AR074454A1 - Compuestos 4-(-heterocicloalquil) benceno-1,3-diol como inhibidores de la tirosinasa, y su uso en medicina humana y tambien en cosmetica - Google Patents
Compuestos 4-(-heterocicloalquil) benceno-1,3-diol como inhibidores de la tirosinasa, y su uso en medicina humana y tambien en cosmeticaInfo
- Publication number
- AR074454A1 AR074454A1 ARP090104649A ARP090104649A AR074454A1 AR 074454 A1 AR074454 A1 AR 074454A1 AR P090104649 A ARP090104649 A AR P090104649A AR P090104649 A ARP090104649 A AR P090104649A AR 074454 A1 AR074454 A1 AR 074454A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- diol
- benzene
- heterocicloalquil
- thyrosinase
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000002537 cosmetic Substances 0.000 title abstract 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N o-dihydroxy-benzene Natural products OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 title abstract 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001755 resorcinol Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 C1- alkoxy 4 Chemical group 0.000 abstract 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- 208000012641 Pigmentation disease Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos 4-(heterocicloalquil)bencen-1,3-diol. Composiciones que los contienen y para su uso en composiciones farmacéuticas o cosméticas, para usar en el tratamiento o en la prevención de los trastornos de la pigmentación. Reivindicación 1: Compuestos de fórmula general (1) en la cual R1, R2, R3 y R4, que pueden ser idénticos o diferentes, representan hidrógeno, alquilo C1-4, hidroximetilo, hidroxietilo, alcoxi C1-4-carbonilo, alcoxi C1-4, hidroxilo, o R1 y R2 están unidos entre sí y forman un anillo de C que contiene 5 o 6 átomos de C, con el átomo de C al cual están unidos, y R3 y R4, que pueden ser idénticos o diferentes, representan H, alquilo C1-4, o R1 y R4 est5án unidos entre sí y forman una cadena -(CH2)2- o -(CH2)3- y R2 y R3, que pueden ser idénticos o diferentes, representan H, alquilo C1-4, X representa un átomo de oxígeno o un átomo de azufre, Y representa un H, CL o F; m pude tener el valor 1 o 2, y n puede tener el valor 0 o 1; y cuando n = 0, entonces m = 1 o 2, y cuando n = 1, entonces m = 1, y también las sales de los compuestos de fórmula general (1), y sus formas isoméricas y enantioméricas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0858206A FR2939136B1 (fr) | 2008-12-02 | 2008-12-02 | Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| US20212809P | 2009-01-30 | 2009-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074454A1 true AR074454A1 (es) | 2011-01-19 |
Family
ID=40845880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104649A AR074454A1 (es) | 2008-12-02 | 2009-12-02 | Compuestos 4-(-heterocicloalquil) benceno-1,3-diol como inhibidores de la tirosinasa, y su uso en medicina humana y tambien en cosmetica |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8372879B2 (es) |
| EP (2) | EP2373310B1 (es) |
| JP (1) | JP5395188B2 (es) |
| KR (1) | KR101290504B1 (es) |
| CN (1) | CN102238948B (es) |
| AR (1) | AR074454A1 (es) |
| AU (1) | AU2009324080B2 (es) |
| BR (1) | BRPI0916504B8 (es) |
| CA (1) | CA2742703C (es) |
| DK (1) | DK2373310T3 (es) |
| ES (2) | ES2393916T3 (es) |
| FR (1) | FR2939136B1 (es) |
| HR (1) | HRP20120954T1 (es) |
| MX (1) | MX2011005479A (es) |
| PL (2) | PL2529735T3 (es) |
| PT (1) | PT2373310E (es) |
| RU (1) | RU2482116C2 (es) |
| SI (1) | SI2373310T1 (es) |
| SM (1) | SMT201200057B (es) |
| WO (1) | WO2010063773A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2939135B1 (fr) * | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| PT3290415T (pt) | 2011-03-23 | 2021-03-29 | Trevena Inc | Ligandos de recetores opioides e métodos de utilização e fabrico dos mesmos |
| ES2635290T3 (es) * | 2013-02-14 | 2017-10-03 | Galderma Research & Development | Procedimiento de síntesis de compuestos 4-(heterocicloalquil)-benceno-1,3-diol |
| WO2014139080A1 (en) * | 2013-03-12 | 2014-09-18 | Boehringer Ingelheim International Trading (Shanghai) Co., Ltd. | Novel process for the manufacture of 3-oxo-tetrahydrofuran |
| FR3030249B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un polymere et un glycol |
| FR3030252B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un monoalcool en c2-c4 et un glycol |
| FR3030250B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un hydrotrope |
| FR3030251B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un solvant particulier |
| JP6873598B2 (ja) * | 2015-12-22 | 2021-05-19 | ロレアル | 活性成分のための改善された局所送達系 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0651619B2 (ja) | 1988-05-09 | 1994-07-06 | 株式会社クラレ | 美白剤 |
| FR2704428B1 (fr) | 1993-04-29 | 1995-06-09 | Oreal | Utilisation de dérivés de la résorcine substitués en position(s) 4, 4 et 5 ou 4 et 6 dans des compositions cosmétiques ou dermopharmaceutiques à action dépigmentante. |
| US6068834A (en) * | 1994-03-04 | 2000-05-30 | The Procter & Gamble Company | Skin lightening compositions |
| BR9803596A (pt) * | 1997-09-23 | 2000-04-25 | Pfizer Prod Inc | Derivados do resorcinol. |
| JPH11255637A (ja) * | 1998-03-13 | 1999-09-21 | Kansai Kouso Kk | チロシナーゼ活性阻害剤及び化粧料 |
| HN2000000033A (es) * | 1999-03-22 | 2001-02-02 | Pfizer Prod Inc | Composicion de resorcinol |
| WO2002020434A1 (en) * | 2000-09-07 | 2002-03-14 | Wisconsin Alumni Research Foundation | Synthesis of 17f labeled fluoroalkanes |
| JP3957291B2 (ja) * | 2000-09-11 | 2007-08-15 | ファイザー・プロダクツ・インク | レゾルシノール誘導体 |
| US6852310B2 (en) | 2002-08-23 | 2005-02-08 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
| US6875425B2 (en) * | 2002-12-12 | 2005-04-05 | Unilever Home & Personal Care Usa | Skin lightening agents, compositions and methods |
| US7300646B2 (en) | 2004-02-27 | 2007-11-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
| US20060210498A1 (en) | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives for skin |
| US20060210497A1 (en) | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives |
| FR2917087B1 (fr) * | 2007-06-05 | 2012-09-21 | Galderma Res & Dev | Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique. |
-
2008
- 2008-12-02 FR FR0858206A patent/FR2939136B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-02 AR ARP090104649A patent/AR074454A1/es unknown
- 2009-12-02 KR KR1020117015284A patent/KR101290504B1/ko not_active Expired - Fee Related
- 2009-12-02 PT PT97969901T patent/PT2373310E/pt unknown
- 2009-12-02 MX MX2011005479A patent/MX2011005479A/es active IP Right Grant
- 2009-12-02 HR HRP20120954AT patent/HRP20120954T1/hr unknown
- 2009-12-02 ES ES09796990T patent/ES2393916T3/es active Active
- 2009-12-02 AU AU2009324080A patent/AU2009324080B2/en not_active Ceased
- 2009-12-02 CA CA2742703A patent/CA2742703C/en active Active
- 2009-12-02 JP JP2011538010A patent/JP5395188B2/ja not_active Expired - Fee Related
- 2009-12-02 EP EP09796990A patent/EP2373310B1/en not_active Not-in-force
- 2009-12-02 DK DK09796990.1T patent/DK2373310T3/da active
- 2009-12-02 CN CN200980148286.5A patent/CN102238948B/zh not_active Expired - Fee Related
- 2009-12-02 ES ES12182351.2T patent/ES2506265T3/es active Active
- 2009-12-02 PL PL12182351T patent/PL2529735T3/pl unknown
- 2009-12-02 WO PCT/EP2009/066267 patent/WO2010063773A1/en not_active Ceased
- 2009-12-02 BR BRPI0916504A patent/BRPI0916504B8/pt not_active IP Right Cessation
- 2009-12-02 PL PL09796990T patent/PL2373310T3/pl unknown
- 2009-12-02 RU RU2011127120/04A patent/RU2482116C2/ru active
- 2009-12-02 US US13/131,161 patent/US8372879B2/en not_active Expired - Fee Related
- 2009-12-02 EP EP12182351.2A patent/EP2529735B1/en not_active Not-in-force
- 2009-12-02 SI SI200930399T patent/SI2373310T1/sl unknown
-
2012
- 2012-11-30 SM SM201200057T patent/SMT201200057B/it unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |