AR067927A1 - Quinolinas sustituidas, composiciones y combinaciones que las comprenden y el uso de las mismas en la preparacion de un medicamento para tratamiento de enfermedades inflamatorias y/o alergicas del tracto respiratorio. - Google Patents
Quinolinas sustituidas, composiciones y combinaciones que las comprenden y el uso de las mismas en la preparacion de un medicamento para tratamiento de enfermedades inflamatorias y/o alergicas del tracto respiratorio.Info
- Publication number
- AR067927A1 AR067927A1 ARP080103529A ARP080103529A AR067927A1 AR 067927 A1 AR067927 A1 AR 067927A1 AR P080103529 A ARP080103529 A AR P080103529A AR P080103529 A ARP080103529 A AR P080103529A AR 067927 A1 AR067927 A1 AR 067927A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- compositions
- treatment
- group
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000172 allergic effect Effects 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 210000002345 respiratory system Anatomy 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 5
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones que los contienen y a su uso en el tratamiento de diversas enfermedades, tales como rinitis alérgica. Reivindicacion 1: Un compuesto de formula (1) en la que R1 representa alquilo C1-6 de cadena lineal; a representa 1 o 2; R2 representa -alquilen C1-6-R3-R4, en el que el alquileno es de cadena lineal y está opcionalmente sustituido por un grupo alquilo C1-3, o R2 representa un anillo de 5 a 7 miembros que contiene un grupo SO2; R3 representa -SO2-, -NR5SO2-, -SO2NR6- o -NR7C(O)NR8-; R4 representa -alquilo C1-6, -cicloalquilo C5-7 opcionalmente sustituido por uno o dos grupos alquilo C1-3, -alquilen C1-3-cicloalquilo C5-7 en el que el cicloalquilo C5-7 está opcionalmente sustituido por uno o dos grupos alquilo C1-3, -arilo opcionalmente sustituido por uno o dos grupos halogeno, alquilo C1-3, trifluorometilo, o ciano, o -alquilen C1-3-arilo opcionalmente sustituido por uno o dos grupos halogeno, alquilo C1-3, trifluorometilo, o ciano; R5, R6, R7 y R8 cada uno independientemente representan hidrogeno o alquilo C1-6; o juntos R6 y R4 representan un anillo saturado de 5 a 7 miembros, que opcionalmente contiene un grupo -O-, -S-, -NH-, o -N(CH3)-; o juntos R8 y R4 representan un anillo saturado de 5 a 7 miembros, que opcionalmente contiene un grupo -O-, -S-, -NH-, o -N(CH3)-; o una sal del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95594107P | 2007-08-15 | 2007-08-15 | |
| US8258508P | 2008-07-22 | 2008-07-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR067927A1 true AR067927A1 (es) | 2009-10-28 |
Family
ID=40351220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103529A AR067927A1 (es) | 2007-08-15 | 2008-08-13 | Quinolinas sustituidas, composiciones y combinaciones que las comprenden y el uso de las mismas en la preparacion de un medicamento para tratamiento de enfermedades inflamatorias y/o alergicas del tracto respiratorio. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110281909A1 (es) |
| EP (1) | EP2185542A2 (es) |
| JP (1) | JP2010535845A (es) |
| AR (1) | AR067927A1 (es) |
| CL (1) | CL2008002384A1 (es) |
| PE (1) | PE20090595A1 (es) |
| TW (1) | TW200922581A (es) |
| WO (1) | WO2009021965A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011500634A (ja) * | 2007-10-16 | 2011-01-06 | グラクソ グループ リミテッド | 炎症性疾患およびアレルギー性疾患の治療に用いるキノリン誘導体 |
| WO2012045729A1 (en) | 2010-10-05 | 2012-04-12 | Glaxo Group Limited | Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists |
| WO2012072512A1 (en) | 2010-11-29 | 2012-06-07 | Glaxo Group Limited | N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists |
| JP2014510768A (ja) | 2011-04-11 | 2014-05-01 | グラクソ グループ リミテッド | Ｔｒｐｖ１アンタゴニストとしてのｎ−シクロブチルイミダゾピリジンメチルアミン |
| WO2014022752A1 (en) | 2012-08-03 | 2014-02-06 | Amgen Inc. | Macrocycles as pim inhibitors |
| CN108017603B (zh) | 2013-02-28 | 2021-07-23 | 株式会社蒂奥姆生物 | 三环化合物及其用途 |
| WO2015028976A2 (en) * | 2013-08-30 | 2015-03-05 | Mahesh Kandula | Compounds and methods for the treatment of inflammatory diseases |
| JP6460937B2 (ja) * | 2014-12-04 | 2019-01-30 | 信越化学工業株式会社 | 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法 |
| US9708350B2 (en) | 2014-12-04 | 2017-07-18 | Shin-Etsu Chemical Co., Ltd. | Method for producing polyalkylene glycol derivative having amino group at end, polymerization initiator for use in the same, and alcohol compound as raw material for the polymerization initiator |
| US10377775B2 (en) | 2014-12-04 | 2019-08-13 | Shin-Etsu Chemical Co., Ltd. | Method for producing polyalkylene glycol derivative having amino group at end |
| CA3200753A1 (en) * | 2020-12-11 | 2022-06-16 | Mahesh Kandula | A composition comprising fexofenadine |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| FR2737892B1 (fr) * | 1995-08-17 | 1997-10-24 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique |
| EP1255741A2 (en) | 2000-02-01 | 2002-11-13 | Cor Therapeutics, Inc. | 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa |
| JP4326328B2 (ja) | 2001-07-16 | 2009-09-02 | アストラゼネカ アクチボラグ | キノリン誘導体及びそれらのチロシンキナーゼ阻害薬としての使用 |
| AU2002347336A1 (en) | 2001-12-05 | 2003-06-17 | Astrazeneca Ab | Quinoline derivatives |
| WO2003047584A1 (en) | 2001-12-05 | 2003-06-12 | Astrazeneca Ab | Quinoline derivatives |
| AU2002365665A1 (en) | 2001-12-05 | 2003-06-17 | Astrazeneca Ab | Pharmaceutical compositions comprising benzofuranyl substituted 3-cyanoquinoline derivatives and their use for the treatment of solid tumours |
| WO2003047582A1 (en) | 2001-12-05 | 2003-06-12 | Astrazeneca Ab | Quinoline derivatives as antitumour agents |
| AU2002347360A1 (en) | 2001-12-05 | 2003-06-17 | Astrazeneca Ab | Pharmaceutical compositions comprising benzofuranyl substituted 3-cyanoquinoline derivatives and their use for the treatment of solid tumours |
| WO2003105850A1 (en) | 2002-06-18 | 2003-12-24 | Abbott Laboratories | 2-aminoquinolines as melanin concentrating hormone receptor antagonists |
| GB0215823D0 (en) | 2002-07-09 | 2002-08-14 | Astrazeneca Ab | Quinazoline derivatives |
| US20040033959A1 (en) | 2002-07-19 | 2004-02-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
| TWI347946B (en) * | 2002-10-11 | 2011-09-01 | Otsuka Pharma Co Ltd | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound |
| EP1608639A2 (en) | 2003-02-28 | 2005-12-28 | Bayer Pharmaceuticals Corporation | Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders |
| DE10316081A1 (de) * | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| PL2392565T3 (pl) | 2003-09-26 | 2014-08-29 | Exelixis Inc | Modulatory c-Met i sposoby stosowania |
| FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
| GB0407025D0 (en) | 2004-03-29 | 2004-04-28 | Glaxo Group Ltd | Novel compounds |
| JP5314244B2 (ja) | 2004-10-27 | 2013-10-16 | 富山化学工業株式会社 | 新規な含窒素複素環化合物およびその塩 |
| US20080161305A1 (en) | 2005-04-06 | 2008-07-03 | Exelixis, Inc. | C-Met Modulators and Methods of Use |
| WO2006110516A1 (en) | 2005-04-11 | 2006-10-19 | Abbott Laboratories | Acylhydrazide p2x7 antagonists and uses thereof |
-
2008
- 2008-08-13 EP EP08787173A patent/EP2185542A2/en not_active Withdrawn
- 2008-08-13 US US12/673,027 patent/US20110281909A1/en not_active Abandoned
- 2008-08-13 JP JP2010520568A patent/JP2010535845A/ja active Pending
- 2008-08-13 AR ARP080103529A patent/AR067927A1/es not_active Application Discontinuation
- 2008-08-13 US US12/190,868 patent/US7884114B2/en not_active Expired - Fee Related
- 2008-08-13 WO PCT/EP2008/060622 patent/WO2009021965A2/en not_active Ceased
- 2008-08-13 PE PE2008001370A patent/PE20090595A1/es not_active Application Discontinuation
- 2008-08-13 CL CL2008002384A patent/CL2008002384A1/es unknown
- 2008-08-13 TW TW097130901A patent/TW200922581A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009021965A3 (en) | 2009-04-16 |
| EP2185542A2 (en) | 2010-05-19 |
| JP2010535845A (ja) | 2010-11-25 |
| US7884114B2 (en) | 2011-02-08 |
| CL2008002384A1 (es) | 2009-07-17 |
| US20110281909A1 (en) | 2011-11-17 |
| US20090270355A1 (en) | 2009-10-29 |
| PE20090595A1 (es) | 2009-06-06 |
| WO2009021965A2 (en) | 2009-02-19 |
| TW200922581A (en) | 2009-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |