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AR059625A1 - Aminoindanos propargilados, procesos para su preparacion, y usos de los mismos - Google Patents

Aminoindanos propargilados, procesos para su preparacion, y usos de los mismos

Info

Publication number
AR059625A1
AR059625A1 ARP070100776A ARP070100776A AR059625A1 AR 059625 A1 AR059625 A1 AR 059625A1 AR P070100776 A ARP070100776 A AR P070100776A AR P070100776 A ARP070100776 A AR P070100776A AR 059625 A1 AR059625 A1 AR 059625A1
Authority
AR
Argentina
Prior art keywords
propargiled
aminoindans
processes
preparation
same
Prior art date
Application number
ARP070100776A
Other languages
English (en)
Inventor
Istvan Miskolczi
Dalia Pinkert
Hugo Gottlieb
Yaacov Herzig
Victor Piryatinsky
David Lerner
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of AR059625A1 publication Critical patent/AR059625A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/48—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos con la estructura: (1) donde R1 es metilo y R2 es H; o R1 es etilo y R2 es hidroximetilo; R3 es H o propargilo; y R4 es ya sea H o 1-butiloxicarbonilo; o un enantiomero o una sal del mismo aceptable para uso farmacéutico. También se provee el uso de una cantidad efectiva para uso terapéutico de dichos compuestos para tratar a un sujeto que sufre un trastorno psiquiátrico, enfermedad de Parkinson. enfermedad de Alzheimer, demencia, o un trastorno neurologico.
ARP070100776A 2006-02-24 2007-02-23 Aminoindanos propargilados, procesos para su preparacion, y usos de los mismos AR059625A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77638606P 2006-02-24 2006-02-24

Publications (1)

Publication Number Publication Date
AR059625A1 true AR059625A1 (es) 2008-04-16

Family

ID=38459533

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070100776A AR059625A1 (es) 2006-02-24 2007-02-23 Aminoindanos propargilados, procesos para su preparacion, y usos de los mismos

Country Status (4)

Country Link
US (2) US7625946B2 (es)
AR (1) AR059625A1 (es)
TW (1) TW200744576A (es)
WO (1) WO2007100583A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008531594A (ja) 2005-02-24 2008-08-14 テバ ファーマシューティカル インダストリーズ リミティド 酒石酸ラドスチジルの製剤
ES2632638T3 (es) * 2005-12-09 2017-09-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Ladostigilo de baja dosis para el tratamiento de la deficiencia cognitiva
US20070135518A1 (en) * 2005-12-09 2007-06-14 Marta Weinstock-Rosin Use of low-dose ladostigil for neuroprotection
TW200744576A (en) 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
WO2007126898A2 (en) * 2006-03-31 2007-11-08 Teva Pharmaceutical Industries, Ltd. Use of ladostigil for the treatment of schizophrenia
CN103339127A (zh) 2010-08-24 2013-10-02 Sgc制药股份有限公司 盐化合物
WO2012059920A1 (en) * 2010-11-02 2012-05-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Ladostigil dosage regime
EP2811995B1 (en) 2012-02-12 2017-08-09 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Ladostigil therapy for immunomodulation
US20220226276A1 (en) * 2019-05-28 2022-07-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions for delivery of ladostigil

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Also Published As

Publication number Publication date
US20070203232A1 (en) 2007-08-30
US7625946B2 (en) 2009-12-01
US8609719B2 (en) 2013-12-17
WO2007100583A3 (en) 2008-11-06
TW200744576A (en) 2007-12-16
US20100093848A1 (en) 2010-04-15
WO2007100583A2 (en) 2007-09-07

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