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AR057274A1 - Metodos para el tratamiento y la prevencion de fibrosis - Google Patents

Metodos para el tratamiento y la prevencion de fibrosis

Info

Publication number
AR057274A1
AR057274A1 ARP060101469A ARP060101469A AR057274A1 AR 057274 A1 AR057274 A1 AR 057274A1 AR P060101469 A ARP060101469 A AR P060101469A AR P060101469 A ARP060101469 A AR P060101469A AR 057274 A1 AR057274 A1 AR 057274A1
Authority
AR
Argentina
Prior art keywords
fibrosis
level
treatment
prevention
methods
Prior art date
Application number
ARP060101469A
Other languages
English (en)
Original Assignee
Wyeth Corp
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36741387&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR057274(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp, Harvard College filed Critical Wyeth Corp
Publication of AR057274A1 publication Critical patent/AR057274A1/es

Links

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K33/24—Heavy metals; Compounds thereof
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/20—Interleukins [IL]
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
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  • Hematology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Métodos de seleccion para composiciones utiles para el tratamiento, alivio o prevencion de la fibrosis y/o afeccion asociada con la fibrosis midiendo los cambios en los niveles de IL-21 y/o receptor de IL-21 (IL-21R) (por ejemplo, el nivel de expresion de proteína y/o ARNm de IL-21 y/o IL.21R, el nivel de actividad de IL-21 y/o IL-21R, el nivel de interaccion de IL-21R). La presente proporciona además, antagonistas de IL-21 o IL-21R para el tratamiento de fibrosis y/o afeccion asociada con fibrosis. En este documento se proporcionan también métodos para diagnosticar y monitorear el progreso (por ejemplo, el curso de tratamiento) de fibrosis y/o afeccion asociada co la fibrosis midiendo el nivel de IL-21 y/o IL-21R [es decir, el nivel de actividad de IL-21 y/o IL-21R, el nivel de expresion de IL-21 y/o Il-21R (por ejemplo, el nivel de los productos genéticos de IL-21 y/o Il-21R), y/o el nivel de interaccion de IL-21 con IL-21R].
ARP060101469A 2005-04-14 2006-04-12 Metodos para el tratamiento y la prevencion de fibrosis AR057274A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67137405P 2005-04-14 2005-04-14

Publications (1)

Publication Number Publication Date
AR057274A1 true AR057274A1 (es) 2007-11-28

Family

ID=36741387

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060101469A AR057274A1 (es) 2005-04-14 2006-04-12 Metodos para el tratamiento y la prevencion de fibrosis

Country Status (22)

Country Link
US (2) US7910105B2 (es)
EP (2) EP2436695A1 (es)
JP (1) JP2008538553A (es)
KR (1) KR20080017009A (es)
CN (1) CN101287759A (es)
AR (1) AR057274A1 (es)
AU (1) AU2006236755A1 (es)
BR (1) BRPI0609762A2 (es)
CA (1) CA2604604A1 (es)
CR (1) CR9428A (es)
GT (1) GT200600148A (es)
IL (1) IL186599A0 (es)
MX (1) MX2007012842A (es)
NI (1) NI200700259A (es)
NO (1) NO20075193L (es)
NZ (1) NZ562333A (es)
PE (1) PE20070316A1 (es)
RU (1) RU2419450C2 (es)
SG (1) SG161286A1 (es)
TW (1) TW200716171A (es)
WO (1) WO2006113331A1 (es)
ZA (1) ZA200708756B (es)

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