AR063881A1 - Compuesto de 2-alquil-indazol, procedimiento de preparacion y composicion farmaceutica que lo contiene - Google Patents
Compuesto de 2-alquil-indazol, procedimiento de preparacion y composicion farmaceutica que lo contieneInfo
- Publication number
- AR063881A1 AR063881A1 ARP070105165A ARP070105165A AR063881A1 AR 063881 A1 AR063881 A1 AR 063881A1 AR P070105165 A ARP070105165 A AR P070105165A AR P070105165 A ARP070105165 A AR P070105165A AR 063881 A1 AR063881 A1 AR 063881A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- halogen
- group
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 9
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 6
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 abstract 3
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- -1 C1-3 alkyl-CO- Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compuesto de 2-alquil-indazol y sus sales de adición de ácido farmacéuticamente aceptables, procedimiento de preparación y una composición farmacéutica que los contiene. Tratamiento de trastornos el SNC, de la musculatura lisa y de los sistemas gastrointestinal y cardiovascular. Reivindicación 1: Compuesto de 2-alquil-indazol de fórmula general (1) en la que X es -C(O)N(R5)- o -N(R5)C(O)-; Y es CH o N; W es CH o N; con la condición de que por lo menos uno entre Y y W es un átomo de N; n es un número entero seleccionado de entre 0, 1, 2 y 3; m es un número entero seleccionado de entre 0, 1, 2 y 3; p es un número entero seleccionado de entre 0, 1 y 2; R1 es H, alquilo C1-3, alcoxi C1-3, alquil C1-3-CO-, COOH, R'R"NCO-, R'R"NSO2-, R'SO2-, halógeno, R'R"N'- o R'CON(R")-; R2 es alquilo C1-6 lineal o ramificado, alquilo C1-3-alcoxi C1-3, aril-alquilo C1-3 en el que el grupo arilo puede estar sustituido con 1 o 2 sustituyentes seleccionados de entre halógeno, alquilo C1-3 y alcoxi C1-3; R3 y R4, que pueden ser iguales o diferentes, son H, hidroxi, alquilo C1-3, alcoxi C1-3, R'R"N-, nitro, halógeno, trifluorometilo o R'CON(R")-; R5 es H, alquilo C1-3, alcoxi C1-3, o, junto con R6, forma un anillo saturado de 5 o 6 miembros seleccionados de entre el grupo que comprende pirrolidina, imidazolina, pirazolidina, piperidina y piperazina; R6, junto con R5 o R7, forma un anillo saturado de 5 o 6 miembros seleccionados de entre el grupo que comprende pirrolidina, imidazolina, pirazolidina, piperidina y piperazina, R7 es H, alquilo C1-6 lineal o ramificado, aril-alquilo C1-3, en el que el grupo arilo puede estar sustituido con 1 o 2 sustituyentes seleccionados de entre halógeno, alquilo C1-3, hidroxi, alcoxi C1-3, nitro, trifluorometilo y R'R"N-, o R7 junto con R6, forma un anillo saturado de 5 o 6 miembros seleccionados de entre el grupo que comprende pirrolidina, imidazolina, pirazolidina, piperidina y piperazina; R' y R", que pueden ser iguales o diferentes, son H o alquilo C1-3; y sus sales de adición con ácidos orgánicos e inorgánicos farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002230A ITMI20062230A1 (it) | 2006-11-22 | 2006-11-22 | Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063881A1 true AR063881A1 (es) | 2009-02-25 |
Family
ID=38474157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105165A AR063881A1 (es) | 2006-11-22 | 2007-11-21 | Compuesto de 2-alquil-indazol, procedimiento de preparacion y composicion farmaceutica que lo contiene |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8507528B2 (es) |
| EP (1) | EP2099780B1 (es) |
| JP (1) | JP5551443B2 (es) |
| KR (1) | KR101471987B1 (es) |
| CN (1) | CN101558057B (es) |
| AR (1) | AR063881A1 (es) |
| AU (1) | AU2007323368B2 (es) |
| BR (1) | BRPI0718976A2 (es) |
| CA (1) | CA2668205C (es) |
| DK (1) | DK2099780T3 (es) |
| EA (1) | EA019217B1 (es) |
| ES (1) | ES2401199T3 (es) |
| GE (1) | GEP20125414B (es) |
| IL (1) | IL198432A (es) |
| IT (1) | ITMI20062230A1 (es) |
| MX (1) | MX2009005250A (es) |
| PL (1) | PL2099780T3 (es) |
| PT (1) | PT2099780E (es) |
| SG (1) | SG176504A1 (es) |
| SI (1) | SI2099780T1 (es) |
| UA (1) | UA98311C2 (es) |
| WO (1) | WO2008061688A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS53859B1 (sr) | 2010-04-08 | 2015-08-31 | Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. | Triciklično jedinjenje indazola, postupak njegovog dobijanja i farmaceutska kompozicija koja ga sadrži |
| AU2012230503B2 (en) | 2011-03-18 | 2016-07-07 | Bayer Intellectual Property Gmbh | N-(3-carbamoylphenyl)-1H-pyrazole-5-carboxamide derivatives and the use thereof for controlling animal pests |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57501378A (es) * | 1980-09-05 | 1982-08-05 | ||
| GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
| DE3650772T2 (de) | 1985-04-27 | 2003-04-03 | F. Hoffmann-La Roche Ag, Basel | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| JPH02215779A (ja) * | 1989-02-14 | 1990-08-28 | Kuraray Co Ltd | カルボン酸アミド誘導体類及びその医薬用途 |
| US5246947A (en) * | 1991-09-23 | 1993-09-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression |
| AU4949293A (en) | 1992-08-28 | 1994-03-29 | Ciba-Geigy Ag | Indazole derivatives |
| JPH08277287A (ja) | 1995-02-09 | 1996-10-22 | Mitsubishi Chem Corp | インダゾール類およびその用途 |
| EP0829474B1 (en) * | 1995-05-31 | 2003-04-09 | Nisshin Seifun Group Inc. | Indazole derivatives having monocyclic amino group |
| IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| US6218390B1 (en) * | 1998-12-17 | 2001-04-17 | Synaptic Pharmaceutical Corporation | Morpholinone and morpholine derivatives and uses thereof |
| WO2004050634A1 (en) | 2002-12-02 | 2004-06-17 | F. Hoffmann-La Roche Ag | Indazole derivatives as crf antagonists |
| ITMI20030972A1 (it) | 2003-05-15 | 2004-11-16 | Acraf | Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende. |
| ITMI20031468A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco ativo nel dolore neuropatico |
| FR2857966A1 (fr) * | 2003-07-24 | 2005-01-28 | Aventis Pharma Sa | Produits aryl-heteroaromatiques, compositions les contenant et utilisation |
| DK1701951T3 (da) * | 2003-12-23 | 2010-06-07 | Serodus As | Modulatorer af perifere 5-HT receptorer |
| WO2005066163A2 (en) * | 2004-01-05 | 2005-07-21 | Astrazeneca Ab | Thiophene derivatives as chk 1 inihibitors |
| AU2005271737A1 (en) * | 2004-08-03 | 2006-02-16 | Wyeth | Indazoles useful in treating cardiovascular diseases |
| TW200621237A (en) * | 2004-11-01 | 2006-07-01 | Wyeth Corp | [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones |
| SA05260357B1 (ar) * | 2004-11-19 | 2008-09-08 | ارينا فارماسيتو تيكالز ، أنك | مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به |
| WO2008054748A2 (en) * | 2006-10-31 | 2008-05-08 | Arena Pharmaceuticals, Inc. | Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
-
2006
- 2006-11-22 IT IT002230A patent/ITMI20062230A1/it unknown
-
2007
- 2007-11-19 CN CN2007800433966A patent/CN101558057B/zh not_active Expired - Fee Related
- 2007-11-19 US US12/516,091 patent/US8507528B2/en not_active Expired - Fee Related
- 2007-11-19 AU AU2007323368A patent/AU2007323368B2/en not_active Ceased
- 2007-11-19 GE GEAP200711320A patent/GEP20125414B/en unknown
- 2007-11-19 KR KR1020097012960A patent/KR101471987B1/ko not_active Expired - Fee Related
- 2007-11-19 JP JP2009537521A patent/JP5551443B2/ja not_active Expired - Fee Related
- 2007-11-19 ES ES07846673T patent/ES2401199T3/es active Active
- 2007-11-19 WO PCT/EP2007/010000 patent/WO2008061688A1/en not_active Ceased
- 2007-11-19 BR BRPI0718976-1A patent/BRPI0718976A2/pt not_active Application Discontinuation
- 2007-11-19 DK DK07846673.7T patent/DK2099780T3/da active
- 2007-11-19 EP EP07846673A patent/EP2099780B1/en not_active Not-in-force
- 2007-11-19 PL PL07846673T patent/PL2099780T3/pl unknown
- 2007-11-19 UA UAA200905092A patent/UA98311C2/ru unknown
- 2007-11-19 PT PT78466737T patent/PT2099780E/pt unknown
- 2007-11-19 SI SI200731154T patent/SI2099780T1/sl unknown
- 2007-11-19 CA CA2668205A patent/CA2668205C/en not_active Expired - Fee Related
- 2007-11-19 SG SG2011085891A patent/SG176504A1/en unknown
- 2007-11-19 EA EA200970496A patent/EA019217B1/ru not_active IP Right Cessation
- 2007-11-19 MX MX2009005250A patent/MX2009005250A/es active IP Right Grant
- 2007-11-21 AR ARP070105165A patent/AR063881A1/es not_active Application Discontinuation
-
2009
- 2009-04-28 IL IL198432A patent/IL198432A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN101558057B (zh) | 2013-05-01 |
| UA98311C2 (ru) | 2012-05-10 |
| HK1129112A1 (en) | 2009-11-20 |
| AU2007323368B2 (en) | 2013-02-07 |
| PT2099780E (pt) | 2013-03-11 |
| CA2668205A1 (en) | 2008-05-29 |
| KR101471987B1 (ko) | 2014-12-12 |
| SI2099780T1 (sl) | 2013-03-29 |
| GEP20125414B (en) | 2012-03-12 |
| DK2099780T3 (da) | 2013-04-15 |
| US20100056573A1 (en) | 2010-03-04 |
| JP2010510265A (ja) | 2010-04-02 |
| PL2099780T3 (pl) | 2013-05-31 |
| EP2099780A1 (en) | 2009-09-16 |
| EA019217B1 (ru) | 2014-02-28 |
| MX2009005250A (es) | 2009-05-28 |
| KR20090089880A (ko) | 2009-08-24 |
| WO2008061688A1 (en) | 2008-05-29 |
| US8507528B2 (en) | 2013-08-13 |
| SG176504A1 (en) | 2011-12-29 |
| CA2668205C (en) | 2014-10-21 |
| ES2401199T3 (es) | 2013-04-17 |
| BRPI0718976A2 (pt) | 2014-02-04 |
| ITMI20062230A1 (it) | 2008-05-23 |
| JP5551443B2 (ja) | 2014-07-16 |
| AU2007323368A1 (en) | 2008-05-29 |
| IL198432A (en) | 2013-03-24 |
| IL198432A0 (en) | 2010-02-17 |
| EA200970496A1 (ru) | 2009-10-30 |
| CN101558057A (zh) | 2009-10-14 |
| EP2099780B1 (en) | 2013-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |