AR069028A1 - Derivados de 1,2,4-triazol pirrolidina fusionados como moduladores de mglur5 - Google Patents
Derivados de 1,2,4-triazol pirrolidina fusionados como moduladores de mglur5Info
- Publication number
- AR069028A1 AR069028A1 ARP080104649A ARP080104649A AR069028A1 AR 069028 A1 AR069028 A1 AR 069028A1 AR P080104649 A ARP080104649 A AR P080104649A AR P080104649 A ARP080104649 A AR P080104649A AR 069028 A1 AR069028 A1 AR 069028A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- alkyl
- mglur5
- triazol
- modulators
- Prior art date
Links
- -1 1,2,4-TRIAZOL PIRROLIDINE DERIVATIVES Chemical class 0.000 title 1
- 101150087728 Grm5 gene Proteins 0.000 title 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un proceso para su preparación y composiciones farmacéuticas que comprenden los compuestos. Reivindicación 1: Un compuesto de fórmula (1) donde: R¹ es metil, halógeno o ciano; R² es hidrógeno o fluoro; R³ es hidrógeno, alquil C₁₋₃, alcoxi C₁₋₃, OR⁵ o NR⁵R⁶; R⁴ es alquil C₁₋₃ o ciclopropil; R⁵ es hidrógeno o alquil C₁₋₃; R⁶ es hidrógeno o alquil C₁₋₃; X es seleccionado del grupo de formulas (2); Y es pirrolidina fusionada con cicloalquil C₃₋₅; Z es un resto del grupo de formulas (3) donde: R⁷ es hidrógeno, alquil C₁₋₃ o alcoxi C₁₋₃; R⁸ es hidrógeno, alquilo C₁₋₃, alcoxi C₁₋₃; R⁹ es hidrógeno, CONR¹⁰R¹¹ o NR¹⁰R¹¹; R¹⁰ es hidrógeno o alquil C₁₋₃; R¹¹ es hidrógeno o alquil C₁₋₃; así como sales, hidratos, isoformas, tautómeros y/o enantiómeros de los mismos farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98297007P | 2007-10-26 | 2007-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069028A1 true AR069028A1 (es) | 2009-12-23 |
Family
ID=40579776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104649A AR069028A1 (es) | 2007-10-26 | 2008-10-24 | Derivados de 1,2,4-triazol pirrolidina fusionados como moduladores de mglur5 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090111820A1 (es) |
| AR (1) | AR069028A1 (es) |
| CL (1) | CL2008003183A1 (es) |
| TW (1) | TW200924774A (es) |
| WO (1) | WO2009054791A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103467362A (zh) * | 2013-09-09 | 2013-12-25 | 嘉兴学院 | 具有环丙烷结构s-二苯基脯氨醇类手性有机小分子化合物及其合成方法 |
| CN103450073A (zh) * | 2013-09-09 | 2013-12-18 | 嘉兴学院 | 具有环丙烷结构r-二苯基脯氨醇类手性有机小分子化合物及其合成方法 |
| CN103435533A (zh) * | 2013-09-09 | 2013-12-11 | 嘉兴学院 | 具有环丙烷结构的s-脯氨醇手性有机小分子化合物及其合成方法 |
| CN103450074A (zh) * | 2013-09-09 | 2013-12-18 | 嘉兴学院 | 具有环丙烷结构的r-脯氨醇手性有机小分子化合物及其合成方法 |
| EP2857387A1 (en) | 2013-10-07 | 2015-04-08 | Boehringer Ingelheim International Gmbh | Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid |
| US11512067B2 (en) * | 2017-09-14 | 2022-11-29 | Daiichi Sankyo Company, Limited | Compound having cyclic structure |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2324044T3 (es) * | 2003-10-08 | 2009-07-29 | Eli Lilly And Company | Derivados de pirrol y pirazol como potenciadores de los receptores de glutamato. |
| SG149900A1 (en) * | 2004-02-18 | 2009-02-27 | Astrazeneca Ab | Polyheterocyclic compounds and their use as metabotropic glutamate receptor antagonists |
| JP2007523183A (ja) * | 2004-02-18 | 2007-08-16 | アストラゼネカ アクチボラグ | 縮合複素環式化合物及び代謝調節型グルタミン酸受容体アンタゴニストとしてのその使用 |
| EP1809620B1 (en) * | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| PT2000465E (pt) * | 2006-03-24 | 2011-02-10 | Eisai R&D Man Co Ltd | Derivado de triazolona |
| TW200811179A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators VI |
| TW200808800A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGluR5 modulators V |
| TW200811157A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators I |
| TW200811137A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators II |
| TW200811156A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators IV |
| TW200808777A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGLUR5 modulators III |
| US7774334B2 (en) * | 2006-11-27 | 2010-08-10 | Sony Ericsson Mobile Communications Ab | Adaptive databases |
| ES2439246T3 (es) * | 2006-12-20 | 2014-01-22 | Merck Sharp & Dohme Corp. | Procedimiento de preparación de (1R,2S,5S)-N-[(1S)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[(2S)-2-[[[(1,1-dimetiletil)amino]carbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3.1.0]hexan-2-carboxamida |
| US8202856B2 (en) * | 2007-12-21 | 2012-06-19 | Merck Serono Sa | Triazole oxadiazoles derivatives |
| WO2009115486A1 (en) * | 2008-03-18 | 2009-09-24 | Glaxo Group Limited | Triazole amide derivatives for use in therapy |
| GB0814954D0 (en) * | 2008-08-18 | 2008-09-24 | Oled T Ltd | Compounds having electron transport properties and their preparation and use |
| ES2561181T3 (es) * | 2009-02-05 | 2016-02-24 | Takeda Pharmaceutical Company Limited | Compuestos de piridazinona |
| US20110045101A1 (en) * | 2009-05-06 | 2011-02-24 | E.I. Du Pont De Nemours And Company | Fungicidal substituted azoles |
-
2008
- 2008-10-23 TW TW097140707A patent/TW200924774A/zh unknown
- 2008-10-23 WO PCT/SE2008/051194 patent/WO2009054791A1/en not_active Ceased
- 2008-10-24 US US12/258,110 patent/US20090111820A1/en not_active Abandoned
- 2008-10-24 CL CL2008003183A patent/CL2008003183A1/es unknown
- 2008-10-24 AR ARP080104649A patent/AR069028A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009054791A1 (en) | 2009-04-30 |
| US20090111820A1 (en) | 2009-04-30 |
| CL2008003183A1 (es) | 2010-01-04 |
| TW200924774A (en) | 2009-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |