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AR057867A1 - Inhibidores de pde y combinaciones de los mismos para el tratamiento de trastornos urologicos - Google Patents

Inhibidores de pde y combinaciones de los mismos para el tratamiento de trastornos urologicos

Info

Publication number
AR057867A1
AR057867A1 ARP060104226A ARP060104226A AR057867A1 AR 057867 A1 AR057867 A1 AR 057867A1 AR P060104226 A ARP060104226 A AR P060104226A AR P060104226 A ARP060104226 A AR P060104226A AR 057867 A1 AR057867 A1 AR 057867A1
Authority
AR
Argentina
Prior art keywords
pde
treatment
polypeptide
test compound
bladder
Prior art date
Application number
ARP060104226A
Other languages
English (en)
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37831473&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR057867(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of AR057867A1 publication Critical patent/AR057867A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)

Abstract

Composiciones farmacologicas que comprenden inhibidores de PDE-5 y PDE-4, solos o en combinacion, para el tratamiento de trastornos urologicos que comprenden hiperplasia prostática benigna (HPB), síntomas del tracto urinario inferior (STUI) y en particular síntomas irritativos provocados por obstruccion de la salida de la vejiga (OSV) inducida por HPB. Procedimientos de deteccion selectiva para tales inhibidores de PDE-5 y PDE-4 para uso, solos y en combinacion, en la preparacion de medicamentos para el tratamiento de dichos trastornos urologicos. Reivindicacion 1: Un procedimiento de deteccion selectiva para inhibidores de PDE-5 utiles como agentes terapéuticos en el tratamiento de una enfermedad comprendida en un grupo de enfermedades constituido por hiperplasia prostática benigna (HPB), obstruccion de la salida de la vejiga (OSV) y síntomas del tracto urinario inferior (STUI), que comprende las etapas de i) poner en contacto un compuesto de ensayo con un polipéptido de PDE-5, ii) determinar la actividad del polipéptido de PDE-5 a una cierta concentracion del compuesto de ensayo o en ausencia de dicho compuesto de ensayo, iii) determinar la actividad de dicho polipéptido de PDE-5 a una concentracion diferente de dicho compuesto de ensayo, iv) seleccionar al menos un compuesto con efecto inhibitorio sobre el polipéptido de PDE-5. Reivindicacion 15: Una composicion farmacéutica que contiene al menos un compuesto seleccionado del grupo vardenafilo, sildenafilo, tadalafilo, udenafilo, dasantafilo, avanafilo, SLx2101 y LAS34179 o una sal, un hidrato o un hidrato de una sal de los mismos, para el tratamiento de vejiga neurogénica, vejiga hiperactiva y cistitis intersticial.
ARP060104226A 2005-09-29 2006-09-27 Inhibidores de pde y combinaciones de los mismos para el tratamiento de trastornos urologicos AR057867A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05021261 2005-09-29
EP06007776 2006-04-13

Publications (1)

Publication Number Publication Date
AR057867A1 true AR057867A1 (es) 2007-12-26

Family

ID=37831473

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104226A AR057867A1 (es) 2005-09-29 2006-09-27 Inhibidores de pde y combinaciones de los mismos para el tratamiento de trastornos urologicos

Country Status (23)

Country Link
US (1) US20090186896A1 (es)
EP (1) EP1931797A2 (es)
JP (1) JP2009509984A (es)
KR (1) KR20080056250A (es)
AR (1) AR057867A1 (es)
AU (1) AU2006299232A1 (es)
BR (1) BRPI0616633A2 (es)
CA (1) CA2623657A1 (es)
CR (1) CR9840A (es)
DO (1) DOP2006000207A (es)
EC (1) ECSP088311A (es)
GT (1) GT200600442A (es)
IL (1) IL190201A0 (es)
MA (1) MA29880B1 (es)
NO (1) NO20081973L (es)
PE (1) PE20070587A1 (es)
RU (1) RU2435588C2 (es)
SG (1) SG166106A1 (es)
SV (1) SV2009002851A (es)
TN (1) TNSN08147A1 (es)
TW (1) TW200804603A (es)
UY (1) UY29816A1 (es)
WO (1) WO2007039075A2 (es)

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Also Published As

Publication number Publication date
UY29816A1 (es) 2007-04-30
BRPI0616633A2 (pt) 2011-06-28
NO20081973L (no) 2008-06-20
SV2009002851A (es) 2009-01-14
US20090186896A1 (en) 2009-07-23
PE20070587A1 (es) 2007-08-17
MA29880B1 (fr) 2008-10-03
TNSN08147A1 (en) 2009-07-14
ECSP088311A (es) 2008-06-30
EP1931797A2 (en) 2008-06-18
KR20080056250A (ko) 2008-06-20
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