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AR054089A1 - Sintesis de derivados de acido fenoxiacetico - Google Patents

Sintesis de derivados de acido fenoxiacetico

Info

Publication number
AR054089A1
AR054089A1 ARP050104475A ARP050104475A AR054089A1 AR 054089 A1 AR054089 A1 AR 054089A1 AR P050104475 A ARP050104475 A AR P050104475A AR P050104475 A ARP050104475 A AR P050104475A AR 054089 A1 AR054089 A1 AR 054089A1
Authority
AR
Argentina
Prior art keywords
ethyl
general formula
alkyl
compound
propyl
Prior art date
Application number
ARP050104475A
Other languages
English (en)
Inventor
Eric Winter
Carsten Reichel
Dieter Gutheil
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34927119&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR054089(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR054089A1 publication Critical patent/AR054089A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Reivindicacion 1: Método para la preparacion de compuestos de formula general (1), o una sal de los mismos, en la que R1 es alquilo C1-6 ramificado o no ramificado o H; siendo preferiblemente alquilo C1-6 ramificado o no ramificado, entre los cuales se prefieren metilo, etilo, propilo, son más preferidos propilo, etilo y lo más preferido es etilo; X1 o X2 son independientemente uno de otro alquilo C1-6, preferiblemente metilo, etilo, propilo, más preferiblemente metilo, etilo y lo más preferiblemente metilo; que comprende las siguientes etapas: a) hacer reaccionar un compuesto de formula general (2), en la que X1 o X2 son como se definio anteriormente y R2 son independientemente uno de otros alquilo C1-6 ramificado o no ramificado; siendo preferiblemente con alquilo C1-6, metilo, etilo, propilo, más preferiblemente metilo, etilo y lo más preferiblemente metilo; o ambos R2 juntos son un sistema de anillo saturado de 5 o 6 miembros tal como 1,3-dioxanilo o 1,3 dioxolanilo; con un compuesto de formula general: ZCH2CO2R1, en la que Z representa un grupo de sustitucion y R1 es como se definio anteriormente; b) transformar el compuesto de acuerdo con la etapa mencionada, que se representa por la formula general (3), con R1, R2, X1 y X2 como se definio anteriormente en un aldehído de formula general (4), en la que R1, R2, X1 y X2 como se definio anteriormente por: i) transformar el grupo hidroxilo libre de un compuesto de formula general (3) en un grupo saliente; y ii) retirar el grupo saliente generado previamente bajo condiciones reductoras; c) hacer reaccionar el aldehído de formula (4) así obtenido con 1-(4-hidroxi-fenil)-1-hidroxi-2-propilamina, preferiblemente, 4-hidroxi-norefedrina para dar el compuesto de formula general (1); y d) opcionalmente recristalizar el producto así obtenido; y/o e) opcionalmente transformar el producto en una forma de sal farmacologicamente aceptable como el hidrocloruro.
ARP050104475A 2004-10-26 2005-10-26 Sintesis de derivados de acido fenoxiacetico AR054089A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04025432 2004-10-26

Publications (1)

Publication Number Publication Date
AR054089A1 true AR054089A1 (es) 2007-06-06

Family

ID=34927119

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104475A AR054089A1 (es) 2004-10-26 2005-10-26 Sintesis de derivados de acido fenoxiacetico

Country Status (7)

Country Link
US (1) US20090247781A1 (es)
EP (1) EP1809591A1 (es)
JP (1) JP2008517886A (es)
AR (1) AR054089A1 (es)
CA (1) CA2585037A1 (es)
TW (1) TW200630329A (es)
WO (1) WO2006045519A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY126489A (en) 1998-07-08 2006-10-31 Kissei Pharmaceutical Phenoxyacetic acid derivatives and medicinal compositions containing the same
JP4132020B2 (ja) * 2001-03-12 2008-08-13 キッセイ薬品工業株式会社 フェノキシ酢酸誘導体の製造中間体およびその使用方法
PL206246B1 (pl) 2001-09-13 2010-07-30 Kissei Pharmaceutical Co Ltdkissei Pharmaceutical Co Ltd Pochodna hydroksynorefedryny, jej kryształy, kompozycja farmaceutyczna, lek oraz zastosowanie
UA79498C2 (en) * 2002-09-05 2007-06-25 Kissei Pharmaceutical Intermediates for preparation of phenoxy-acetic derivates and processes of their preparation
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine

Also Published As

Publication number Publication date
WO2006045519A1 (en) 2006-05-04
TW200630329A (en) 2006-09-01
US20090247781A1 (en) 2009-10-01
CA2585037A1 (en) 2006-05-04
EP1809591A1 (en) 2007-07-25
JP2008517886A (ja) 2008-05-29

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