AR062695A1 - N-(1- ftalazin -1--il- piperidin -4-il) - amidas como moduladores del receptor ep2 - Google Patents
N-(1- ftalazin -1--il- piperidin -4-il) - amidas como moduladores del receptor ep2Info
- Publication number
- AR062695A1 AR062695A1 ARP070103952A ARP070103952A AR062695A1 AR 062695 A1 AR062695 A1 AR 062695A1 AR P070103952 A ARP070103952 A AR P070103952A AR P070103952 A ARP070103952 A AR P070103952A AR 062695 A1 AR062695 A1 AR 062695A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- eventually
- aryl
- ring
- heteroaryl
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002950 monocyclic group Chemical group 0.000 abstract 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- RIVSBJGECJRSQR-UHFFFAOYSA-N N-piperidin-4-ylphthalazin-1-amine Chemical class C1CNCCC1NC1=NN=CC2=CC=CC=C12 RIVSBJGECJRSQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a ftalazin-1-il-piperidin-4-il-amidas de la formula general 1, a procedimientos para su preparacion, así como a su uso para la preparacion de agentes farmacéuticos para el tratamiento de enfermedades e indicaciones que están relacionadas con el receptor EP2. Reivindicacion 1: Compuestos de la formula general 1 en donde W es un hidrogeno o un grupo alquilo C1-4, X es un grupo (CH2)n, en donde n = 0-4, alquenilo C2-4, alquinilo C2-4, R1 es un anillo arilo o heteroarilo mono- o bicíclico de 5-12 miembros, un anillo O-arilo u O-heteroarilo, S-arilo o S-heteroarilo, N-arilo o N-heteroarilo mono- o bicíclico de 5-12 miembros, en donde los anillos pueden no estar sustituidos o eventualmente pueden estar mono- a trisustituidos, un grupo alquilo C1-6, que no está sustituido o que eventualmente está sustituido, un radical cicloalquilo C3-10, que puede no estar sustituido o que eventualmente puede estar sustituido, un radical (hetero)aril-cicloalquilo condensado de 8-12 miembros, que no está sustituido o que eventualmente está sustituido, R2 - R5 son, de modo independiente entre sí, un hidrogeno, halogeno, ciano, o un grupo OR6, OC(O)R6, S(O)nR6, en donde n = 0, 1, 2, SO2NHR6, SO2NHC(O)R6, NR6R7, NHC(O)R6, CH2NR6R7, CH2NHC(O)R6, C(OH)R6R7, C(O)R6, CO2R6, C(O)NR6R7, alquilo C1-6, que puede no estar sustituido o que eventualmente puede estar sustituido, un anillo cicloalquilo C3-10, que puede no estar sustituido o que eventualmente puede estar sustituido, alquenilo C2-6 o alquinilo C2-6 que puede no estar sustituido o que eventualmente puede estar sustituido, un anillo arilo o heteroarilo mono- o bicíclico de 5-12 miembros, que puede no estar sustituido o que eventualmente puede estar sustituido, R6, R7 son un hidrogeno, alquilo C1-6, un anillo cicloalquilo C3-10, un anillo arilo o heteroarilo mono- o bicíclico de 5-12 miembros, en donde los grupos alquilo, cicloalquilo y (het)arilo pueden no estar sustituidos o eventualmente pueden estar sustituidos, o R6, R7 forman juntos un anillo de 3-8 miembros, así como sus isomeros, sales y clatratos de ciclodextrina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090159A EP1900731A1 (de) | 2006-09-07 | 2006-09-07 | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062695A1 true AR062695A1 (es) | 2008-11-26 |
Family
ID=37649444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103952A AR062695A1 (es) | 2006-09-07 | 2007-09-07 | N-(1- ftalazin -1--il- piperidin -4-il) - amidas como moduladores del receptor ep2 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080146576A1 (es) |
| EP (1) | EP1900731A1 (es) |
| AR (1) | AR062695A1 (es) |
| CL (1) | CL2007002578A1 (es) |
| TW (1) | TW200817356A (es) |
| UY (1) | UY30572A1 (es) |
| WO (1) | WO2008028689A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010011948A (es) | 2008-04-29 | 2010-12-14 | Lilly Co Eli | Antagonistas de la trayectoria hedgehog de ftalazina disustituida. |
| EP2149552A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| EP2149554A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Indolylamide als Modulatoren des EP2-Rezeptors |
| EP2149551A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors |
| US8404687B2 (en) | 2008-11-03 | 2013-03-26 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
| ES2392759T3 (es) | 2008-11-17 | 2012-12-13 | Eli Lilly And Company | Piridazina tetrasustituida como antagonistas de la vía Hedgehog. |
| ES2446307T3 (es) | 2008-11-17 | 2014-03-07 | Eli Lilly And Company | Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
| US8883791B2 (en) | 2010-09-29 | 2014-11-11 | Intervet Inc. | N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases |
| EP2621903B1 (en) | 2010-09-29 | 2017-03-01 | Intervet International B.V. | N-heteroaryl compounds |
| BR112013008374A2 (pt) | 2010-10-05 | 2016-06-14 | Purdue Pharma Lp | composto de quinazolina como bloqueador do canal de sódio |
| TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑 |
| AU2013241853B2 (en) | 2012-03-28 | 2017-11-09 | Intervet International B.V. | Heteroaryl compounds with A-cyclic bridging unit |
| US9260441B2 (en) | 2012-03-28 | 2016-02-16 | Intervet Inc. | Heteroaryl compounds with cyclic bridging unit |
| GB201309508D0 (en) * | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| EP3626717A1 (en) | 2013-10-14 | 2020-03-25 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| KR102365952B1 (ko) | 2013-10-14 | 2022-02-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 선택적으로 치환된 퀴놀린 화합물 |
| KR20230107568A (ko) | 2020-10-13 | 2023-07-17 | 엔데버 바이오메디신스, 인크. | 섬유증 치료 방법 |
| US12447148B2 (en) | 2024-03-05 | 2025-10-21 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN148482B (es) * | 1977-06-03 | 1981-03-07 | Pfizer | |
| US4370328A (en) * | 1977-11-03 | 1983-01-25 | Pfizer Inc. | Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines |
| EP1467738A1 (en) * | 2001-10-08 | 2004-10-20 | Medical Research Council | Use of prostaglandin e synthase inhibitors, or ep2 or ep4 receptor antagonists, in the treatment of a pathological condition of the uterus |
-
2006
- 2006-09-07 EP EP06090159A patent/EP1900731A1/de not_active Withdrawn
-
2007
- 2007-09-04 TW TW096132921A patent/TW200817356A/zh unknown
- 2007-09-05 CL CL200702578A patent/CL2007002578A1/es unknown
- 2007-09-05 UY UY30572A patent/UY30572A1/es not_active Application Discontinuation
- 2007-09-06 WO PCT/EP2007/008081 patent/WO2008028689A1/en not_active Ceased
- 2007-09-06 US US11/896,923 patent/US20080146576A1/en not_active Abandoned
- 2007-09-07 AR ARP070103952A patent/AR062695A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008028689A1 (en) | 2008-03-13 |
| CL2007002578A1 (es) | 2008-07-04 |
| EP1900731A1 (de) | 2008-03-19 |
| UY30572A1 (es) | 2008-05-02 |
| TW200817356A (en) | 2008-04-16 |
| US20080146576A1 (en) | 2008-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |