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AR057213A1 - Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv - Google Patents

Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv

Info

Publication number
AR057213A1
AR057213A1 ARP060105309A ARP060105309A AR057213A1 AR 057213 A1 AR057213 A1 AR 057213A1 AR P060105309 A ARP060105309 A AR P060105309A AR P060105309 A ARP060105309 A AR P060105309A AR 057213 A1 AR057213 A1 AR 057213A1
Authority
AR
Argentina
Prior art keywords
nucleic acids
sequences
tgev
prrsv
prrsv sequences
Prior art date
Application number
ARP060105309A
Other languages
English (en)
Inventor
Sanchez Luis Enjuanes
Lucas Sonia Zuniga
Gurpegui Isabel Sola
Duran Juan Plana
Original Assignee
Consejo Superior Investigacion
Fort Dodge Veterinaria S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Fort Dodge Veterinaria S A filed Critical Consejo Superior Investigacion
Publication of AR057213A1 publication Critical patent/AR057213A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C12N2770/20011—Coronaviridae
    • C12N2770/20041—Use of virus, viral particle or viral elements as a vector
    • C12N2770/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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Abstract

Ácidos nucleicos que comprenden: a) secuencias de un virus de gastroenteritis transmisible (TGEV) competente para la replicacion, donde las secuencias codifican una replicasa de TGEV bajo el control de secuencias reguladoras de la expresion, donde la replicasa se expresa en una célula huésped e iniciará la replicacion del ácido nucleico, por lo que incrementará la cantidad de ácidos nucleicos en la célula; y b) una secuencia que codifica al menos un epitope neutralizador de ORF5 del virus del síndrome reproductivo y respiratorio porcino (PRRSV), donde la secuencia incluye un residuo formador de puentes disulfuro, y c) una secuencia que codifica al menos otro polipéptido capaz de incrementar una respuesta inmune contra el PRRSV. Además, se describen vectores, partículas virales y células huésped que comprenden estos ácidos nucleicos, y también con su uso para la preparacion de vacunas, específicamente para la preparacion de vacunas.
ARP060105309A 2005-12-01 2006-12-01 Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv AR057213A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05026255A EP1792996A1 (en) 2005-12-01 2005-12-01 Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV)

Publications (1)

Publication Number Publication Date
AR057213A1 true AR057213A1 (es) 2007-11-21

Family

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ARP060105309A AR057213A1 (es) 2005-12-01 2006-12-01 Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv

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Country Link
US (2) US20120114683A1 (es)
EP (5) EP1792996A1 (es)
AR (1) AR057213A1 (es)
AT (1) ATE485383T1 (es)
CA (1) CA2631382A1 (es)
CL (1) CL2010000883A1 (es)
DE (1) DE602006017725D1 (es)
DK (1) DK1951882T3 (es)
ES (1) ES2353952T3 (es)
PL (1) PL1951882T3 (es)
PT (1) PT1951882E (es)
TW (2) TWI358455B (es)
WO (1) WO2007062851A2 (es)

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CN107266581B (zh) * 2017-06-13 2021-07-09 四川大学 藏猪il-12重组质粒增强pcv2疫苗免疫佐剂的制备方法及应用
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CN109735551A (zh) * 2018-12-26 2019-05-10 河南农业大学 一种猪繁殖与呼吸综合症病毒重组质粒及其构建方法
CN110055251B (zh) * 2019-04-25 2022-05-27 山东省农业科学院畜牧兽医研究所 一种调控pcv2病毒增殖的序列及其应用
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CN112089804A (zh) * 2020-09-17 2020-12-18 楚雄彝族自治州动物疫病预防控制中心 一种抗猪繁殖与呼吸综合征感染的药物及其检测方法
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CN119258209B (zh) * 2024-12-10 2025-03-28 山东仙普爱瑞科技股份有限公司 一种高表达猪α干扰素和PRRSV GP5蛋白的疫苗、制备方法及其应用
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Publication number Publication date
PL1951882T3 (pl) 2011-05-31
EP1951882A2 (en) 2008-08-06
CL2010000883A1 (es) 2010-12-10
EP2316960A1 (en) 2011-05-04
DK1951882T3 (da) 2011-02-07
WO2007062851A3 (en) 2007-10-11
US20090202588A1 (en) 2009-08-13
US20120114683A1 (en) 2012-05-10
EP2327787A1 (en) 2011-06-01
EP2275565A3 (en) 2011-04-27
CA2631382A1 (en) 2007-06-07
TWI382089B (zh) 2013-01-11
TW200738880A (en) 2007-10-16
ES2353952T3 (es) 2011-03-08
DE602006017725D1 (de) 2010-12-02
EP2275565A2 (en) 2011-01-19
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EP1951882B1 (en) 2010-10-20
ATE485383T1 (de) 2010-11-15
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