AR051156A1 - Compuestos a base de bicicloheteroarilaminas como ligandos de los canales ionicos,usos de los mismos y composiciones farmaceuticas que los contienen - Google Patents
Compuestos a base de bicicloheteroarilaminas como ligandos de los canales ionicos,usos de los mismos y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR051156A1 AR051156A1 ARP040104919A ARP040104919A AR051156A1 AR 051156 A1 AR051156 A1 AR 051156A1 AR P040104919 A ARP040104919 A AR P040104919A AR P040104919 A ARP040104919 A AR P040104919A AR 051156 A1 AR051156 A1 AR 051156A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- aryl
- heteroalkyl
- Prior art date
Links
- 102000004310 Ion Channels Human genes 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 150000007824 aliphatic compounds Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- -1 azido, carboxy Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 150000003457 sulfones Chemical class 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Hematology (AREA)
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Abstract
Reivindicacion 1:Se reivindica un compuesto a base de aminas que es capaz de modificar los canales ionicos in vivo y que tiene la formula (1) donde: A y B son seleccionados de manera independiente a partir de CH2, CR2'R2', CO, CS y NR2'; Y es seleccionado de manera independiente a partir de CH2, CR2'R2' y NR2'; W y Z son seleccionados de manera independiente a partir de CR4 y N, siempre que W y Z no sean ambos N; R1 es seleccionado a partir de un compuesto alifático sustituido e insustituido, alquilo sustituido o insustituido, heteroalquilo sustituido o insustituido, acilo sustituido o insustituido, arilo sustituido o insustituido, heteroarilo sustituido o insustituido, aralquilo sustituido o insustituido y heteroalquilo sustituido o insustituido; cada R2 y R2' es seleccionado a partir de H, alquilo C1-6 sustituido o insustituido, cicloalquilo C1-6 sustituido o insustituido, arilo sustituido o insustituido y aralquilo sustituido o insustituido; R3 es seleccionado a partir de u anillo sustituido o insustituido de alquilo C1-6, arilo, heteroarilo, heteroalquilo, cicloalquilo, cicloheteroalquilo, bicicloalquenilo, bicicloheteroalquenilo, bicicloarilo y bicicloheteroarilo; R4 es seleccionado a partir de H, alquilo, alquilo sustituido, acilo, acilo sustituido, acilamino sustituido o insustituido, alquilamino sustituido o insustituido, alquiltio sustituido o insustituido, alcoxi sustituido o insustituido, alcoxicarbonilo, alcoxicarbonilo sustituido, alquilarilamino sustituido o insustituido, arilalquiloxi, arilalquiloxi sustituido, amino, arilo, arilo sustituido, arilalquilo, sulfoxido sustituido o insustituido, sulfona sustituida o insustituida, sulfanilo sustituido o insustituido, aminosulfonilo sustituido o insustituido, arilsulfonilo sustituido o insustituido, ácido sulfurico, éster del ácido sulfurico, dihidroxifosforilo sustituido o insustituido, aminodihidrofosforilo sustituido o insustituido, azido, carboxi, carbamoílo sustituido o insustituido, carboxilo, ciano, cicloalquilo sustituido o insustituido, cicloheteroalquilo sustituido o insustituido, dialquilamino sustituido o insustituido, halo, heteroariloxi, heteroarilo sustituido o insustituido, heteroalquilo sustituido o insustituido, hidroxi, nitro y tio; o una sal, solvato o prodroga farmacéuticamente aceptable del mismo; así como sus estereoisomeros y tautomeros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53237103P | 2003-12-24 | 2003-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051156A1 true AR051156A1 (es) | 2006-12-27 |
Family
ID=34748796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104919A AR051156A1 (es) | 2003-12-24 | 2004-12-27 | Compuestos a base de bicicloheteroarilaminas como ligandos de los canales ionicos,usos de los mismos y composiciones farmaceuticas que los contienen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7414131B2 (es) |
| EP (1) | EP1697361A1 (es) |
| JP (1) | JP2007517045A (es) |
| AR (1) | AR051156A1 (es) |
| BR (1) | BRPI0418166A (es) |
| CA (1) | CA2550717A1 (es) |
| TW (1) | TW200530235A (es) |
| WO (1) | WO2005066171A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312330B2 (en) * | 2003-12-24 | 2007-12-25 | Renovis, Inc. | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
| US7402596B2 (en) | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| CN101155787B (zh) * | 2005-04-11 | 2010-11-24 | 弗·哈夫曼-拉罗切有限公司 | (3,4-二氢-喹唑啉-2-基)-茚满-1-基-胺 |
| CN101171238B (zh) * | 2005-05-04 | 2010-12-15 | 弗·哈夫曼-拉罗切有限公司 | 对5-ht受体具有活性的(3,4-二氢-喹唑啉-2-基)-(2-芳氧基-乙基)胺 |
| CN101346375B (zh) * | 2005-11-23 | 2013-04-10 | 阿罗斯药物有限责任公司 | 调节门离子通道用组合物和方法 |
| US20100298285A1 (en) * | 2006-03-16 | 2010-11-25 | Kelly Michael G | Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof |
| TWI464148B (zh) * | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| US20080095720A1 (en) * | 2006-10-18 | 2008-04-24 | Conopco, Inc., D/B/A Unilever | Skin Benefit Compositions with a Vanilloid Receptor Antagonist |
| CA2680275C (en) * | 2007-03-09 | 2016-08-23 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| DK2139334T3 (da) * | 2007-04-17 | 2013-09-23 | Evotec Ag | Kondenserede heterocykliske 2-cyanophenylforbindelser og sammensætninger og anvendelser deraf |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| SI2168966T1 (sl) | 2007-06-15 | 2017-03-31 | Msd K.K. | Derivat biciklo anilina |
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| CA2553969A1 (en) * | 2004-01-23 | 2005-08-04 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
-
2004
- 2004-12-22 TW TW093139996A patent/TW200530235A/zh unknown
- 2004-12-23 US US11/022,324 patent/US7414131B2/en not_active Expired - Fee Related
- 2004-12-23 JP JP2006547416A patent/JP2007517045A/ja not_active Withdrawn
- 2004-12-23 WO PCT/US2004/043456 patent/WO2005066171A1/en not_active Ceased
- 2004-12-23 EP EP04815521A patent/EP1697361A1/en not_active Withdrawn
- 2004-12-23 BR BRPI0418166-2A patent/BRPI0418166A/pt not_active Application Discontinuation
- 2004-12-23 CA CA002550717A patent/CA2550717A1/en not_active Abandoned
- 2004-12-27 AR ARP040104919A patent/AR051156A1/es unknown
Also Published As
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|---|---|
| JP2007517045A (ja) | 2007-06-28 |
| EP1697361A1 (en) | 2006-09-06 |
| BRPI0418166A (pt) | 2007-06-19 |
| CA2550717A1 (en) | 2005-07-21 |
| US20050215572A1 (en) | 2005-09-29 |
| WO2005066171A1 (en) | 2005-07-21 |
| TW200530235A (en) | 2005-09-16 |
| US7414131B2 (en) | 2008-08-19 |
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