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AR067354A1 - Compuestos utiles como inhibidores de la raf quinasa - Google Patents

Compuestos utiles como inhibidores de la raf quinasa

Info

Publication number
AR067354A1
AR067354A1 ARP080102801A ARP080102801A AR067354A1 AR 067354 A1 AR067354 A1 AR 067354A1 AR P080102801 A ARP080102801 A AR P080102801A AR P080102801 A ARP080102801 A AR P080102801A AR 067354 A1 AR067354 A1 AR 067354A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
nitrogen
membered
sulfur
oxygen
Prior art date
Application number
ARP080102801A
Other languages
English (en)
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR067354(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of AR067354A1 publication Critical patent/AR067354A1/es

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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

Reivindicacion 1: Un compuesto de formula (1) o una sal aceptable para uso farmacéutico del mismo, donde: Cy1 es un fenilo sustituido en forma opcional o un anillo sustituido en forma opcional de 5-6 miembros, parcialmente insaturado o aromático que presenta 1-3 heteroátomos seleccionados independientemente de nitrogeno, oxígeno o azufre; Cy2 es un anillo saturado de 5-14 miembros sustituido en forma opcional, parcialmente insaturado o aromático monociclico, bicíclico o tricíclico que presenta 0-4 heteroátomos, seleccionados independientemente de nitrogeno, oxígeno o azufre; L1 es un enlace directo o una cadena alquileno C1-6 sustituida en forma opcional, recta o ramificada; L2 es un enlace directo o es una cadena alquileno C1-6 sustituida en forma opcional, recta o ramificada donde 1 o 2 unidades de metileno de L2 están reemplazadas en forma opcional e independiente con -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O- o un cicloalquileno de 3-6 miembros; cada R es independientemente hidrogeno o un grupo alifático C1-6 sustituido en forma opcional; R1 es hidrogeno o un grupo alifático C1-6 sustituido en forma opcional; cada uno de Rx y Ry es seleccionado independientemente de -R2, -halo, -NO2, -CN, -OR2, -SR2, -N(R2)2, -C(O)R2, -CO2R2, -C(O)C(O)R2, -C(O)CH2C(O)R2, -S(O)R2, -S(O)2R2, -C(O)N(R2)2, -SO2N(R2)2, -OC(O)R2, -N(R2)C(O)R2, -N(R2)N(R2)2, -N(R2)-C(=NR2)N(R2)2, -C(=NR2)N(R2)2, -C=NOR2, -N(R2)C(O)N(R2)2, -N(R2)SO2N(R2)2, -N(R2)SO2R2 o -OC(O)N(R2)2; y cada R2 es independientemente hidrogeno o un grupo sustituido en forma opcional seleccionado de un anillo alifático C1-6, arilo monociclico o bicíclico C6-10, o un anillo de 5-10 miembros saturado, parcialmente insaturado o aromático monociclico o bicíclico que presenta 1-4 heteroátomos seleccionados independientemente de nitrogeno, oxígeno o azufre o dos R2 en el mismo nitrogeno se toman junto con el nitrogeno para formar un anillo sustituido en forma opcional de 5-8 miembros saturado, parcialmente insaturado o aromático que presenta 1-4 heteroátomos seleccionados .independientemente de nitrogeno, oxigeno o azufre.
ARP080102801A 2007-06-29 2008-06-27 Compuestos utiles como inhibidores de la raf quinasa AR067354A1 (es)

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