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AR064319A1 - Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otros - Google Patents

Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otros

Info

Publication number
AR064319A1
AR064319A1 ARP070105586A ARP070105586A AR064319A1 AR 064319 A1 AR064319 A1 AR 064319A1 AR P070105586 A ARP070105586 A AR P070105586A AR P070105586 A ARP070105586 A AR P070105586A AR 064319 A1 AR064319 A1 AR 064319A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
occurrence
independently
halo
Prior art date
Application number
ARP070105586A
Other languages
English (en)
Inventor
Charles W Mann
Joseph P Sabatucci
Joel A Goldberg
Richard P Woodworth
Casey C Mccomas
Andrew Fensome
Edward G Melenski
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR064319A1 publication Critical patent/AR064319A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1) o una sal farmacéuticamente aceptable de este; caracterizado porque: m es un entero de 0 a 4; n es un entero de 0 a 2; p es un entero de 0 a 1; q es un entero de 1 a 2; v es un entero de 0 a 2; X es C(R11)2, N(R12), O, o S(O)v; Y es C(R11)2, N(R12), O (2); R1 es arilo sustituido con 0-3 R5 o heteroarilo sustituido con 0-3 R5; R2 es H, alquilo C1-6 recto o ramificado, cicloalquilo C3-6, o arilalquilo C1-6 en donde dicha porcion arilo se sustituye con 0-3 R6; R3 es H, alquilo C1-6 recto o ramificado, alcanol C1-6, cicloalquilo C3-6, o arilalquilo C1-6 en donde dicha porcion arilo se sustituye con 0-3 R7; o R2 y R3, junto con el nitrogeno al cual ellos se adhieren, forman un anillo mono- o bicíclico heterocíclico de 3 a 12 átomos en el anillo, en donde un carbono se puede reemplazar opcionalmente con N, O, S, o SO2, y en donde cualquier átomo de carbono en el anillo se puede sustituir opcionalmente con alquilo C1-4, F, o CF3 o en donde cualquier átomo de N adicional se puede sustituir opcionalmente con alquilo C1-4 con la condicion que si Y es O o N(R12), q no es 2; R4 es H, alquilo C1-6 recto o ramificado, arilo sustituido con 0-3 R8, arilalquilo C1-6 en donde dicha porcion arilo se sustituye con -3 R8, heteroarilo sustituido con 0-3 r8, o heteroarilalquilo C1-6 en donde dicha porcion heteroarilo se sustituye con 0-3 R8; R5 es, independientemente en cada ocurrencia, alquilo C1-6, alcoxi, halo, CF3, OCF3, hidroxi, alcanoiloxi, nitro, nitrilo, alquenilo, alquinilo, arilo sustituido con 0-3 R5 o heteroarilo sustituido con 0-3 R5; R6 es, independientemente en cada ocurrencia, alquilo C1-4, halo o H; R7 es, independientemente en cada ocurrencia, alquilo C1-4, halo o H; R8 es, independientemente en cada ocurrencia, alquilo C1-4, halo o H; R9 es, independientemente en cada ocurrencia, alquilo C1-6, alcoxi, halo, H, CF3, OCF3, hidroxi, alcanoiloxi, nitro, nitrilo, alquenilo, alquinilo, arilo sustituido con 0-3 R10, heteroarilo sustituido con 0-3 R10, alquilsulfoxido, alquilsulfona, alquilsulfonamida, fenilsulfonamida sustituida con 0-3 R10, alquilamido, o arilamido sustituido con -3 R10; o dos R9 adyacentes, junto con los átomos en el anillo a los cuales ellos se adhieren, forman un anillo fusionado de 5 o 6 átomos en el anillo; R10 es, independientemente en cada ocurrencia, H, alquilo C1-6, o halo; R11 es independientemente en cada ocurrencia, H, alquilo C1-6, halo, hidroxi, O- (alquilo C1-6), o arilo sustituido con 0-3 R8; R12 es, independientemente en cada ocurrencia, H, alquilo C1-6, o arilo sustituido con 0-3 R8; R13 es, independientemente en cada ocurrencia, H, alquilo C1-6, haluro, hidroxi, o arilo sustituido con 0-3 R16 o haluro; R15 es, independientemente en cada ocurrencia, H, alquilo C1-4 o haluro; R16 es, independientemente en cada ocurrencia, H, alquilo C1-4, o halo; R17 es, independientemente en cada ocurrencia, H, o alquilo C1.4, en donde el anillo A es fenilo, naftilo, piridilo, pirimidinilo, tienilo, tiazolilo, o pirrolilo.
ARP070105586A 2006-12-12 2007-12-12 Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otros AR064319A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86964206P 2006-12-12 2006-12-12

Publications (1)

Publication Number Publication Date
AR064319A1 true AR064319A1 (es) 2009-03-25

Family

ID=39345330

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105586A AR064319A1 (es) 2006-12-12 2007-12-12 Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otros

Country Status (6)

Country Link
US (1) US20080171737A1 (es)
AR (1) AR064319A1 (es)
CL (1) CL2007003591A1 (es)
PE (1) PE20081577A1 (es)
TW (1) TW200831476A (es)
WO (1) WO2008073956A2 (es)

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WO2005079726A1 (en) 2004-02-23 2005-09-01 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
EP3473289B1 (en) 2004-04-02 2021-09-08 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
CA2655839C (en) 2006-07-14 2015-09-22 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
US10792451B2 (en) 2008-05-12 2020-10-06 Fisher & Paykel Healthcare Limited Patient interface and aspects thereof
US10258757B2 (en) 2008-05-12 2019-04-16 Fisher & Paykel Healthcare Limited Patient interface and aspects thereof
US11660413B2 (en) 2008-07-18 2023-05-30 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
EP3988152B1 (en) 2008-10-10 2024-12-04 Fisher & Paykel Healthcare Limited Nasal pillows for a patient interface
EP3741418B1 (en) 2009-11-18 2024-05-08 Fisher & Paykel Healthcare Limited Nasal interface
EP3406287B1 (en) 2010-10-08 2022-04-27 Fisher & Paykel Healthcare Limited Respiratory mask assembly for breathing assistance apparatus
CN102464627A (zh) * 2010-11-10 2012-05-23 上海药明康德新药开发有限公司 丙烯基-1,3-磺内酰胺的制备方法
WO2012120057A1 (de) * 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120055A1 (de) * 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US10603456B2 (en) 2011-04-15 2020-03-31 Fisher & Paykel Healthcare Limited Interface comprising a nasal sealing portion
GB2529079B (en) 2011-04-15 2016-06-22 Fisher & Paykel Healthcare Ltd An elbow assembly for a mask
EP2855458B1 (en) 2012-05-11 2018-08-08 Reset Therapeutics, Inc. Carbazole-containing sulfonamides as cryptochrome modulators
US10080856B2 (en) 2012-08-08 2018-09-25 Fisher & Paykel Healthcare Limited Headgear for patient interface
EP2892596B1 (en) 2012-09-04 2023-07-26 Fisher&Paykel Healthcare Limited Valsalva mask
EP2897599B1 (en) 2012-09-20 2020-12-30 Temple University - Of The Commonwealth System of Higher Education Substituted alkyl diaryl derivatives, methods of preparation and uses
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
JP7117103B2 (ja) 2014-08-25 2022-08-12 フィッシャー アンド ペイケル ヘルスケア リミテッド 呼吸マスクおよび関連部分、構成要素または部分組立体
CN107922324B (zh) 2015-05-22 2021-02-02 巴斯夫欧洲公司 β-萘酚醚磺酸盐、其制备方法及其作为亮度改进剂的用途
TWI783657B (zh) 2016-07-04 2022-11-11 德商拜耳作物科學公司 苯并磺內醯胺及類似物
USD823455S1 (en) 2017-02-23 2018-07-17 Fisher & Paykel Healthcare Limited Cushion assembly for breathing mask assembly
USD823454S1 (en) 2017-02-23 2018-07-17 Fisher & Paykel Healthcare Limited Cushion assembly for breathing mask assembly
USD824020S1 (en) 2017-02-23 2018-07-24 Fisher & Paykel Healthcare Limited Cushion assembly for breathing mask assembly
CN111559990B (zh) * 2020-05-29 2021-03-09 四川大学华西医院 一种小分子噁噻嗪类衍生物及其应用

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Also Published As

Publication number Publication date
PE20081577A1 (es) 2008-11-28
TW200831476A (en) 2008-08-01
CL2007003591A1 (es) 2008-02-29
WO2008073956A2 (en) 2008-06-19
WO2008073956A3 (en) 2008-07-24
US20080171737A1 (en) 2008-07-17

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