AR057508A1 - Composicion farmaceutica sinergistica de tramadol y clonixinato de lisina - Google Patents
Composicion farmaceutica sinergistica de tramadol y clonixinato de lisinaInfo
- Publication number
- AR057508A1 AR057508A1 ARP070101074A ARP070101074A AR057508A1 AR 057508 A1 AR057508 A1 AR 057508A1 AR P070101074 A ARP070101074 A AR P070101074A AR P070101074 A ARP070101074 A AR P070101074A AR 057508 A1 AR057508 A1 AR 057508A1
- Authority
- AR
- Argentina
- Prior art keywords
- tramadol
- clonixinate
- analgesia
- drugs
- lisine
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title abstract 2
- 229960004380 tramadol Drugs 0.000 title abstract 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title abstract 2
- 230000002195 synergetic effect Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 230000036592 analgesia Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
- 206010038678 Respiratory depression Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- CVNFYQCHAWFYQI-ZSCHJXSPSA-N clonixin lysine salt Chemical compound NCCCC[C@H](N)C(O)=O.CC1=C(Cl)C=CC=C1NC1=NC=CC=C1C(O)=O CVNFYQCHAWFYQI-ZSCHJXSPSA-N 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 229960003763 lysine clonixinate Drugs 0.000 abstract 1
- 239000000014 opioid analgesic Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composiciones farmacéuticas que contienen dos principios activos siendo uno de ellos un analgésico opiaceo conocido como tramadol o uno de sus enantiomeros o una de sus sales farmacéuticamente aceptables y el otro un analgésico antiinflamatorio no esteroideo conocido como clonixinato de lisina. Cuando se combinan ambos fármacos en proporciones específicas la combinacion produce efectos farmacologicos de analgesia que indican una superaditividad (sinergia), por lo que es posible usar menos cantidad de ambos fármacos para lograr el mismo grado de analgesia que cuando se usan solos. Al disminuir la cantidad de cada fármaco en la combinacion, los efectos colaterales asociados con cada uno de ellos se reducen en numero y grado, por lo tanto esta estrategia terapéutica puede ser una herramienta promisoria en el alivio del dolor agudo moderado a severo con la ventaja de tener menos efectos adversos típicos de opioides tales como predisposicion al abuso, tolerancia, constipacion y depresion respiratoria.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MX2006/000018 WO2007105929A1 (es) | 2006-03-16 | 2006-03-16 | Composición farmacéutica sinergística de tramadol y clonixinato de lisina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057508A1 true AR057508A1 (es) | 2007-12-05 |
Family
ID=38509710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101074A AR057508A1 (es) | 2006-03-16 | 2007-03-16 | Composicion farmaceutica sinergistica de tramadol y clonixinato de lisina |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR057508A1 (es) |
| WO (1) | WO2007105929A1 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661723B2 (en) * | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
-
2006
- 2006-03-16 WO PCT/MX2006/000018 patent/WO2007105929A1/es not_active Ceased
-
2007
- 2007-03-16 AR ARP070101074A patent/AR057508A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007105929A1 (es) | 2007-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2001082914A3 (en) | Topical anesthetic/opioid formulations and uses thereof | |
| WO2007112274A3 (en) | Formulations of low dose non-steroidal anti-inflammatory drugs and beta-cyclodextrin | |
| WO2007143155A3 (en) | Sustained release pharmaceutical dosage form containing phenylephrine | |
| IL194885A0 (en) | Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and an nsaid | |
| DE602007002154D1 (de) | Analgesische Zusammensetzung von topisch angewendeten, nichtsteroiden und entzündungshemmenden Arzneimitteln und Opioiden | |
| AR060836A1 (es) | Un disco trans-mucosa para administrar un agente activo, una composicion trans-mucosa y el metodo de administracion obtenido | |
| AR082167A1 (es) | Formas de dosificacion gastrorretentivas | |
| BRPI0415953B8 (pt) | formulação de dosagem de liberação controlada e conjunto de formas de dosagem de liberação controlada | |
| WO2005035485A3 (en) | Analgesic compounds, their synthesis and pharmaceutical compositions containing them | |
| ECSP099348A (es) | Composición farmacéutica de liberación modificada de un músculo relajante y un aine | |
| UA87841C2 (ru) | Композиция, которая содержит амброксол, для местного применения | |
| BRPI0509245A (pt) | cloridrato [4-(5-aminoetil-2-flúor-fenil)-piperidina-1-il](4-bromo-3 -metil-5-propóxi-tiofeno-2-il)-metanona como um inibidor de triptase de mastócito | |
| AR033390A1 (es) | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes | |
| DE60219963D1 (de) | Pharmazeutische zusammensetzung zur kontrolle des blutzuckers bei patienten mit typ 2 diabetes | |
| WO2006050002A3 (en) | Compositions for controlled delivery of pharmaceutically active compounds | |
| WO2005123192A3 (en) | Improving pain treatment with strontium combinations | |
| AR065917A1 (es) | Composicion farmaceutica en forma de tableta sublingual que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor | |
| AR057508A1 (es) | Composicion farmaceutica sinergistica de tramadol y clonixinato de lisina | |
| DOP2010000265A (es) | Formulacion galenica oral que comprende ketorolaco y vitaminas del complejo b, en la que la vitamina b6 se encuentra em una capa externa separada del resto de principios activos | |
| BR112021016795A8 (pt) | Administração de inibidor de enzima de ativação de sumo e inibidores de checkpoint | |
| MX2009008813A (es) | Composicion farmaceutica que contiene floroglucinol y paracetamol. | |
| CO6331430A2 (es) | Composicion farmaceutica que comprende la combinacion de una sal de ketorolaco y vitaminas del complejo b para el tratamiento de la neuralgia | |
| PE20160038A1 (es) | Composicion farmaceutica sinergistica de dos analgesicos con distinto perfil farmacocinetico | |
| AR060205A1 (es) | Composicion farmaceutica sinergistica de carisoprodol y clonixinato de lisina | |
| AR055807A1 (es) | Composicion farmaceutica sinergistica de diclofenaco y clonixinato de lisina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |