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AR057041A1 - Antagonistas de receptor c5a - Google Patents

Antagonistas de receptor c5a

Info

Publication number
AR057041A1
AR057041A1 ARP060102241A ARP060102241A AR057041A1 AR 057041 A1 AR057041 A1 AR 057041A1 AR P060102241 A ARP060102241 A AR P060102241A AR P060102241 A ARP060102241 A AR P060102241A AR 057041 A1 AR057041 A1 AR 057041A1
Authority
AR
Argentina
Prior art keywords
substituted
aryloxy
amino
bialkylamino
acylamino
Prior art date
Application number
ARP060102241A
Other languages
English (en)
Original Assignee
Jerini Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jerini Ag filed Critical Jerini Ag
Publication of AR057041A1 publication Critical patent/AR057041A1/es

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    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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Abstract

La presente se refiere a un compuesto, con preferencia a un antagonista de receptor C5a, que tiene la siguiente estructura (IV): en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 y R22 están seleccionados, de modo individual e independiente, del grupo que comprende H, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, cicloalquilo, cicloalquilo sustituido, heterociclilo, heterociclilo sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, arilalquilo, arilalquilo sustituido, heteroarilalquilo, heteroarilalquilo sustituido, alcoxilo, alcoxilo sustituido, ariloxi, ariloxi sustituido, arilalquiloxi, arilalquiloxi sustituido, aciloxi, aciloxi sustituido, halogeno, hidroxilo, nitro, ciano, acilo, acilo sustituido, mercapto, alquiltio, alquiltio sustituido, amino, amino sustituido, alquilamino, alquilamino sustituido, bialquilamino, bialquilamino sustituido, amino cíclico, amino cíclico sustituido, carbamoílo (.CONH2), carbamoílo sustituido, carboxilo, carbamato, alcoxicarbonilo, alcoxicarbonilo sustituido, acilamino, acilamino sustituido, sulfamoílo (-SO2NH2), sulfamoílo sustituido, haloalquiloxi, - C(O)H, trialquilsililo y azido.
ARP060102241A 2005-05-30 2006-05-30 Antagonistas de receptor c5a AR057041A1 (es)

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