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AR074629A1 - Derivados de 1-bencil-cinolin-4-(1h)-ona sustituidos, su preparacion, composiciones farmaceuticas y su uso en el tratamiento de patologias asociadas con receptores de los cannabinoides cb2 - Google Patents

Derivados de 1-bencil-cinolin-4-(1h)-ona sustituidos, su preparacion, composiciones farmaceuticas y su uso en el tratamiento de patologias asociadas con receptores de los cannabinoides cb2

Info

Publication number
AR074629A1
AR074629A1 ARP090102584A ARP090102584A AR074629A1 AR 074629 A1 AR074629 A1 AR 074629A1 AR P090102584 A ARP090102584 A AR P090102584A AR P090102584 A ARP090102584 A AR P090102584A AR 074629 A1 AR074629 A1 AR 074629A1
Authority
AR
Argentina
Prior art keywords
group
several times
alk
unsubstituted
halogen atom
Prior art date
Application number
ARP090102584A
Other languages
English (en)
Inventor
Pascale Roux
Elodie Barbagallo
Claude Vernhet
Murielle Rinaldi-Carmona
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR074629A1 publication Critical patent/AR074629A1/es

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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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Abstract

Reivindicación 1: Un compuesto que responde a la fórmula (1), en la que: R1 representa: i) un fenilo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halógeno, un grupo Alk, un grupo OAlk, un ciano, un grupo -NHSO2Alk, un grupo -SO2Alk; ii) un naftilo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halógeno, un grupo Alk, un grupo OAlk; iii) un piridilo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halógeno, un grupo Alk, un grupo OAlk; iv) un 1-benzotienilo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halógeno, un grupo Alk, un grupo OAIk; v) un 1,3-benzodioxolilo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halógeno, un grupo Alk, un grupo OAlk; R2 representa un grupo aromático o heteroaromático, estando dicho grupo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halógeno, un grupo Alk, un grupo OAlk, un ciano; R3 representa un átomo de hidrógeno, un átomo de halógeno, un grupo Alk, un grupo OAlk; Alk representa un alquilo C1-4 no sustituido o sustituido una o varias veces con un átomo de flúor; en el estado de base o de sal de adición a un ácido.
ARP090102584A 2008-07-11 2009-07-08 Derivados de 1-bencil-cinolin-4-(1h)-ona sustituidos, su preparacion, composiciones farmaceuticas y su uso en el tratamiento de patologias asociadas con receptores de los cannabinoides cb2 AR074629A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803974A FR2933697B1 (fr) 2008-07-11 2008-07-11 Derives de 1-benzyl-cinnolin-4-(1h)-one substitues, leur preparation et leur application en therapeutique

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FR2944013B1 (fr) * 2009-04-07 2011-07-15 Sanofi Aventis Derives de 1-alkyl-cinnolin-4(1h)-one substitues,leur preparation et leur application en therapeutique.
WO2012020780A1 (ja) * 2010-08-10 2012-02-16 武田薬品工業株式会社 複素環化合物およびその用途
KR101719565B1 (ko) * 2014-10-02 2017-03-24 한국화학연구원 광산화환원 촉매와 CF3SO2Cl을 사용한 알켄 화합물의 클로로트리플루오로메틸레이션 방법

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US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
US5532237A (en) * 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
FR2735774B1 (fr) 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
FR2816938B1 (fr) * 2000-11-22 2003-01-03 Sanofi Synthelabo Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant
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MX2011000441A (es) 2011-04-04
US20110144115A1 (en) 2011-06-16
CA2729896A1 (fr) 2010-01-14
IL210529A0 (en) 2011-03-31
EP2313376B1 (fr) 2014-12-24
TW201002681A (en) 2010-01-16
AU2009269836A1 (en) 2010-01-14
CL2011000045A1 (es) 2011-06-17
MA32543B1 (fr) 2011-08-01
BRPI0915884A2 (pt) 2015-11-03
FR2933697B1 (fr) 2010-08-13
JP2011527323A (ja) 2011-10-27
JP5490113B2 (ja) 2014-05-14
FR2933697A1 (fr) 2010-01-15
CN102149689A (zh) 2011-08-10
NZ590426A (en) 2012-04-27
US8410099B2 (en) 2013-04-02
CO6331466A2 (es) 2011-10-20
EP2313376A2 (fr) 2011-04-27
WO2010004215A3 (fr) 2010-03-04
WO2010004215A2 (fr) 2010-01-14
ZA201100251B (en) 2012-04-25
EA201170183A1 (ru) 2011-08-30
UY31978A (es) 2010-02-26
KR20110036931A (ko) 2011-04-12

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