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AR062485A1 - Proceso para la preparacion de una sal de sodio de ibuprofeno de diferentes tamanos de particula - Google Patents

Proceso para la preparacion de una sal de sodio de ibuprofeno de diferentes tamanos de particula

Info

Publication number
AR062485A1
AR062485A1 ARP070103730A ARP070103730A AR062485A1 AR 062485 A1 AR062485 A1 AR 062485A1 AR P070103730 A ARP070103730 A AR P070103730A AR P070103730 A ARP070103730 A AR P070103730A AR 062485 A1 AR062485 A1 AR 062485A1
Authority
AR
Argentina
Prior art keywords
sodium salt
ibuprofen
addition
naoh
particulate
Prior art date
Application number
ARP070103730A
Other languages
English (en)
Original Assignee
Albemarle Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38658432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR062485(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Albemarle Corp filed Critical Albemarle Corp
Publication of AR062485A1 publication Critical patent/AR062485A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporciona una sal sodica de ibuprofeno hidratada fluida de tamano de partícula medio y contenido de agua controlado. Se puede producir agregando NaOH acuoso a una solucion o suspension de ibuprofeno sin hervir en un solvente orgánico que se puede destilar junto con agua a una temperatura en el rango comprendido entre 50 y 120°C. La velocidad de adicion del NaOH es tal que no hace que la mezcla de reaccion resultante hierva antes de completada la adicion. Luego de completada la adicion, el agua se elimina con parte del solvente orgánico por destilacion. Luego de enfriada, la sal sodica de ibuprofeno hidratada se recupera de la suspension resultante. El proceso permite controlar el tamano de partícula medio de la sal sodica de ibuprofeno formada mediante la seleccion y el uso de una concentracion efectiva predeterminada de NaOH en la solucion acuosa de NaOH usada.
ARP070103730A 2006-08-22 2007-08-22 Proceso para la preparacion de una sal de sodio de ibuprofeno de diferentes tamanos de particula AR062485A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83933806P 2006-08-22 2006-08-22

Publications (1)

Publication Number Publication Date
AR062485A1 true AR062485A1 (es) 2008-11-12

Family

ID=38658432

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103730A AR062485A1 (es) 2006-08-22 2007-08-22 Proceso para la preparacion de una sal de sodio de ibuprofeno de diferentes tamanos de particula

Country Status (9)

Country Link
US (1) US20090305041A1 (es)
EP (1) EP2054367B1 (es)
AR (1) AR062485A1 (es)
BR (1) BRPI0716042A2 (es)
CA (1) CA2659865A1 (es)
CL (1) CL2007002425A1 (es)
ES (1) ES2625931T3 (es)
MX (1) MX2009001524A (es)
WO (1) WO2008024820A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002425A1 (es) 2006-08-22 2008-06-27 Albermarle Corp Procedimiento de preparacion controlado de sal sodica de ibuprofeno de tamano de particula mediano; y dichas particulas de sal sodica.
GB0807919D0 (es) 2008-05-01 2008-06-04 Moorlodge Biotech Ventures Ltd
CA2767773C (en) 2011-02-11 2015-11-24 Grain Processing Corporation Composition comprising a salt and a crystallization interrupter
CN102336650B (zh) * 2011-07-19 2013-12-11 青岛科技大学 脱除布洛芬钠盐中有机杂质的汽提工艺与装置
CN103880650B (zh) * 2012-12-19 2016-03-02 山东新华制药股份有限公司 一种布洛芬钠盐精制装置及工艺
CN111807949B (zh) * 2020-07-23 2022-02-11 青岛科技大学 一种从布洛芬钠盐母液中回收布洛芬钠盐的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US4189596A (en) * 1976-05-24 1980-02-19 The Upjohn Company Preparing 2-arylalkanoic acid derivatives
US4145440A (en) * 1977-08-18 1979-03-20 The Upjohn Company Liquid suspension of an aluminum salt of ibuprofen
US4282252A (en) * 1980-05-15 1981-08-04 Thomas Jefferson University Method of increasing coronary blood flow with ibuprofen
US4346108A (en) * 1981-06-22 1982-08-24 The Upjohn Manufacturing Company M Method for preventing adhesion formation
US4447451A (en) * 1981-07-20 1984-05-08 The Upjohn Manufacturing Company M Treatment of adult respiratory distress syndrome
US4404210A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and ibuprofen
US4623736A (en) * 1982-07-09 1986-11-18 The Upjohn Company Arylalkanoic acid process improvement
US4447443A (en) * 1982-11-15 1984-05-08 Merck & Co., Inc. Anti-inflammatory/analgesic combination of α-fluoromethylhistidine and a selected non-steroidal anti-inflammatory drug (NSAID)
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4439450A (en) * 1983-06-30 1984-03-27 The Upjohn Manufacturing Company M Treatment of the blood-brain barrier with ibuprofen
US4558051A (en) * 1983-10-11 1985-12-10 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4552899A (en) * 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4569937A (en) * 1985-02-11 1986-02-11 E. I. Du Pont De Nemours And Company Analgesic mixture of oxycodone and ibuprofen
GB8528195D0 (en) * 1985-11-15 1985-12-18 Boots Co Plc Therapeutic compositions
US4861797A (en) * 1987-10-15 1989-08-29 Oratech Pharmaceutical Development Corporation Liquid ibuprofen compositions and methods of making them
US4859704A (en) * 1987-10-15 1989-08-22 Oratech Pharmaceutical Development Corporation Water soluble ibuprofen compositions and methods of making them
DK0584108T3 (da) 1991-05-13 2000-10-09 Boots Co Plc Farmaceutisk præparat omfattende ibuprofensalt
US5256816A (en) 1992-10-14 1993-10-26 Ethyl Corporation Enantiomeric resolution
US5260482A (en) 1992-10-14 1993-11-09 Ethyl Corporation Enantiomeric resolution
GB9224021D0 (en) 1992-11-16 1993-01-06 Boots Co Plc Effervescent compositions
DE19624607A1 (de) * 1996-06-20 1998-01-02 Basf Ag Verfahren zur Herstellung von Salzen von Säuregruppen tragenden pharmazeutischen Wirkstoffen
CH693586A8 (de) * 2002-10-14 2003-12-15 Roche Consumer Health Ag Darreichungsform von Ibuprofen-Natrium.
CL2007002425A1 (es) 2006-08-22 2008-06-27 Albermarle Corp Procedimiento de preparacion controlado de sal sodica de ibuprofeno de tamano de particula mediano; y dichas particulas de sal sodica.

Also Published As

Publication number Publication date
US20090305041A1 (en) 2009-12-10
ES2625931T3 (es) 2017-07-21
EP2054367B1 (en) 2017-03-22
MX2009001524A (es) 2009-02-18
CA2659865A1 (en) 2008-02-28
BRPI0716042A2 (pt) 2013-09-17
EP2054367A2 (en) 2009-05-06
WO2008024820A3 (en) 2008-05-02
WO2008024820A2 (en) 2008-02-28
CL2007002425A1 (es) 2008-06-27

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