AR058377A1 - Derivados de pirroliltriazina, procedimientos para su obtencion y formulacion cosmetica y farmaceutica - Google Patents
Derivados de pirroliltriazina, procedimientos para su obtencion y formulacion cosmetica y farmaceuticaInfo
- Publication number
- AR058377A1 AR058377A1 ARP060102308A ARP060102308A AR058377A1 AR 058377 A1 AR058377 A1 AR 058377A1 AR P060102308 A ARP060102308 A AR P060102308A AR P060102308 A ARP060102308 A AR P060102308A AR 058377 A1 AR058377 A1 AR 058377A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- optionally substituted
- hydrogen atom
- branched
- linear
- Prior art date
Links
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 C1-3 alkyl radical Chemical class 0.000 abstract 22
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 150000003254 radicals Chemical class 0.000 abstract 7
- 125000003107 substituted aryl group Chemical group 0.000 abstract 5
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 3
- BDBXZMBHEQTYQT-UHFFFAOYSA-N 4-(1h-pyrrol-2-yl)triazine Chemical class C1=CNC(C=2N=NN=CC=2)=C1 BDBXZMBHEQTYQT-UHFFFAOYSA-N 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 239000006100 radiation absorber Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
La presente se refiere a nuevos derivados de pirroliltriazina de formula general (1), así como a procedimientos de obtencion de los mismos. Las propiedades físico-químicas de dichos compuestos permiten su utilizacion como absorbentes de la radiacion UV. También se refiere a formulaciones cosméticas y farmacéuticas en base al compuesto. Reivindicacion 1: derivado de pirroliltriazina de formula general (1), en donde n = 0, 1, 2, 3 o 4; R1 representa un átomo de hidrogeno; un radical alquilo C1-3 lineal o ramificado opcionalmente sustituido; o un radical fenilo R2', R3' sustituido; R2, R2', R3 y R3' son iguales o diferentes entre sí, representan un átomo de hidrogeno; un radical alquilo opcionalmente sustituido, lineal o ramificado, C1-3 , un radical alcoxi C1-3 ; un radical arilo; halogeno o hidroxi con la condicion de que cuando n = 0, R2 o R3 no sean un derivado acrilo; o bien R2, y R3 están condensados formando con el fenilo un anillo de naftaleno opcionalmente sustituido; R4 y R5 son iguales o diferentes entre sí y representan un átomo de hidrogeno; un radical alquilo C1-4 opcionalmente sustituido, lineal o ramificado; o un radical arilo opcionalmente sustituido; A1 es un radical de formula general (2), (3) o (4); A2 es un radical de la formula general (2) o (5); R6 representa un átomo de hidrogeno; un radical alquilo C1-6 opcionalmente sustituido, lineal o ramificado, saturado o insaturado; o un radical hidroxilo; R7 representa un átomo de hidrogeno; un radical arilo opcionalmente sustituido; un radical heterocíclico opcionalmente sustituido de 5 a 10 átomos, saturado, insaturado o aromático, que puede contener 1, 2 o 3 heteroátomos seleccionados de entre O, N y S; un radical COOR11 un radical -CONR12R13 un radical alcoxi C1-18 opcionalmente sustituido; un radical ariloxi opcionalmente sustituido; un radical -COR14 opcionalmente sustituido; un radical cicloalquilo C3-6, un radical alquilo C1-18, lineal o ramificado, saturado o insaturado, opcionalmente sustituido con por al menos un radical hidroxilo, un grupo SO3M o -N(R15)3+ o bien por un grupo de formula general (6) en el que m = 0 o 1; p = 0, 1, 2, 3, o 4; R16, R17, R19, R19 y R20 son iguales o diferentes entre sí y representan un radical alquilo C1-6 opcionalmente sustituido, un radical alcoxi C1-6 , un radical arilo opcionalmente sustituido o un radical -OSi(R21)3; R21 representa un radical alquilo C1-6, un radical alcoxi C1-6 o un radical arilo opcionalmente sustituido; R11 R12 y R13 son iguales o diferentes entre sí y representan un átomo de hidrogeno; un radical alquilo C1-18 lineal o ramificado opcionalmente sustituido; un radical cicloalquilo C3-6 o bien, R12 y R13 junto con el átomo de nitrogeno forman un heterociclo saturado de 5 a 7 átomos de carbono que puede contener 1, 2 o 3 heteroátomos seleccionados de entre O, N y S; R14 es un radical alquilo opcionalmente sustituido o un radical arilo opcionalmente sustituido; R15 es un radical alquilo opcionalmente sustituido; M es H, Na o K; R6 y R7 o bien R6 y R14 están condensados con el fenilo formando un sistema policíclico, de 9 a 15 átomos, opcionalmente sustituido; R8 y R9 pueden ser iguales o diferentes entre sí y representan un átomo de hidrogeno; un radical acilo C1-18 opcionalmente sustituido; un radical alquilo C1-18, lineal o ramificado, saturado o insaturado, opcionalmente sustituido con al menos un radical hidroxilo, un grupo SO3M, -N(R15)3+ o bien por un grupo de formula general (6), segun se define más. arriba; R10 representa un átomo de hidrogeno o un radical SO3M, siendo M segun se define más arriba.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200501334A ES2272164B1 (es) | 2005-06-03 | 2005-06-03 | Nuevos derivados de pirroliltriazina asi como procedimientos para su obtencion y su utilizacion como agentes protectores contra la radiacionuv. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058377A1 true AR058377A1 (es) | 2008-01-30 |
Family
ID=36688120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102308A AR058377A1 (es) | 2005-06-03 | 2006-06-02 | Derivados de pirroliltriazina, procedimientos para su obtencion y formulacion cosmetica y farmaceutica |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080253978A1 (es) |
| EP (1) | EP1891050A1 (es) |
| JP (1) | JP2008542341A (es) |
| KR (1) | KR20080027286A (es) |
| CN (1) | CN101189227A (es) |
| AR (1) | AR058377A1 (es) |
| AU (1) | AU2006254115A1 (es) |
| BR (1) | BRPI0613545A2 (es) |
| CA (1) | CA2611134A1 (es) |
| ES (1) | ES2272164B1 (es) |
| IL (1) | IL187385A0 (es) |
| MX (1) | MX2007015130A (es) |
| PE (1) | PE20061489A1 (es) |
| RU (1) | RU2007148023A (es) |
| TW (1) | TW200718696A (es) |
| WO (2) | WO2006128791A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2931663B1 (fr) * | 2008-05-30 | 2010-07-30 | Galderma Res & Dev | Nouvelles compositions depigmentantes anhydre comprenant un derive phenolique solubilise. |
| EP2153814A1 (en) | 2008-08-05 | 2010-02-17 | Isdin S.A. | Use of compositions comprising urea |
| EP2153815A1 (en) | 2008-08-05 | 2010-02-17 | Isdin S.A. | Use of urea containing compositions |
| EP2210887A1 (en) * | 2009-01-14 | 2010-07-28 | Isdin, S.A. | Bis resorcinyl triazine derivatives as protecting agents against UV radiation |
| WO2013047411A1 (ja) * | 2011-09-29 | 2013-04-04 | 富士フイルム株式会社 | 新規なトリアジン誘導体、紫外線吸収剤 |
| JP5667955B2 (ja) * | 2011-09-29 | 2015-02-12 | 富士フイルム株式会社 | 新規なトリアジン誘導体、紫外線吸収剤 |
| DE102013215831A1 (de) * | 2013-08-09 | 2015-02-12 | Beiersdorf Ag | Gelförmiges, alkoholisches Sonnenschutzmittel |
| DE102014203011A1 (de) * | 2014-02-19 | 2015-08-20 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an einem oder mehreren Biphenylamin-Derivaten und Verwendung von einem oder mehreren Biphenylamin-Derivaten zur Bräunung der Haut |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0165608B1 (de) * | 1984-06-22 | 1991-01-02 | Ilford Ag | Hydroxyphenyltriazine, Verfahren zu ihrer Herstellung und ihre Verwendung als UV-Absorber |
| DE19543730A1 (de) * | 1995-11-23 | 1997-05-28 | Ciba Geigy Ag | Bis-Resorcinyl-Triazine |
| US6090370A (en) * | 1997-06-27 | 2000-07-18 | Ciba Specialty Chemicals Corporation | Use of selected benzotriazole and triazine derivatives for protecting human hair from the harmful effects of UV radiation |
| JP4088254B2 (ja) | 2002-03-12 | 2008-05-21 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | ヒドロキシフェニルトリアジン化合物を含むｕｖ吸収剤組成物 |
-
2005
- 2005-06-03 ES ES200501334A patent/ES2272164B1/es not_active Expired - Fee Related
-
2006
- 2006-05-17 WO PCT/EP2006/062369 patent/WO2006128791A1/en not_active Ceased
- 2006-06-01 TW TW095119376A patent/TW200718696A/zh unknown
- 2006-06-02 PE PE2006000599A patent/PE20061489A1/es not_active Application Discontinuation
- 2006-06-02 AR ARP060102308A patent/AR058377A1/es unknown
- 2006-06-06 BR BRPI0613545-5A patent/BRPI0613545A2/pt not_active Application Discontinuation
- 2006-06-06 WO PCT/EP2006/062937 patent/WO2006128920A1/en not_active Ceased
- 2006-06-06 RU RU2007148023/04A patent/RU2007148023A/ru not_active Application Discontinuation
- 2006-06-06 JP JP2008514127A patent/JP2008542341A/ja active Pending
- 2006-06-06 MX MX2007015130A patent/MX2007015130A/es unknown
- 2006-06-06 CA CA002611134A patent/CA2611134A1/en not_active Abandoned
- 2006-06-06 US US11/916,450 patent/US20080253978A1/en not_active Abandoned
- 2006-06-06 CN CNA2006800196379A patent/CN101189227A/zh active Pending
- 2006-06-06 AU AU2006254115A patent/AU2006254115A1/en not_active Abandoned
- 2006-06-06 KR KR1020077030889A patent/KR20080027286A/ko not_active Withdrawn
- 2006-06-06 EP EP06763535A patent/EP1891050A1/en not_active Withdrawn
-
2007
- 2007-11-15 IL IL187385A patent/IL187385A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007015130A (es) | 2008-04-10 |
| JP2008542341A (ja) | 2008-11-27 |
| CA2611134A1 (en) | 2006-12-07 |
| WO2006128791A1 (en) | 2006-12-07 |
| WO2006128920A1 (en) | 2006-12-07 |
| RU2007148023A (ru) | 2009-07-20 |
| KR20080027286A (ko) | 2008-03-26 |
| ES2272164B1 (es) | 2008-04-01 |
| CN101189227A (zh) | 2008-05-28 |
| PE20061489A1 (es) | 2007-03-18 |
| AU2006254115A1 (en) | 2006-12-07 |
| TW200718696A (en) | 2007-05-16 |
| US20080253978A1 (en) | 2008-10-16 |
| EP1891050A1 (en) | 2008-02-27 |
| BRPI0613545A2 (pt) | 2009-08-04 |
| IL187385A0 (en) | 2008-02-09 |
| ES2272164A1 (es) | 2007-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |