donde X es S(O)m, O ó NR5' y X1 y X2 son cada uno independientemente del otro CR3' o N; n es un entero de 0 a 4; m es un entero de 0 a 2; B1, B2 y B3 se seleccionan cada uno independientemente del grupo que consiste de CR2' y N; cada R2' es independientemente del otro H o R2; cada R3' es independientemente del otro H o R3; R1 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7 o cicloalquilalquilo C4-7, cada uno no sustituido o sustituido con uno o más sustituyentes independientemente seleccionados de R4; R4 es halógeno, alquilo C1-6, alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano o nitro; cada R2 es independientemente halógeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, N-mono o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano (-CN) o nitro (-NO2); cada R3 es independientemente H, halógeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, amino, N-mono- o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano o nitro o no sustituido o halógeno-, alquilo C1-6-, haloalquilo C1-6-, alcoxi C1-6-, haloalcoxi C1-6-, amino-, ciano- o fenilo sustituido con nitro, piridilo o pirimidilo; Z es halógeno, un radical Q o un grupo -C(W)-NR5R6; Q es un anillo heterocíclico de 5 ó 6 miembros o un sistema de anillo carbocíclico C6-10 o un sistema de anillo hetero-bicíclico fusionado de a 8, 9 ó 10-miembros, cada uno de los cuales es no sustituido o sustituido con uno o más sustituyentes independientemente seleccionados de halógeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, ciano, nitro, amino, N-mono- o N,N-di-alquilamino C1-4, alcoxicarbonilo C1-6, sulfonamido, N-mono- o N,N,di-alquilsulfonamino C1-4, alquilcarbonilamino C1-6, N-mono- o N,N-di-alquilaminocarbonilo C1-6, alcanoilo C2-6, un grupo -(alqu)-C(W')NR5''R7, fenilo, bencilo, benzoilo, fenoxi, piridilo, piridil-(alqu)-, pirimidilo y pirimidil-(alqu)-, en donde el fenilo, bencilo, benzoilo, fenoxi, piridilo y pirimidilo son cada uno no sustituido o sustituido por halógeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, ciano, nitro o amino; (alqu) es alquileno C1-6 de cadena recta o ramificada; W y W' son cada uno independientemente del otro O ó S; R5, R5' y R5'' son cada uno independientemente del otro H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7, cicloalquilalquilo C4-7, alquilcarbonilo C1-6 o alcoxicarbonilo C1-6; R6 es H; Q', en donde Q' tiene independientemente el mismo significado de Q; o es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7, o cicloalquilalquilo C4-7, cada uno no sustituido o sustituido por halógeno alcoxi C1-6, alquiltio C1-6. alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano, nitro, amino, N-mono- o N,N-dialquilamino C1-6, cicloalquilamino C3-6, alcoxicarbonilo C1-6, alcanoilo C2-6, alquilcarbonilamino C1-6, aminocarbonilo, N-mono- o N,N-di-alquilaminocarbonilo C1-6, un grupo -C(W')NR5''R7 o un radical Q'', en donde Q'' independientemente tiene el mismo significado de Q; o R5 y R6 junto con el átomo de N al cual ellos se adhieren, forman un anillo de 3 a 7 miembros que opcionalmente contiene un heteroátomo adicional seleccionado del grupo que consiste de N, S y O y cuyo anillo es adicionalmente no sustituido o sustituido por alquilo C1-2, alquilo C1-2, alcoxi C1-2, halógeno, ciano o nitro; y R7 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7 o cicloalquilalquilo C4-7, que es cada uno no sustituido o sustituido por halógeno alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano, nitro, amino, N-mono- o N,N-di-alquilamino C1-6, piridilo, pirimidilo o tiazolilo, o por piridilo, pirimidilo o tiazolilo que es mono- o disustituido por halógeno, ciano, alquilo C1-2 o haloalquilo C1-2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08172398 | 2008-12-19 | ||
| CH11842009 | 2009-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074790A1 true AR074790A1 (es) | 2011-02-09 |
Family
ID=42235717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104966A AR074790A1 (es) | 2008-12-19 | 2009-12-17 | Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US8383659B2 (es) |
| EP (1) | EP2379537B9 (es) |
| JP (1) | JP5608676B2 (es) |
| CN (1) | CN102256971B (es) |
| AR (1) | AR074790A1 (es) |
| AU (1) | AU2009327079B2 (es) |
| BR (1) | BRPI0923009B1 (es) |
| CA (1) | CA2747354C (es) |
| CL (1) | CL2011001390A1 (es) |
| CO (1) | CO6341475A2 (es) |
| DK (1) | DK2379537T5 (es) |
| ES (1) | ES2395704T3 (es) |
| HU (2) | HUE015568T4 (es) |
| LU (1) | LUC00030I2 (es) |
| MX (1) | MX2011006568A (es) |
| NL (1) | NL300891I2 (es) |
| NO (1) | NO2017048I1 (es) |
| NZ (1) | NZ593135A (es) |
| PL (1) | PL2379537T3 (es) |
| PT (1) | PT2379537E (es) |
| RU (1) | RU2518462C2 (es) |
| TW (1) | TWI454472B (es) |
| WO (1) | WO2010070068A2 (es) |
| ZA (1) | ZA201103780B (es) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
| EA021522B9 (ru) | 2009-12-17 | 2016-08-31 | Мериал Лимитед | Противопаразитарные дигидроазоловые соединения и содержащие их композиции |
| UY33403A (es) * | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| CN103270036B (zh) * | 2010-08-05 | 2015-11-25 | 佐蒂斯有限责任公司 | 作为抗寄生物剂的异噁唑啉衍生物 |
| WO2012034961A1 (en) * | 2010-09-13 | 2012-03-22 | Basf Se | Pyridine compounds for controlling invertebrate pests i |
| KR101901466B1 (ko) * | 2010-09-27 | 2018-09-21 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 2-아미노-n-(2,2,2-트라이플루오로에틸)아세트아미드의 제조 방법 |
| KR102027723B1 (ko) | 2010-12-27 | 2019-10-01 | 인터벳 인터내셔널 비.브이. | 국소 적용 이속사졸린 제제 |
| KR101920476B1 (ko) | 2010-12-27 | 2018-11-21 | 인터벳 인터내셔널 비.브이. | 글리코푸롤을 포함하는 국소 적용 이속사졸린 제제 |
| JP2014505089A (ja) * | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | 無脊椎有害動物を防除するためのイソオキサゾリン誘導体 |
| ES2542409T3 (es) * | 2011-03-10 | 2015-08-05 | Novartis Tiergesundheit Ag | Derivados de isoxazol |
| WO2012127347A1 (en) * | 2011-03-22 | 2012-09-27 | Pfizer Inc. | Isoxazoline derivatives as antiparasitic agents |
| AR086113A1 (es) * | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| CN102358725B (zh) * | 2011-11-04 | 2013-08-14 | 重庆博腾制药科技股份有限公司 | 一种异恶唑类化合物的中间体的制备方法 |
| AU2012344083A1 (en) | 2011-11-29 | 2014-05-29 | Novartis Tiergesundheit Ag | Aryl derivatives for controlling ectoparasites |
| UA113753C2 (xx) * | 2012-01-26 | 2017-03-10 | Фенілзаміщені кетоеноли для боротьби з паразитами риб | |
| AU2013215374A1 (en) * | 2012-02-03 | 2014-08-21 | Zoetis Services Llc | Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents |
| ES2720201T3 (es) | 2012-02-06 | 2019-07-18 | Merial Inc | Composiciones parasiticidas orales veterinarias que comprenden agentes activos de acción sistémica y usos de las mismas |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| US20150057321A1 (en) * | 2012-04-04 | 2015-02-26 | Intervet Inc. | Soft chewable pharmaceutical products |
| US9532946B2 (en) | 2012-11-20 | 2017-01-03 | Intervet Inc. | Manufacturing of semi-plastic pharmaceutical dosage units |
| WO2014090918A1 (en) | 2012-12-13 | 2014-06-19 | Novartis Ag | Process for the enantiomeric enrichment of diaryloxazoline derivatives |
| UY35428A (es) | 2013-03-15 | 2014-10-31 | Monsanto Technology Llc | ?azoles n-,c-disustituidos y composiciones y métodos para controlar plagas de nematodos?. |
| BR112015032324B1 (pt) * | 2013-06-24 | 2020-04-07 | Merial Inc | compostos isotiazolina-substituído de tiofeno ou furano como pesticidas |
| US9914740B2 (en) | 2013-07-02 | 2018-03-13 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
| ES2634628T3 (es) | 2013-07-02 | 2017-09-28 | Bristol-Myers Squibb Company | Derivados tricíclicos de pirido-carboxamida como inhibidores ROCK |
| SG11201603430XA (en) | 2013-11-01 | 2016-05-30 | Merial Ltd | Antiparasitic and pesticidal isoxazoline compounds |
| EP3068902B1 (en) | 2013-11-12 | 2018-08-29 | Life Technologies Corporation | System and method for emulsion breaking |
| DK3079474T3 (da) | 2013-12-10 | 2019-09-16 | Intervet Int Bv | Anvendelse af isoxazolinforbindelser mod parasiter |
| HUE072822T2 (hu) | 2013-12-20 | 2025-12-28 | Intervet Int Bv | Izoxazolin kompozíciók és azok felhasználása parazita fertõzések megelõzésében vagy kezelésében állatokban |
| HUE055444T2 (hu) | 2013-12-20 | 2021-11-29 | Intervet Int Bv | Izoxazolinszármazákok felhasználása baromfiak arthropodafertõzéseinek kezelésére vagy megelõzésére |
| AR101816A1 (es) * | 2014-04-02 | 2017-01-18 | Bayer Cropscience Ag | Derivados de 3-[(pirazol-5-il)-heteroaril]-benzamidas como agentes pesticidas |
| AU2015247463B2 (en) | 2014-04-17 | 2018-03-29 | Basf, Se | Use of malononitrile compounds for protecting animals from parasites |
| WO2015191877A1 (en) | 2014-06-11 | 2015-12-17 | Life Technologies Corporation | Systems and methods for substrate enrichment |
| WO2016022066A1 (en) | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| EP3018129A1 (en) | 2014-11-10 | 2016-05-11 | Novartis Tiergesundheit AG | Diaryl isoxazoline compound |
| JP6706262B2 (ja) | 2014-12-22 | 2020-06-03 | インターベット インターナショナル ベー． フェー． | 毛包虫症治療のためのイソオキサゾリン化合物の使用 |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| HK1251972A1 (zh) | 2015-05-06 | 2019-05-10 | The Regents Of The University Of California | K-ras调节剂 |
| SG10202103403SA (en) | 2015-05-20 | 2021-05-28 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic depsipeptide compounds |
| WO2016207234A1 (en) | 2015-06-23 | 2016-12-29 | Intervet International B.V. | Isoxazoline solution containing vitamin e for use with sanitized drinking water |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| HRP20211979T1 (hr) | 2016-04-06 | 2022-04-01 | Boehringer Ingelheim Animal Health USA Inc. | Postupak za pripravu enantiomerno obogaćenih spojeva izoksazolina – kristalnog toluen solvata (s)-afoksolanera |
| CN109328017A (zh) | 2016-05-10 | 2019-02-12 | 瑞士伊兰科动物保健有限公司 | 用于控制海虱的二氢异噁唑化合物 |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| US11382949B2 (en) | 2016-11-16 | 2022-07-12 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| MA50014A (fr) | 2017-04-20 | 2020-07-08 | Leidos Biomedical Res Inc | Modulateurs de k-ras |
| WO2019036407A1 (en) | 2017-08-14 | 2019-02-21 | Merial, Inc. | PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY |
| KR20200044099A (ko) | 2017-09-06 | 2020-04-28 | 바이엘 애니멀 헬스 게엠베하 | 동물 기생충의 방제 및 예방을 위한 국소 투여가능한 제형 |
| PH12020550555B1 (en) | 2017-11-07 | 2024-03-06 | Intervet Int Bv | Injectable isoxazoline pharmaceutical compositions and uses thereof |
| UA127892C2 (uk) | 2017-11-07 | 2024-02-07 | Інтервет Інтернешнл Б.В. | Спосіб одержання частинок ізоксазоліну великого розміру |
| AU2018385363B2 (en) | 2017-12-12 | 2024-06-13 | Intervet International B.V. | Implantable isoxazoline pharmaceutical compositions and uses thereof |
| SI3723739T1 (sl) | 2017-12-15 | 2024-08-30 | Tarsus Pharmaceuticals, Inc. | Paraziticidni pripravki na osnovi izoksazolina in njihova uporaba za zdravljenje blefaritisa |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| EP3749096A1 (en) | 2018-02-08 | 2020-12-16 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| CR20200641A (es) * | 2018-07-05 | 2021-02-16 | Bayer Ag | Tiofenocarboxamidas sustituidas y analogos como agentes antibacterianos |
| IL279977B2 (en) | 2018-07-09 | 2024-06-01 | Boehringer Ingelheim Animal Health Usa Inc | Heterocyclic anthelmintic compounds |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| AU2020208145B2 (en) | 2019-01-16 | 2023-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| CN109879826B (zh) * | 2019-03-18 | 2021-04-13 | 丽珠集团新北江制药股份有限公司 | 一种异噁唑啉类杀虫剂的制备方法 |
| US11560388B2 (en) | 2019-03-19 | 2023-01-24 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| PH12021552713A1 (en) | 2019-05-03 | 2022-07-04 | Intervet Int Bv | Injectable pharmaceutical compositions and uses thereof |
| WO2021013825A1 (en) | 2019-07-22 | 2021-01-28 | Intervet International B.V. | Soft chewable veterinary dosage form |
| AU2020409532A1 (en) | 2019-12-16 | 2022-05-12 | Intervet International B.V. | Composition for lice control |
| MX2022007309A (es) | 2019-12-16 | 2022-07-12 | Intervet Int Bv | Composicion para control de piojos en aves de corral. |
| WO2021122515A1 (en) | 2019-12-16 | 2021-06-24 | Intervet International B.V. | Parasite control in ruminants |
| US12497370B2 (en) | 2019-12-18 | 2025-12-16 | Elanco Tiergesundheit Ag | Isoxazoline derivatives |
| DK4153133T3 (da) | 2020-05-20 | 2024-02-05 | Intervet Int Bv | Injicerbare farmaceutiske sammensætninger og anvendelser deraf |
| CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| AU2021311722A1 (en) | 2020-07-24 | 2023-02-02 | Elanco Us Inc. | Process for making an isoxazoline compound and intermediate thereof |
| CA3209562A1 (en) | 2021-01-27 | 2022-08-04 | Intervet International B.V. | Cyclopropylamide compounds against parasites in fish |
| US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| WO2022258797A1 (en) | 2021-06-11 | 2022-12-15 | Intervet International B.V. | Tick control methods |
| MX2023014965A (es) | 2021-06-16 | 2024-02-13 | Elanco Tiergesundheit Ag | Plaguicidas de (thi)oxazolina. |
| MX2023015272A (es) | 2021-06-16 | 2024-03-19 | Elanco Tiergesundheit Ag | Derivados de isoxazolina. |
| BR112023027372A2 (pt) | 2021-06-25 | 2024-03-12 | Intervet Int Bv | Composições veterinárias palatáveis |
| MX2023014962A (es) | 2021-08-11 | 2024-02-13 | Elanco Us Inc | Proceso para elaborar derivado de diaril isoxazolina. |
| US20250042885A1 (en) | 2021-12-10 | 2025-02-06 | Teva Pharmaceuticals International Gmbh | Solid state forms of lotilaner and process for preparation thereof |
| JP2025507585A (ja) | 2022-02-17 | 2025-03-21 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 流体製品メーラーを提供する方法及びシステム |
| CN114853748A (zh) * | 2022-05-06 | 2022-08-05 | 武汉工程大学 | 一种含三氟甲烷异噁唑啉类衍生物、其制备方法和应用 |
| AU2023332216A1 (en) | 2022-09-02 | 2025-02-20 | Intervet International B.V. | Treatment of fasciolosis |
| DK182016B1 (en) | 2023-03-13 | 2025-05-28 | Zoetis Services Llc | Degradation of isoxazolines in ozonated sea water |
| UA130006C2 (uk) | 2023-08-07 | 2025-10-08 | Юрій Юрійович Синиця | Водорозчинний комплекс афоксоланера, спосіб його отримання та ветеринарні протипаразитарні препарати, що його містять |
| NO20240925A1 (en) | 2023-09-15 | 2025-03-17 | Evah Atlantic Inc | Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish |
| WO2025191150A2 (en) | 2024-03-15 | 2025-09-18 | Krka, D.D., Novo Mesto | Stable isoxazoline formulation for topical application to the skin |
| WO2026006412A1 (en) | 2024-06-25 | 2026-01-02 | Elanco Us Inc. | Isooxazoline compounds as antiparasitic agents |
| WO2026006414A1 (en) | 2024-06-25 | 2026-01-02 | Elanco Us Inc. | Isoxazol-benzamide compounds as antiparasitic compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001158786A (ja) * | 1999-11-30 | 2001-06-12 | Takeda Chem Ind Ltd | 哺乳動物の外部寄生虫防除剤 |
| AU2003261713A1 (en) * | 2002-08-26 | 2004-03-11 | Nissan Chemical Industries, Ltd. | Substituted benzanilide compound and pest control agent |
| DE10331675A1 (de) * | 2003-07-14 | 2005-02-10 | Bayer Cropscience Ag | Hetarylsubstituierte Pyrazolidindion-Derivate |
| DE10337497A1 (de) * | 2003-08-14 | 2005-03-10 | Bayer Cropscience Ag | 4-Biphenylsubstituierte-Pyrazolidin-3,5-dion-Derivate |
| JP2005272452A (ja) * | 2004-02-23 | 2005-10-06 | Nissan Chem Ind Ltd | 置換ベンズアニリド化合物及び有害生物防除剤 |
| AU2006285613B2 (en) * | 2005-09-02 | 2011-11-17 | Nissan Chemical Corporation | Isoxazoline-substituted benzamide compound and harmful organism-controlling agent |
| JP4479917B2 (ja) * | 2005-09-02 | 2010-06-09 | 日産化学工業株式会社 | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
-
2009
- 2009-12-17 PL PL09784092T patent/PL2379537T3/pl unknown
- 2009-12-17 MX MX2011006568A patent/MX2011006568A/es active IP Right Grant
- 2009-12-17 NZ NZ593135A patent/NZ593135A/xx unknown
- 2009-12-17 AR ARP090104966A patent/AR074790A1/es active IP Right Grant
- 2009-12-17 ES ES09784092T patent/ES2395704T3/es active Active
- 2009-12-17 WO PCT/EP2009/067450 patent/WO2010070068A2/en not_active Ceased
- 2009-12-17 CN CN200980151179.8A patent/CN102256971B/zh active Active
- 2009-12-17 CA CA2747354A patent/CA2747354C/en active Active
- 2009-12-17 US US13/133,678 patent/US8383659B2/en active Active
- 2009-12-17 TW TW098143302A patent/TWI454472B/zh active
- 2009-12-17 EP EP09784092.0A patent/EP2379537B9/en active Active
- 2009-12-17 BR BRPI0923009A patent/BRPI0923009B1/pt active IP Right Grant
- 2009-12-17 HU HUE09784092A patent/HUE015568T4/en unknown
- 2009-12-17 AU AU2009327079A patent/AU2009327079B2/en active Active
- 2009-12-17 PT PT97840920T patent/PT2379537E/pt unknown
- 2009-12-17 RU RU2011129555/04A patent/RU2518462C2/ru active
- 2009-12-17 JP JP2011541454A patent/JP5608676B2/ja active Active
- 2009-12-17 DK DK09784092.0T patent/DK2379537T5/en active
-
2011
- 2011-05-24 ZA ZA2011/03780A patent/ZA201103780B/en unknown
- 2011-05-31 CO CO11067380A patent/CO6341475A2/es active IP Right Grant
- 2011-06-08 CL CL2011001390A patent/CL2011001390A1/es unknown
-
2013
- 2013-01-14 US US13/740,756 patent/US8653116B2/en not_active Expired - Fee Related
-
2014
- 2014-01-06 US US14/148,205 patent/US9044389B2/en not_active Expired - Fee Related
-
2017
- 2017-08-09 LU LU00030C patent/LUC00030I2/fr unknown
- 2017-08-29 HU HUS1700034C patent/HUS1700034I1/hu unknown
- 2017-08-31 NL NL300891C patent/NL300891I2/nl unknown
- 2017-09-08 NO NO2017048C patent/NO2017048I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR074790A1 (es) | Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. | |
| AR085354A1 (es) | Derivados de isoxazol para control de pestes invertebrados | |
| AR085657A1 (es) | Compuestos de isoxazol | |
| AR081998A1 (es) | Compuestos de isoxazolinas, composicion para el control de parasitos en base al compuesto, metodo de control de parasitos y uso del compuesto para tal fin | |
| AR116978A1 (es) | Fungicidas de tolilo sustituido | |
| AR072576A1 (es) | Metodo para la represion de malezas en un cesped | |
| AR082519A1 (es) | Fenilamidinas que tienen alta actividad fungicida, y su utilizacion | |
| AR059513A1 (es) | Derivados benzoil - piperidina como moduladores de 5ht/ d3 | |
| AR078163A1 (es) | Utilizacion de aminodihidrotiazinas para el tratamiento o prevencion de la diabetes | |
| AR080596A1 (es) | Compuestos alquilamido y composiciones farmaceuticas | |
| AR069368A1 (es) | Mezclas fungicidas | |
| AR042420A1 (es) | Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica | |
| AR079205A1 (es) | Morfolinotiazoles como moduladores alostericos positivos alfa 7 | |
| AR057705A1 (es) | 3-acilaminobenzanilidas insecticidas | |
| AR054799A1 (es) | Derivados de oxindol | |
| AR072906A1 (es) | Nucleosidos modificados utiles como antivirales | |
| AR058896A1 (es) | Isoxazolinas para controlar plagas de invertebrados | |
| AR070582A1 (es) | Arilpirrolinas insecticidas y procedimiento para prepararlos | |
| AR081577A1 (es) | Derivados de aminopirimidina como moduladores de la lrrk2 | |
| AR044152A1 (es) | Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad | |
| AR074782A1 (es) | Antranilamidas sustituidas con tetrazol como plaguicidas | |
| AR073136A1 (es) | Compuestos de pirrol | |
| AR061667A1 (es) | Arilamidas sustituidas con tetrazol | |
| AR068376A1 (es) | Amidas heterociclicas utiles para inhibir la via hedgehog. | |
| AR085615A1 (es) | Derivados de fluoropiridinona utiles como agentes antibacterianos y composiciones farmaceuticas que los contienen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |