AR064631A1 - Procedimiento para la preparacion de compuestos heterociclicos sustituidos por fluorometilo - Google Patents
Procedimiento para la preparacion de compuestos heterociclicos sustituidos por fluorometiloInfo
- Publication number
- AR064631A1 AR064631A1 ARP070105797A ARP070105797A AR064631A1 AR 064631 A1 AR064631 A1 AR 064631A1 AR P070105797 A ARP070105797 A AR P070105797A AR P070105797 A ARP070105797 A AR P070105797A AR 064631 A1 AR064631 A1 AR 064631A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- preparation
- substituted
- general formula
- compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 238000003682 fluorination reaction Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- -1 fluoromethyl substituted heterocyclic compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedimientos para la preparacion de los compuestos sustituidos de clorometilo (II), Procedimientos para la preparacion de amidas de la formula general (IV), así como compuestos de las formulas generales (1) y (2). Reivindicacion 1: Procedimiento para la preparacion de compuestos heterocíclicos sustituidos por fluorometilo de la formula general (1), en los que R1 representa hidrogeno o fluor; R2 representa un grupo -[A-O]m-R3, en el que A representa alcano C2-C4-diilo, R3 representa alquilo C1-4 y m representa 1 o 2; R4 está seleccionado de entre hidrogeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, alcoxi C1-4-alquilo C1-4, alquil C1-4-tio-alquilo C1-4, haloalcoxi C1-4-alquilo C1-4, alquil C1-6-carbonilo, alcoxi C1-6- carbonilo, fenilo y bencilo, pudiendo los dos radicales mencionados en ultimo término estar, dado el caso, sustituidos por cualquier combinacion de 1, 2 o 3 radicales Ry4 seleccionados independientemente de entre halogeno, ciano, nitro, alquilo C1- 4, haloalquilo C1-4, alcoxi C1-4 y haloalcoxi C1-4 y caracterizado porque se hace reaccionar, en presencia de un agente de fluoracion, un compuesto heterocíclico sustituido por clorometilo de la formula general (2), en la que R1' representa hidrogeno o cloro y R2 y R4 tienen el significado indicado supra.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06126937 | 2006-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064631A1 true AR064631A1 (es) | 2009-04-15 |
Family
ID=38375651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105797A AR064631A1 (es) | 2006-12-21 | 2007-12-20 | Procedimiento para la preparacion de compuestos heterociclicos sustituidos por fluorometilo |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7994207B2 (es) |
| EP (1) | EP2121618A1 (es) |
| JP (1) | JP2010513411A (es) |
| KR (1) | KR20090107506A (es) |
| CN (1) | CN101558044A (es) |
| AR (1) | AR064631A1 (es) |
| AU (1) | AU2007338031B2 (es) |
| BR (1) | BRPI0720410A2 (es) |
| CA (1) | CA2671527A1 (es) |
| EA (1) | EA200900817A1 (es) |
| IL (1) | IL199124A (es) |
| MX (1) | MX2009005863A (es) |
| UA (1) | UA96971C2 (es) |
| WO (1) | WO2008077907A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2086944T3 (pl) * | 2006-11-03 | 2010-06-30 | Basf Se | Sposób wytwarzania difluormetylopirazolilokarboksylanów |
| WO2008145740A1 (de) * | 2007-06-01 | 2008-12-04 | Basf Se | Verfahren zur herstellung n-substituierter (3-dihalomethyl-1-methyl-pyrazol-4-yl)carboxamide |
| BRPI0812958A2 (pt) | 2007-06-15 | 2014-12-09 | Basf Se | Processo para preparar compostos, uso de compostos, e, compostos |
| EP2262756B1 (en) | 2008-02-29 | 2016-08-31 | Basf Se | Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates |
| EP2297111B1 (de) | 2008-05-02 | 2012-06-20 | Basf Se | Verfahren zur herstellung halogensubstituierter 2-(aminomethyliden)-3-oxobuttersäureester |
| WO2009133178A1 (de) | 2008-05-02 | 2009-11-05 | Basf Se | Verfahren zur herstellung von 2-(aminomethyliden)-4,4-difluor-3-oxobuttersäureestern |
| WO2009135808A2 (de) * | 2008-05-05 | 2009-11-12 | Basf Se | Verfahren zur herstellung von 1,3,4-substituierten pyrazolverbindungen |
| DK2285779T3 (da) | 2008-05-08 | 2013-06-24 | Basf Se | Fremgangsmåde til fremstilling af arylcarboxamider |
| EP2307384B1 (en) | 2008-07-21 | 2012-04-25 | Basf Se | Process for preparing 1,3-disubstituted pyrazolecarboxylic esters |
| CN102596911B (zh) | 2009-11-05 | 2015-04-08 | 巴斯夫欧洲公司 | 制备缩醛胺的方法及其在制备1,3-二取代的吡唑化合物中的用途 |
| US8362272B2 (en) | 2009-11-05 | 2013-01-29 | Basf Se | Process for preparing 1,3-disubstituted pyrazole compounds |
| EP2595962B1 (en) * | 2010-07-23 | 2018-07-11 | Solvay Sa | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids |
| EP2632901B1 (en) | 2010-10-27 | 2018-09-12 | Solvay Sa | Process for the preparation of pyrazole-4-carboxamides |
| FR2975992B1 (fr) * | 2011-06-01 | 2013-11-08 | Rhodia Operations | Procede de preparation d'un compose fluoromethylpyrazole sous forme acide carboxylique ou derivee |
| FR2975990B1 (fr) * | 2011-06-01 | 2013-05-24 | Rhodia Operations | Procede de preparation d'un compose organique fluore |
| CN103635461B (zh) * | 2011-06-22 | 2016-01-20 | 中央硝子株式会社 | 吡唑化合物的制造方法 |
| CN102295498A (zh) * | 2011-07-22 | 2011-12-28 | 华东师范大学 | 从苯乙酮连续制备α-氟代苯乙酮的方法 |
| CN102516016A (zh) * | 2011-10-31 | 2012-06-27 | 滨海康杰化学有限公司 | 一溴二氟甲基苯类化合物或三氟甲苯类化合物的制备方法 |
| CN102718712B (zh) * | 2012-06-29 | 2015-04-29 | 江苏威耳化工有限公司 | 3-二氟甲基吡唑-4-羧酸和3-三氟甲基吡唑-4-羧酸的制备方法 |
| CN102731402A (zh) * | 2012-06-29 | 2012-10-17 | 上海康鹏化学有限公司 | 3-三氟甲基吡唑-4-羧酸和3-二氟甲基吡唑-4-羧酸的制备方法 |
| EP3046908B1 (en) * | 2013-09-20 | 2017-08-16 | Bayer CropScience Aktiengesellschaft | Process for preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1h-pyrazole-4-carbaldehyde |
| CN104016920B (zh) * | 2014-06-16 | 2016-08-24 | 联化科技股份有限公司 | 一种含氟甲基吡唑类化合物的联产方法 |
| CN105541716B (zh) | 2015-03-26 | 2024-02-23 | Ａｇｃ株式会社 | 吡唑衍生物的制造方法 |
| CN114195715B (zh) * | 2021-12-31 | 2024-05-10 | 福建永晶科技股份有限公司 | 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4437876A (en) * | 1980-04-14 | 1984-03-20 | Monsanto Company | 2,4-Disubstituted-5-thiazole-carboxylic acids and derivatives |
| US5093347A (en) | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| US5223526A (en) | 1991-12-06 | 1993-06-29 | Monsanto Company | Pyrazole carboxanilide fungicides and use |
| EP0712847A4 (en) * | 1993-08-11 | 1997-05-28 | Nippon Soda Co | IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS A PEST CONTROL |
| KR100344363B1 (ko) | 1993-11-30 | 2002-11-30 | 일라이 릴리 앤드 캄파니 | 2,2-디플루오로케텐실릴아세탈의제조방법 |
| JP3533134B2 (ja) * | 1999-02-15 | 2004-05-31 | 三井化学株式会社 | フッ素化剤及びその製法と使用 |
| DE10215292A1 (de) | 2002-02-19 | 2003-08-28 | Bayer Cropscience Ag | Disubstitutierte Pyrazolylcarbocanilide |
| DE10351088A1 (de) | 2003-10-31 | 2005-06-02 | Bayer Cropscience Gmbh | Verfahren zum Herstellen von fluormethyl-substituierten Heterocyclen |
| EP1761498A1 (de) | 2004-06-18 | 2007-03-14 | Basf Aktiengesellschaft | 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid |
| BRPI0616238B1 (pt) | 2005-09-16 | 2016-01-19 | Syngenta Ltd | processo para a produção de amidas |
| PL2086944T3 (pl) | 2006-11-03 | 2010-06-30 | Basf Se | Sposób wytwarzania difluormetylopirazolilokarboksylanów |
-
2007
- 2007-12-20 UA UAA200907476A patent/UA96971C2/ru unknown
- 2007-12-20 KR KR1020097015204A patent/KR20090107506A/ko not_active Withdrawn
- 2007-12-20 AR ARP070105797A patent/AR064631A1/es unknown
- 2007-12-20 EA EA200900817A patent/EA200900817A1/ru unknown
- 2007-12-20 WO PCT/EP2007/064390 patent/WO2008077907A1/de not_active Ceased
- 2007-12-20 MX MX2009005863A patent/MX2009005863A/es active IP Right Grant
- 2007-12-20 EP EP07858009A patent/EP2121618A1/de not_active Withdrawn
- 2007-12-20 CN CNA2007800464907A patent/CN101558044A/zh active Pending
- 2007-12-20 AU AU2007338031A patent/AU2007338031B2/en not_active Expired - Fee Related
- 2007-12-20 CA CA002671527A patent/CA2671527A1/en not_active Abandoned
- 2007-12-20 JP JP2009542079A patent/JP2010513411A/ja active Pending
- 2007-12-20 US US12/519,032 patent/US7994207B2/en not_active Expired - Fee Related
- 2007-12-20 BR BRPI0720410-8A patent/BRPI0720410A2/pt not_active IP Right Cessation
-
2009
- 2009-06-03 IL IL199124A patent/IL199124A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20100022782A1 (en) | 2010-01-28 |
| MX2009005863A (es) | 2009-06-12 |
| CN101558044A (zh) | 2009-10-14 |
| CA2671527A1 (en) | 2008-07-03 |
| US7994207B2 (en) | 2011-08-09 |
| KR20090107506A (ko) | 2009-10-13 |
| IL199124A (en) | 2013-05-30 |
| JP2010513411A (ja) | 2010-04-30 |
| WO2008077907A1 (de) | 2008-07-03 |
| AU2007338031A1 (en) | 2008-07-03 |
| EP2121618A1 (de) | 2009-11-25 |
| BRPI0720410A2 (pt) | 2013-12-31 |
| UA96971C2 (ru) | 2011-12-26 |
| EA200900817A1 (ru) | 2009-12-30 |
| AU2007338031B2 (en) | 2012-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |