AR060049A1 - MODULATING COMPOUNDS OF THE S1P RECEIVER AND USE OF THE SAME - Google Patents

Abstract

Claim 1: A compound characterized in that it responds to formula (1) wherein A is an optionally substituted aryl or heteroaryl group; B and C are an at least partially aromatic bicyclic ring system; X is selected from the group consisting of WC (O) OR6a, WP (O) R6bR6c, WS (O) 2OH, WCONHSO3H or 1H-tetrazol-5-yl; when W is a direct bond, oxygen or C1-4 alkyl with one or more substituents independently selected from the group consisting of halogen, hydroxyl, cyano, amino, alkylamino, arylamino, heteroarylamino, C1-4 alkoxy and COO2H groups; R6a is hydrogen or C1-4 alkyl; and R6b and R6c are independently hydrogen, hydroxyl, C1-4 alkyl or C1-4 alkyl substituted with halogen; Y is a residue of formula (2) where the left and right asterisks indicate the junction point, where Q is selected from the group consisting of direct bond, C = O, C = S, SO2, C = ONR or ( CR10R11) m; m is 0, 1, 2 or 3; R7 and R8 are independently selected from the group consisting of hydrogen, halogen, amino, C1-5 alkyl, hydroxy, cyano, C1-6 alkyl, hydroxy C1-6 alkyl (eg, hydroxy terminated alkyl), C1 alkylthio -5, C1-5 alkoxy, C1-6 alkyl substituted with halogen and C1-5 alkoxy substituted with halogen; or R7 and R8 can bind to the atoms to which they are attached to form a 4- to 7-membered ring, which optionally has a heteroatom; and R9 is selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, C1-6 alkyl, C1-5 alkylthio, C1-5 alkoxy, halogen substituted C1-6 alkyl or halogen substituted C1-5 alkoxy; R10 and R11 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, C1-6 alkyl, C1-5 alkoxy, C1-5 alkylthio, C1-6 alkyl substituted with halogen or C1-5 alkoxy substituted with halogen; and Z1 and Z2 are independently selected from the group consisting of O, NR3, S, S (O), S (O) 2, S (O) 2NR3, (CR4R5) n, C = O, C = S , C = N-R3, or a direct bond, where R3 is selected from the group consisting of hydrogen, hydroxyl, SO2, C = O, C = S, C = NH, C1-6 alkyl, C1-5 alkoxy, C1-5 alkylthio, C1-6 alkyl substituted by halogen and C1-5 alkoxy substituted by halogen; aryl or heteroaryl, or when Z2 is a direct bond, R3 is a C3-6 ring optionally containing a heteroatom; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, C1-6 alkyl, C1-5 alkoxy, C1-5 alkylthio, C1-6 alkyl substituted with halogen and C1-5 alkoxy substituted with halogen; aryl or heteroaryl or together form C = O; and n is 0, 1, 2 or 3; and R1 is selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C1-5 alkoxy, C1-5amino alkyl, aryl or heteroaryl.