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AR052034A1 - Sal potasica de un inhibidor de la integrasa de vih - Google Patents

Sal potasica de un inhibidor de la integrasa de vih

Info

Publication number
AR052034A1
AR052034A1 ARP050104911A ARP050104911A AR052034A1 AR 052034 A1 AR052034 A1 AR 052034A1 AR P050104911 A ARP050104911 A AR P050104911A AR P050104911 A ARP050104911 A AR P050104911A AR 052034 A1 AR052034 A1 AR 052034A1
Authority
AR
Argentina
Prior art keywords
inhibitor
hiv
integras
compound
potassic salt
Prior art date
Application number
ARP050104911A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36171569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR052034(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc, Angeletti P Ist Richerche Bio filed Critical Merck & Co Inc
Publication of AR052034A1 publication Critical patent/AR052034A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen sales potásicas del Compuesto A y procedimientos para su preparacion, en las que Compuesto A es de la formula (1). El Compuesto A es un inhibidor de la integrasa de VIH de utilidad para el tratamiento o la profilaxis de la infeccion por VIH, para retrasar el inicio del SIDA, y para el tratamiento o la profilaxis del SIDA.
ARP050104911A 2004-12-03 2005-11-24 Sal potasica de un inhibidor de la integrasa de vih AR052034A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63313204P 2004-12-03 2004-12-03

Publications (1)

Publication Number Publication Date
AR052034A1 true AR052034A1 (es) 2007-02-28

Family

ID=36171569

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050104911A AR052034A1 (es) 2004-12-03 2005-11-24 Sal potasica de un inhibidor de la integrasa de vih
ARP140101707A AR101429A2 (es) 2004-12-03 2014-04-24 Sal potásica de un inhibidor de la integrasa de vih

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP140101707A AR101429A2 (es) 2004-12-03 2014-04-24 Sal potásica de un inhibidor de la integrasa de vih

Country Status (35)

Country Link
US (2) US7754731B2 (es)
EP (2) EP1819700B1 (es)
JP (1) JP4705956B2 (es)
KR (2) KR101350420B1 (es)
CN (1) CN101068793B (es)
AR (2) AR052034A1 (es)
AT (2) ATE534645T1 (es)
AU (1) AU2005311671B8 (es)
BR (1) BRPI0518760A8 (es)
CA (1) CA2588398C (es)
CR (1) CR9146A (es)
CY (1) CY1112859T1 (es)
DK (1) DK1819700T3 (es)
EA (1) EA012418B1 (es)
ES (2) ES2370136T3 (es)
GE (1) GEP20105086B (es)
HR (1) HRP20120066T1 (es)
IL (1) IL183614A (es)
MA (1) MA29120B1 (es)
ME (1) ME01985B (es)
MX (1) MX2007006639A (es)
MY (1) MY144320A (es)
NI (1) NI200700138A (es)
NO (1) NO338784B1 (es)
NZ (1) NZ555376A (es)
PE (1) PE20061148A1 (es)
PL (1) PL1819700T3 (es)
PT (1) PT1819700E (es)
RS (1) RS52197B (es)
SI (1) SI1819700T1 (es)
TN (1) TNSN07215A1 (es)
TW (1) TWI344463B (es)
UA (1) UA87884C2 (es)
WO (2) WO2006060712A2 (es)
ZA (1) ZA200704130B (es)

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CN101914067B (zh) * 2010-08-26 2012-07-11 陈岱岭 N-甲基嘧啶酮的合成方法
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WO2012103105A1 (en) 2011-01-24 2012-08-02 Assia Chemical Industries Ltd. Processes for preparing raltegravir and intermediates in the processes
WO2012106534A2 (en) * 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
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CA2833006A1 (en) * 2011-04-22 2012-10-26 Merck Sharp & Dohme Corp. Taste-masked formulations of raltegravir
US9968607B2 (en) 2011-04-25 2018-05-15 Hetero Research Foundation Pharmaceutical compositions of raltegravir, methods of preparation and methods of use therof
EP2522665A1 (en) 2011-05-03 2012-11-14 Sandoz Ag Crystalline sodium salt of an HIV integrase inhibitor
ES2450944T3 (es) 2011-06-01 2014-03-25 Ratiopharm Gmbh Composición y comprimido que comprenden raltegravir
EP2755968A1 (de) 2011-09-16 2014-07-23 Hexal AG Neue polymorphe form von raltegravir-kalium
CN103130787B (zh) * 2011-11-24 2015-06-10 南开大学 嘧啶酮酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
CN103130788B (zh) * 2011-11-24 2015-09-02 南开大学 嘧啶酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
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Also Published As

Publication number Publication date
CN101068793B (zh) 2011-05-25
EP1819683A2 (en) 2007-08-22
TW200631944A (en) 2006-09-16
EA200701204A1 (ru) 2007-12-28
WO2006060712A9 (en) 2006-07-27
MY144320A (en) 2011-08-29
BRPI0518760A2 (pt) 2008-12-09
TNSN07215A1 (en) 2008-11-21
CA2588398C (en) 2011-07-12
HRP20120066T1 (hr) 2012-03-31
JP2008521933A (ja) 2008-06-26
AR101429A2 (es) 2016-12-21
EP1819700A2 (en) 2007-08-22
US20060122205A1 (en) 2006-06-08
IL183614A0 (en) 2007-09-20
NO338784B1 (no) 2016-10-17
PL1819700T3 (pl) 2012-04-30
AU2005311671A1 (en) 2006-06-08
MX2007006639A (es) 2007-06-19
CN101068793A (zh) 2007-11-07
NZ555376A (en) 2009-11-27
ES2370136T3 (es) 2011-12-13
HK1115011A1 (en) 2008-11-14
KR20070089990A (ko) 2007-09-04
ATE534645T1 (de) 2011-12-15
NO20073404L (no) 2007-07-02
EA012418B1 (ru) 2009-10-30
ATE518844T1 (de) 2011-08-15
MA29120B1 (fr) 2007-12-03
IL183614A (en) 2012-03-29
JP4705956B2 (ja) 2011-06-22
EP1819700B1 (en) 2011-11-23
ZA200704130B (en) 2008-08-27
TWI344463B (en) 2011-07-01
RS52197B (sr) 2012-10-31
CY1112859T1 (el) 2016-04-13
WO2006060712A2 (en) 2006-06-08
US20100249410A1 (en) 2010-09-30
NI200700138A (es) 2008-05-13
PT1819700E (pt) 2012-02-01
UA87884C2 (uk) 2009-08-25
PE20061148A1 (es) 2006-11-09
CR9146A (es) 2007-10-04
WO2006060730A3 (en) 2006-08-17
US8357798B2 (en) 2013-01-22
DK1819700T3 (da) 2012-03-19
ES2375788T3 (es) 2012-03-06
ME01985B (me) 2012-10-31
GEP20105086B (en) 2010-10-11
CA2588398A1 (en) 2006-06-08
US7754731B2 (en) 2010-07-13
BRPI0518760A8 (pt) 2017-12-12
SI1819700T1 (sl) 2012-07-31
WO2006060730A2 (en) 2006-06-08
AU2005311671B2 (en) 2011-01-27
EP1819683B1 (en) 2011-08-03
AU2005311671B8 (en) 2011-02-10
KR20130122031A (ko) 2013-11-06
KR101350420B1 (ko) 2014-02-17
WO2006060712A3 (en) 2006-09-21

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